The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Controllable Drug Release and Simultaneously Carrier Decomposition of SiO2-Drug Composite Nanoparticles
Abstract
Drug release simultaneously with carrier decomposition has been demonstrated in SiO2-drug composite nanoparticles. By creating a radial drug concentration gradient in the nanoparticle, controllable release of the drug is primarily driven by diffusion. Escape of the drug molecules then triggers the SiO2 carrier decomposition, which starts from the center of the nanoparticle and eventually leads to its complete fragmentation. The small size of the final carrier fragments enables their easy excretion via renal systems. Together with the known biocompatibility of SiO2, the feature of controllable drug release and simultaneous carrier decomposition achieved in the SiO2-drug nanoparticles make it ideal for a wide range of diagnostic and therapeutic applications with great promise for potential clinical translation.
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Cites
Recent advances with liposomes as pharmaceutical carriers
Torchilin, V. P. (2005) · Nature Reviews Drug Discovery · doi:10.1038/nrd1632 · Cited by 5,282
Renal clearance of quantum dots
Soo Choi, H., Liu, W., Misra, P., Tanaka, E., Zimmer, J. P., Itty Ipe, B., Bawendi, M. G., & Frangioni, J. V. (2007) · Nature Biotechnology · doi:10.1038/nbt1340 · Cited by 4,476
5-Aminolevulinic Acid-Conjugated Gold Nanoparticles for Photodynamic Therapy of Cancer
Khaing Oo, M. K., Yang, X., Du, H., & Wang, H. (2008) · Nanomedicine · doi:10.2217/17435889.3.6.777 · Cited by 113
Cited by
Croissant, J. G., Fatieiev, Y., & Khashab, N. M. (2017) · Advanced Materials · doi:10.1002/adma.201604634 · Cited by 782
Croissant, J. G., Fatieiev, Y., Almalik, A., & Khashab, N. M. (2018) · Advanced Healthcare Materials · doi:10.1002/adhm.201700831 · Cited by 594
Inorganic nanomaterials with rapid clearance for biomedical applications
Wang, X., Zhong, X., Li, J., Liu, Z., & Cheng, L. (2021) · Chemical Society Reviews · doi:10.1039/d0cs00461h · Cited by 509
Versatile Types of Organic/Inorganic Nanohybrids: From Strategic Design to Biomedical Applications
Zhao, N., Yan, L., Zhao, X., Chen, X., Li, A., Zheng, D., Zhou, X., Dai, X., & Xu, F.-J. (2019) · Chemical Reviews · doi:10.1021/acs.chemrev.8b00401 · Cited by 429
Yu, L., Chen, Y., Wu, M., Cai, X., Yao, H., Zhang, L., Chen, H., & Shi, J. (2016) · Journal of the American Chemical Society · doi:10.1021/jacs.6b04299 · Cited by 305
Metadata
- Authors
- Zhang, S., Chu, Z., Yin, C., Zhang, C., Lin, G., & Li, Q.
- Venue
- Journal of the American Chemical Society
- Publisher
- American Chemical Society (ACS)
- Published
- 2013-04-05
- Volume
- 135
- Issue
- 15
- Pages
- 5709-5716
- ISSN
- 0002-7863 (ISSN-L)
- 1520-5126
- OpenAlex
- W2324198878
- Cited by
- 224
- References
- 3
- FWCI
- 8.87
- Type
- journal article
- Language
- en
- Open access
- closed
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- Zhang, S., Chu, Z., Yin, C., Zhang, C., Lin, G., & Li, Q. (2013). Controllable Drug Release and Simultaneously Carrier Decomposition of SiO2-Drug Composite Nanoparticles. Journal of the American Chemical Society. https://doi.org/10.1021/ja3123015
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