The DOI matches its Crossref record.
Targeting of Cancer Cells Using Click-Functionalized Polymer Capsules
Open accessAbstract
Targeted delivery of drugs to specific cells allows a high therapeutic dose to be delivered to the target site with minimal harmful side effects. Combining targeting molecules with nanoengineered drug carriers, such as polymer capsules, micelles and polymersomes, has significant potential to improve the therapeutic delivery and index of a range of drugs. We present a general approach for functionalization of low-fouling, nanoengineered polymer capsules with antibodies using click chemistry. We demonstrate that antibody (Ab)-functionalized capsules specifically bind to colorectal cancer cells even when the target cells constitute less than 0.1% of the total cell population. This precise targeting offers promise for drug delivery applications.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cited by
Minimum information reporting in bio–nano experimental literature
Faria, M., Björnmalm, M., Thurecht, K. J., Kent, S. J., Parton, R. G., Kavallaris, M., Johnston, A. P. R., Gooding, J. J., Corrie, S. R., Boyd, B. J., et al. (2018) · Nature Nanotechnology · doi:10.1038/s41565-018-0246-4 · Cited by 710
Self-citationLayer-by-Layer Nanoparticles with a pH-Sheddable Layer for in Vivo Targeting of Tumor Hypoxia
Poon, Z., Chang, D., Zhao, X., & Hammond, P. T. (2011) · ACS Nano · doi:10.1021/nn200876f · Cited by 343
Cui, J., Yan, Y., Such, G. K., Liang, K., Ochs, C. J., Postma, A., & Caruso, F. (2012) · Biomacromolecules · doi:10.1021/bm300835r · Cited by 317
Self-citationThe Future of Layer-by-Layer Assembly: A Tribute to ACS Nano Associate Editor Helmuth Möhwald
Zhao, S., Caruso, F., Dähne, L., Decher, G., De Geest, B. G., Fan, J., Feliu, N., Gogotsi, Y., Hammond, P. T., Hersam, M. C., et al. (2019) · ACS Nano · doi:10.1021/acsnano.9b03326 · Cited by 283
Self-citationAbd Ellah, N. H., & Abouelmagd, S. A. (2017) · Expert Opinion on Drug Delivery · doi:10.1080/17425247.2016.1213238 · Cited by 164
Metadata
- Authors
- Kamphuis, M. M. J., Johnston, A. P. R., Such, G. K., Dam, H. H., Evans, R. A., Scott, A. M., Nice, E. C., Heath, J. K., & Caruso, F.
- Venue
- Journal of the American Chemical Society
- Publisher
- American Chemical Society (ACS)
- Published
- 2010-10-26
- Volume
- 132
- Issue
- 45
- Pages
- 15881-15883
- ISSN
- 0002-7863 (ISSN-L)
- 1520-5126
- OpenAlex
- W2044958723
- Cited by
- 166
- References
- 0
- FWCI
- 10.01
- Type
- journal article
- Language
- en
- Open access
- hybrid
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Targeting of Cancer Cells Using Click-Functionalized Polymer Capsules. https://app.cochat.ai/papers/10.1021/ja106405c
- The paper
- Kamphuis, M. M. J., Johnston, A. P. R., Such, G. K., Dam, H. H., Evans, R. A., Scott, A. M., Nice, E. C., Heath, J. K., & Caruso, F. (2010). Targeting of Cancer Cells Using Click-Functionalized Polymer Capsules. Journal of the American Chemical Society. https://doi.org/10.1021/ja106405c
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
