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Bridged Analogues for p53-Dependent Cancer Therapy Obtained by S-Alkylation

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Peptide Macrocycles Developed from Precisely Regulated Multiple Cyclization of Unprotected Peptides

Wang, J., Zha, M., Fei, Q., Liu, W., Zhao, Y., & Wu, C. (2017) · Chemistry - A European Journal · doi:10.1002/chem.201703139 · Cited by 9 · see citing works

An enhanced functional interrogation/manipulation of intracellular signaling pathways with the peptide ‘stapling’ technology

He, Y., Chen, D. X. W., & Zheng, W. (2015) · Oncogene · doi:10.1038/onc.2015.37 · Cited by 9 · see citing works

Exploring the Effect of Hydrocarbon Cross‐Linkers on the Structure and Binding of Stapled p53 Peptides

Choudhury, A. R., Gaikwad, V., Maity, A., & Chakrabarti, R. (2025) · Proteins Structure Function and Bioinformatics · doi:10.1002/prot.26793 · Cited by 8 · see citing works

Tightening up the structure, lighting up the pathway: application of molecular constraints and light to manipulate protein folding, self-assembly and function

Markiewicz, B. N., Culik, R. M., & Gai, F. (2014) · Science China Chemistry · doi:10.1007/s11426-014-5225-5 · Cited by 8 · see citing works

Folding-Assisted Peptide Disulfide Formation and Dimerization

Victorio, C. G., & Sawyer, N. (2023) · ACS Chemical Biology · doi:10.1021/acschembio.3c00268 · Cited by 7 · see citing works

Design of stapled oxyntomodulin analogs containing functionalized biphenyl cross-linkers

Tian, Y., Zou, H., An, P., Zhou, Z., Shen, W., & Lin, Q. (2018) · Tetrahedron · doi:10.1016/j.tet.2018.11.060 · Cited by 7 · see citing works

Multicomponent Peptide Stapling as a Diversity‐Driven Tool for the Development of Inhibitors of Protein–Protein Interactions

Ricardo, M. G., Ali, A. M., Plewka, J., Surmiak, E., Łabuzek, B., Neochoritis, C. G., Atmaj, J., Skalniak, Ł., Zhang, R., Holak, T. A., et al. (2020) · Angewandte Chemie · doi:10.1002/ange.201916257 · Cited by 7 · see citing works

The 1,3‐diyne linker as a rigid “ i , i +7” staple for α‐helix stabilization: Stereochemistry at work

Verlinden, S., Geudens, N., holsbeeck, K. V., Mannes, M., Martins, J. C., Verniest, G., & Ballet, S. (2019) · Journal of Peptide Science · doi:10.1002/psc.3194 · Cited by 5 · see citing works

Receptor-templated stapling of intrinsically disordered peptide ligands

Haney, C. M., & Horne, W. S. (2015) · Organic & Biomolecular Chemistry · doi:10.1039/c5ob00269a · Cited by 5 · see citing works

Design and Synthetic Strategies for Helical Peptides

Tu, L., Wang, D., & Li, Z. (2019) · Methods in molecular biology · doi:10.1007/978-1-4939-9504-2_7 · Cited by 5 · see citing works

Stabilizing a Native Fold of Alpha-Synuclein with Short Helix-Constrained Peptides

Meade, R. M., Allen, S. G., Lopez, A. J., Williams, C., Thomas-Wright, I., Heon‐Roberts, R., Carey-Wood, M., Tang, T. M. S., Sero, J., Hunt, V. L., et al. (2025) · JACS Au · doi:10.1021/jacsau.5c00694 · Cited by 4 · see citing works

A study of 2-component i, i + 3 peptide stapling using thioethers

Louis, L. E. S., Rodriguez, T. M., & Waters, M. L. (2017) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2017.10.037 · Cited by 4 · see citing works

Design, synthesis and antitumor activity of Ascaphin-8 derived stapled peptides based on halogen–sulfhydryl click chemical reactions

Kong, X., Zhang, N., Shen, H., Wang, N., Cong, W., Liu, C., & Hu, H. (2023) · RSC Advances · doi:10.1039/d3ra02743k · Cited by 4 · see citing works

Interchain doubly-bridged α-helical peptides for the development of protein binders

Chen, Y., Liang, J., Li, T., Lin, P. J., Zhao, Y., & Wu, C. (2019) · Chinese Chemical Letters · doi:10.1016/j.cclet.2019.02.013 · Cited by 3 · see citing works

Constructing Thioether/Vinyl Sulfide-tethered Helical Peptides Via Photo-induced Thiol-ene/yne Hydrothiolation

Shi, X., Liu, Y., Zhao, R., & Li, Z. (2018) · Journal of Visualized Experiments · doi:10.3791/57356 · Cited by 3 · see citing works

