The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Core-Clickable PEG-Branch-Azide Bivalent-Bottle-Brush Polymers by ROMP: Grafting-Through and Clicking-To
Open accessAbstract
The combination of highly efficient polymerizations with modular "click" coupling reactions has enabled the synthesis of a wide variety of novel nanoscopic structures. Here we demonstrate the facile synthesis of a new class of clickable, branched nanostructures, polyethylene glycol (PEG)-branch-azide bivalent-brush polymers, facilitated by "graft-through" ring-opening metathesis polymerization of a branched norbornene-PEG-chloride macromonomer followed by halide-azide exchange. The resulting bivalent-brush polymers possess azide groups at the core near a polynorbornene backbone with PEG chains extended into solution; the structure resembles a unimolecular micelle. We demonstrate copper-catalyzed azide-alkyne cycloaddition (CuAAC) "click-to" coupling of a photocleavable doxorubicin (DOX)-alkyne derivative to the azide core. The CuAAC coupling was quantitative across a wide range of nanoscopic sizes (∼6-∼50 nm); UV photolysis of the resulting DOX-loaded materials yielded free DOX that was therapeutically effective against human cancer cells.
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Cites
Nanocarriers as an emerging platform for cancer therapy
Peer, D., Karp, J. M., Hong, S., Farokhzad, O. C., Margalit, R., & Langer, R. (2007) · Nature Nanotechnology · doi:10.1038/nnano.2007.387 · Cited by 8,710
Tornøe, C. W., Christensen, C., & Meldal, M. (2002) · The Journal of Organic Chemistry · doi:10.1021/jo011148j · Cited by 8,696
The convergence of synthetic organic and polymer chemistries
Hawker, C. J., & Wooley, K. L. (2005) · Science · doi:10.1126/science.1109778 · Cited by 1,298
Dieterich, D. C., Link, A. J., Graumann, J., Tirrell, D. A., & Schuman, E. M. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0601637103 · Cited by 874
Self-citationMarrying click chemistry with polymerization: expanding the scope of polymeric materials
Golas, P. L., & Matyjaszewski, K. (2010) · Chem. Soc. Rev. · doi:10.1039/b901978m · Cited by 863
Cited by
Design of polymeric nanoparticles for biomedical delivery applications
Elsabahy, M., & Wooley, K. L. (2012) · Chemical Society Reviews · doi:10.1039/c2cs15327k · Cited by 1,717
Polymeric nanostructured materials for biomedical applications
Tang, Z., He, C., Tian, H., Ding, J., Hsiao, B. S., Chu, B., & Chen, X. (2016) · Progress in Polymer Science · doi:10.1016/j.progpolymsci.2016.05.005 · Cited by 363
Shieh, P., Nguyen, H. V.-T., & Johnson, J. A. (2019) · Nature Chemistry · doi:10.1038/s41557-019-0352-4 · Cited by 233
Self-citationCationic salt-responsive bottle-brush polymers
Yao, K., Chen, Y., Zhang, J., Bunyard, C., & Tang, C. (2013) · Macromolecular Rapid Communications · doi:10.1002/marc.201300088 · Cited by 41
Controlled-Release System of Small Molecules Triggered by the Photothermal Effect of Polypyrrole
Zhang, H., Xiong, L., Liao, X., & Huang, K. (2016) · Macromolecular Rapid Communications · doi:10.1002/marc.201500523 · Cited by 25
Metadata
- Authors
- Johnson, J. A., Lu, Y. Y., Burts, A. O., Lim, Y.-H., Finn, M. G., Koberstein, J. T., Turro, N. J., Tirrell, D. A., & Grubbs, R. H.
- Venue
- Journal of the American Chemical Society
- Publisher
- American Chemical Society (ACS)
- Published
- 2010-12-13
- Volume
- 133
- Issue
- 3
- Pages
- 559-566
- ISSN
- 0002-7863 (ISSN-L)
- 1520-5126
- OpenAlex
- W1982488307
- Cited by
- 353
- References
- 5
- FWCI
- 11.52
- Type
- journal article
- Language
- en
- Open access
- green
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