The DOI matches its Crossref record; 33 of the 33 references it cites were found in a registry or an index.
Immobilization and Intracellular Delivery of an Anticancer Drug Using Mussel-Inspired Polydopamine Capsules
Open accessAbstract
We report a facile approach to immobilize pH-cleavable polymer-drug conjugates in mussel-inspired polydopamine (PDA) capsules for intracellular drug delivery. Our design takes advantage of the facile PDA coating to form capsules, the chemical reactivity of PDA films, and the acid-labile groups in polymer side chains for sustained pH-induced drug release. The anticancer drug doxorubicin (Dox) was conjugated to thiolated poly(methacrylic acid) (PMA(SH)) with a pH-cleavable hydrazone bond, and then immobilized in PDA capsules via robust thiol-catechol reactions between the polymer-drug conjugate and capsule walls. The loaded Dox showed limited release at physiological pH but significant release (over 85%) at endosomal/lysosomal pH. Cell viability assays showed that Dox-loaded PDA capsules enhanced the efficacy of eradicating HeLa cancer cells compared with free drug under the same assay conditions. The reported method provides a new platform for the application of stimuli-responsive PDA capsules as drug delivery systems.
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Citations
Cites
Mussel-inspired surface chemistry for multifunctional coatings
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Sensors and regulators of intracellular pH
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Facile Conjugation of Biomolecules onto Surfaces via Mussel Adhesive Protein Inspired Coatings
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The physical and chemical properties of eumelanin
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Self-citationDopamine-Induced Reduction and Functionalization of Graphene Oxide Nanosheets
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Cited by
Liu, Y., Ai, K., & Lu, L. (2014) · Chemical Reviews · doi:10.1021/cr400407a · Cited by 4,794
Polydopamine Surface Chemistry: A Decade of Discovery
Ryu, J. H., Messersmith, P. B., & Lee, H. (2018) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.7b19865 · Cited by 1,843
The chemistry behind catechol-based adhesion
Saiz‐Poseu, J., Mancebo‐Aracil, J., Nador, F., Busqué, F., & Ruiz‐Molina, D. (2019) · Angewandte Chemie International Edition · doi:10.1002/anie.201801063 · Cited by 850
Polydopamine and Eumelanin: From Structure–Property Relationships to a Unified Tailoring Strategy
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Recent approaches in designing bioadhesive materials inspired by mussel adhesive protein
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Metadata
- Authors
- Cui, J., Yan, Y., Such, G. K., Liang, K., Ochs, C. J., Postma, A., & Caruso, F.
- Venue
- Biomacromolecules
- Publisher
- American Chemical Society (ACS)
- Published
- 2012-07-13
- Volume
- 13
- Issue
- 8
- Pages
- 2225-2228
- ISSN
- 1525-7797 (ISSN-L)
- 1526-4602
- OpenAlex
- W2010750052
- Cited by
- 317
- References
- 33
- FWCI
- 10.46
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- The paper
- Cui, J., Yan, Y., Such, G. K., Liang, K., Ochs, C. J., Postma, A., & Caruso, F. (2012). Immobilization and Intracellular Delivery of an Anticancer Drug Using Mussel-Inspired Polydopamine Capsules. Biomacromolecules. https://doi.org/10.1021/bm300835r
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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