Drug Design Methods to Regulate Protein–Protein Interactions

Poluri, K. M., Gulati, K., Tripathi, D. K., & Nagar, N. (2023) · Springer eBooks · doi:10.1007/978-981-99-2423-3_6 · Cited by 2 · see citing works

Bis‐Lactam Peptide [i, i + 4]‐Stapling

Hu, X., Wu, B., & Zheng, W. (2019) · Chinese Journal of Chemistry · doi:10.1002/cjoc.201800446 · Cited by 2 · see citing works

Facile Chemoselective Modification of Thioethers Generates Chiral Center-Induced Helical Peptides

Liu, Y., Hu, K., Yin, F., & Li, Z. (2021) · Methods in molecular biology · doi:10.1007/978-1-0716-1617-8_23 · Cited by 2 · see citing works

Peptidomimetics of α‐Helical and β‐Strand Protein Binding Epitopes

Bionda, N., & Fasan, R. (2015) · Wiley eBooks · doi:10.1002/9781118771723.ch15 · Cited by 2 · see citing works

Tetrazine cyclized peptides for one-bead-one-compound library: Synthesis and sequencing

Das, S., & Nag, A. (2024) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/bs.mie.2024.04.015 · Cited by 1 · see citing works

Ras-Targeting Stabilized Peptide Increases Radiation Sensitivity of Cancer Cells

Qin, W., Wei, X., Yang, D., Luo, Q., Huang, M., Xing, S., Wei, W., Liang, L., Huang, J. L., Zhou, Z., et al. (2024) · Bioconjugate Chemistry · doi:10.1021/acs.bioconjchem.4c00155 · Cited by 1 · see citing works

Molecular Imaging Agent Design for Quantifying Beta Cell Mass in Type 1 Diabetes

Zhang, L. (2017) · Deep Blue (University of Michigan)

Synthesis of In-Tether Chiral Center Peptides and Their Biophysical Properties Study

Hu, K. (2021) · Springer theses · doi:10.1007/978-981-33-6613-8_2

Introduction

Hu, K. (2021) · Springer theses · doi:10.1007/978-981-33-6613-8_1

Properties of Stabilized Peptides

Li, Z., Zhao, H., & Wan, C. (2021) · doi:10.1002/9783527343430.ch3

Stapled peptides for new drug discovery

Liu, C., Wang, N., Chen, B., & Hu, H. (2023) · Elsevier eBooks · doi:10.1016/b978-0-443-18611-0.00003-6

Design and characterization of new pyridazine materials for OLEDs and OSLs applications

Li, H. (2021) · doi:10.70675/e6ca3726z6977z407czba48z25bf033f25c9

BindingDB Entry 50012111: hDM2 protein-binding peptides screened from stapled α-helical peptide phage display libraries with different types of staple linkers.

BindingDB (2022) · UC San Diego · doi:10.7270/q2c82dz2

Rational Design of Proteolytically Stable, Cell-Permeable Peptide-Based Selective Mcl-1 Inhibitors

Muppidi, A., Doi, K., Edwardraja, S., Drake, E. J., Gulick, A. M., Wang, H.-G., & Lin, Q. (2012) · Journal of the American Chemical Society · doi:10.1021/ja306864v · Cited by 156 · see citing works

Synthesis of cell-permeable stapled BH3 peptide-based Mcl-1 inhibitors containing simple aryl and vinylaryl cross-linkers

Muppidi, A., Doi, K., Ramil, C. P., Wang, H., & Lin, Q. (2014) · Tetrahedron · doi:10.1016/j.tet.2014.05.104 · Cited by 30 · see citing works

Cell-Permeable Peptide Inhibitors of the p53-hDM2 Interaction via Foldamer Helix Mimicry and Bis-Thioether Stapling

Neuville, M., Bourgeais, M., Li, B., Varajao, L., Hallé, F., Goudreau, S. R., Thinon, E., Pasco, M., Khatib, A., & Guichard, G. (2024) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.4c01762 · Cited by 9 · see citing works

Interchain doubly-bridged α-helical peptides for the development of protein binders

Chen, Y., Liang, J., Li, T., Lin, P. J., Zhao, Y., & Wu, C. (2019) · Chinese Chemical Letters · doi:10.1016/j.cclet.2019.02.013 · Cited by 3 · see citing works

Synthesis of cell-permeable stapled peptide dual inhibitors of the p53-Mdm2/Mdmx interactions via photoinduced cycloaddition

Madden, M. M., Muppidi, A., Li, Z., Li, X., Chen, J., & Lin, Q. (2011) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2011.01.004 · Cited by 104 · see citing works