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Target-Responsive “Sweet” Hydrogel with Glucometer Readout for Portable and Quantitative Detection of Non-Glucose Targets
Abstract
Portable devices with the advantages of rapid, on-site, user-friendly, and cost-effective assessment are widely applied in daily life. However, only a limited number of quantitative portable devices are commercially available, among which the personal glucose meter (PGM) is the most successful example and has been the most widely used. However, PGMs can detect only blood glucose as the unique target. Here we describe a novel design that combines a glucoamylase-trapped aptamer-cross-linked hydrogel with a PGM for portable and quantitative detection of non-glucose targets. Upon target introduction, the hydrogel collapses to release glucoamylase, which catalyzes the hydrolysis of amylose to produce a large amount of glucose for quantitative readout by the PGM. With the advantages of low cost, rapidity, portability, and ease of use, the method reported here has the potential to be used by the public for portable and quantitative detection of a wide range of non-glucose targets.
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Shen, F., Sun, B., Kreutz, J. E., Davydova, E. K., Du, W., Reddy, P. L., Joseph, L. J., & Ismagilov, R. F. (2011) · Journal of the American Chemical Society · doi:10.1021/ja2060116 · Cited by 231
Cited by
Paper Electrode-Based Flexible Pressure Sensor for Point-of-Care Immunoassay with Digital Multimeter
Yu, Z., Tang, Y., Cai, G., Ren, R., & Tang, D. (2019) · Analytical Chemistry · doi:10.1021/acs.analchem.8b04635 · Cited by 341
Metadata
- Authors
- Yan, L., Zhu, Z., Zou, Y., Huang, Y., Liu, D., Jia, S., Xu, D., Wu, M., Zhou, Y., Zhou, S., & Yang, C. J.
- Venue
- Journal of the American Chemical Society
- Publisher
- American Chemical Society (ACS)
- Published
- 2013-01-29
- Volume
- 135
- Issue
- 10
- Pages
- 3748-3751
- ISSN
- 0002-7863 (ISSN-L)
- 1520-5126
- OpenAlex
- W2325415030
- Cited by
- 329
- References
- 1
- FWCI
- 13.99
- Type
- journal article
- Language
- en
- Open access
- closed
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- The paper
- Yan, L., Zhu, Z., Zou, Y., Huang, Y., Liu, D., Jia, S., Xu, D., Wu, M., Zhou, Y., Zhou, S., & Yang, C. J. (2013). Target-Responsive “Sweet” Hydrogel with Glucometer Readout for Portable and Quantitative Detection of Non-Glucose Targets. Journal of the American Chemical Society. https://doi.org/10.1021/ja3114714
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