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Enantioselective α-Benzylation of Aldehydes via Photoredox Organocatalysis
Open accessAbstract
The first enantioselective aldehyde α-benzylation using electron-deficient aryl and heteroaryl substrates has been accomplished. The productive merger of a chiral imidazolidinone organocatalyst and a commercially available iridium photoredox catalyst in the presence of household fluorescent light directly affords the desired homobenzylic stereogenicity in good to excellent yield and enantioselectivity. The utility of this methodology has been demonstrated via rapid access to an enantioenriched drug target for angiogenesis suppression.
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Asymmetric catalysis activated by visible light
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Bergonzini, G., Schindler, C. S., Wallentin, C.-J., Jacobsen, E. N., & Stephenson, C. R. J. (2014) · Chem. Sci. · doi:10.1039/c3sc52265b · Cited by 277
Metadata
- Authors
- Shih, H.-W., Vander Wal, M. N., Grange, R. L., & MacMillan, D. W. C.
- Venue
- Journal of the American Chemical Society
- Publisher
- American Chemical Society (ACS)
- Published
- 2010-09-10
- Volume
- 132
- Issue
- 39
- Pages
- 13600-13603
- ISSN
- 0002-7863 (ISSN-L)
- 1520-5126
- OpenAlex
- W1996259344
- Cited by
- 509
- References
- 0
- FWCI
- 27.31
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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