The DOI matches its Crossref record; 40 of the 40 references it cites were found in a registry or an index.
Instantaneous and Quantitative Functionalization of Gold Nanoparticles with Thiolated DNA Using a pH-Assisted and Surfactant-Free Route
Abstract
The attachment of thiolated DNA to gold nanoparticles (AuNPs) has enabled many landmark works in nanobiotechnology. This conjugate chemistry is typically performed using a salt-aging protocol where, in the presence of an excess amount of DNA, NaCl is gradually added to increase DNA loading over 1-2 days. To functionalize large AuNPs, surfactants need to be used, which may generate difficulties for downstream biological applications. We report herein a novel method using a pH 3.0 citrate buffer to complete the attachment process in a few minutes. More importantly, it allows for quantitative DNA adsorption, eliminating the need to quantify the number of adsorbed DNA and allowing the adsorption of multiple DNAs with different sequences at predetermined ratios. The method has been tested for various DNAs over a wide range of AuNP sizes. Our work suggests a synergistic effect between pH and salt in DNA attachment and reveals the fundamental kinetics of AuNP aggregation versus DNA adsorption, providing a novel means to modulate the interactions between DNA and AuNPs.
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Cites
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Self-citationStructure-Based Carbon Nanotube Sorting by Sequence-Dependent DNA Assembly
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Cited by
Surface Functionalization of Gold Nanoparticles with Red Blood Cell Membranes
Gao, W., Hu, C. J., Fang, R. H., Luk, B. T., Su, J., & Zhang, L. (2013) · Advanced Materials · doi:10.1002/adma.201300638 · Cited by 465
Lee, B., Lee, K., Panda, S., Gonzales-Rojas, R., Chong, A., Bugay, V., Park, H. M., Brenner, R., Murthy, N., & Lee, H. Y. (2018) · Nature Biomedical Engineering · doi:10.1038/s41551-018-0252-8 · Cited by 361
Hybrid nanoparticles for combination therapy of cancer
He, C., Lu, J., & Lin, W. (2015) · Journal of Controlled Release · doi:10.1016/j.jconrel.2015.09.029 · Cited by 174
Meng, Y., Liu, P., Zhou, W., Ding, J., & Liu, J. (2018) · ACS Nano · doi:10.1021/acsnano.8b03019 · Cited by 149
Self-citationEl Hallal, R., Lyu, N., & Wang, Y. (2021) · Molecules · doi:10.3390/molecules26030567 · Cited by 51
Metadata
- Authors
- Zhang, X., Servos, M. R., & Liu, J.
- Venue
- Journal of the American Chemical Society
- Publisher
- American Chemical Society (ACS)
- Published
- 2012-04-22
- Volume
- 134
- Issue
- 17
- Pages
- 7266-7269
- ISSN
- 0002-7863 (ISSN-L)
- 1520-5126
- OpenAlex
- W2330939239
- Cited by
- 593
- References
- 40
- FWCI
- 14.45
- Type
- journal article
- Language
- en
- Open access
- closed
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- Zhang, X., Servos, M. R., & Liu, J. (2012). Instantaneous and Quantitative Functionalization of Gold Nanoparticles with Thiolated DNA Using a pH-Assisted and Surfactant-Free Route. Journal of the American Chemical Society. https://doi.org/10.1021/ja3014055
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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