The DOI matches its Crossref record; 49 of the 49 references it cites were found in a registry or an index.
Acid-Active Cell-Penetrating Peptides for in Vivo Tumor-Targeted Drug Delivery
Abstract
Cell-penetrating peptides (CPPs) such as transactivator of transcription (TAT) peptide have long been explored for promoting in vitro cell penetration and nuclear targeting of various cargos, but their positive charges cause strong nonspecific interactions, making them inapplicable for many in vivo applications. In this work, we used TAT to demonstrate a molecular modification approach for inhibiting nonspecific interactions of CPPs in the bloodstream while reactivating their functions in the targeted tissues or cells. The TAT lysine residues' amines were amidized to succinyl amides ((a)TAT), completely inhibiting TAT's nonspecific interactions in the blood compartment; once in the acidic tumor interstitium or internalized into cell endo/lysosomes, the succinyl amides in the (a)TAT were quickly hydrolyzed, fully restoring TAT's functions. Thus, (a)TAT-functionalized poly(ethylene glycol)-block-poly(ε-caprolactone) micelles achieved long circulation in the blood compartment and efficiently accumulated and delivered doxorubicin to tumor tissues, giving rise to high antitumor activity and low cardiotoxicity. This amidization strategy effectively and easily enables in vivo applications of CPPs.
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Self-citationPrecise nanomedicine for intelligent therapy of cancer
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Metadata
- Authors
- Jin, E., Zhang, B., Sun, X., Zhou, Z., Ma, X., Sun, Q., Tang, J., Shen, Y., Van Kirk, E., Murdoch, W. J., & Radosz, M.
- Venue
- Journal of the American Chemical Society
- Publisher
- American Chemical Society (ACS)
- Published
- 2013-01-07
- Volume
- 135
- Issue
- 2
- Pages
- 933-940
- ISSN
- 0002-7863 (ISSN-L)
- 1520-5126
- OpenAlex
- W2052758340
- Cited by
- 329
- References
- 49
- FWCI
- 8.78
- Type
- journal article
- Language
- en
- Open access
- closed
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- Jin, E., Zhang, B., Sun, X., Zhou, Z., Ma, X., Sun, Q., Tang, J., Shen, Y., Van Kirk, E., Murdoch, W. J., & Radosz, M. (2013). Acid-Active Cell-Penetrating Peptides for in Vivo Tumor-Targeted Drug Delivery. Journal of the American Chemical Society. https://doi.org/10.1021/ja311180x
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