Rational Design of Proteolytically Stable, Cell-Permeable Peptide-Based Selective Mcl-1 Inhibitors

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Structural insights into the degradation of Mcl-1 induced by BH3 domains

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The MCL-1 BH3 helix is an exclusive MCL-1 inhibitor and apoptosis sensitizer

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A Stapled BID BH3 Helix Directly Binds and Activates BAX

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Improving Oral Bioavailability of Peptides by Multiple N‐Methylation: Somatostatin Analogues

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Acquired resistance to ABT-737 in lymphoma cells that up-regulate MCL-1 and BFL-1

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The Challenge of Drugging Undruggable Targets in Cancer: Lessons Learned from Targeting BCL-2 Family Members

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Mimicking the BH3 domain to kill cancer cells

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Structure of the Stapled p53 Peptide Bound to Mdm2

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Development of a Potent Bcl-x L Antagonist Based on α-Helix Mimicry

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‘Seed’ analysis of off-target siRNAs reveals an essential role of Mcl-1 in resistance to the small-molecule Bcl-2/Bcl-XL inhibitor ABT-737

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Terphenyl-Based Bak BH3 α-Helical Proteomimetics as Low-Molecular-Weight Antagonists of Bcl-x L

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In Silico Prediction of Membrane Permeability from Calculated Molecular Parameters

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Enhanced Metabolic Stability and Protein‐Binding Properties of Artificial α Helices Derived from a Hydrogen‐Bond Surrogate: Application to Bcl‐xL

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Sequence‐Based Design of α/β‐Peptide Foldamers That Mimic BH3 Domains

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Bcl-2 Family Proteins: Strategies for Overcoming Chemoresistance in Cancer

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Chapter 22 Synthesis and Biophysical Characterization of Stabilized α‐Helices of BCL‐2 Domains

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Achieving cell penetration with distance-matching cysteine cross-linkers: a facile route to cell-permeable peptide dual inhibitors of Mdm2/Mdmx

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Facile synthesis of stapled, structurally reinforced peptide helices via a photoinduced intramolecular 1,3-dipolar cycloaddition reaction

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Identification of Expression Signatures Predictive of Sensitivity to the Bcl-2 Family Member Inhibitor ABT-263 in Small Cell Lung Carcinoma and Leukemia/Lymphoma Cell Lines

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The effect of N‐methylation on helical peptides

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The effect of N-methylation on helical peptides.

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Therapeutic Peptides: Current Applications and Future Directions

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From basic apoptosis discoveries to advanced selective BCL-2 family inhibitors

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Inhibition of α-helix-mediated protein–protein interactions using designed molecules

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Modulators of Protein–Protein Interactions

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Potent and selective small-molecule MCL-1 inhibitors demonstrate on-target cancer cell killing activity as single agents and in combination with ABT-263 (navitoclax)

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Oncogenic protein interfaces: small molecules, big challenges

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Inhibition of Mcl-1 through covalent modification of a noncatalytic lysine side chain

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Design of potent and proteolytically stable oxyntomodulin analogs

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ИСПОЛЬЗОВAНИЕ ПОТЕНЦИAЛA СОЦИAЛЬНЫХ ПAРТНЕРОВ В ПОДГОТОВКЕ БУДУЩИХ ПЕДAГОГОВ

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Biophysical studies and anti‐growth activities of a peptide, a certain analog and a fragment peptide derived from α‐fetoprotein

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Some Attempts in the Rational Design of Heterogeneous Catalysts Using Density Functional Theory Calculations

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Semi-rational approaches to engineering enzyme activity: combining the benefits of directed evolution and rational design

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The length of the N-terminal region of a photocleavable peptide bound to DR1 determines the kinetics of photocleavable peptide fragment release

Negroni, M. P., & Stern, L. J. (2016) · The Journal of Immunology · doi:10.4049/jimmunol.196.supp.185.1