The DOI matches its Crossref record; 27 of the 27 references it cites were found in a registry or an index.
Chiral Selective Transmembrane Transport of Amino Acids through Artificial Channels
Abstract
Peptide-appended pillar[n]arene (n = 5, 6) derivatives have been synthesized. (1)H NMR and IR studies revealed that the molecules adopt a tubular conformation in solution and lipid bilayer membranes. Kinetic measurements using the fluorescent labeling method with lipid vesicles revealed that these molecules can efficiently mediate the transport of amino acids across lipid membranes at a very low channel-to-lipid ratio (EC(50) = 0.002 mol %). In several cases, chiral selectivity for amino acid enantiomers was achieved, which is one of the key functions of natural amino acid channels.
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Cites
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Pillararenes, A New Class of Macrocycles for Supramolecular Chemistry
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Amino Acid Transport Across Mammalian Intestinal and Renal Epithelia
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Self-assembly of amphiphilic dendritic dipeptides into helical pores
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Cited by
Yashima, E., Ousaka, N., Taura, D., Shimomura, K., Ikai, T., & Maeda, K. (2016) · Chemical Reviews · doi:10.1021/acs.chemrev.6b00354 · Cited by 2,004
Xia, D., Wang, P., Ji, X., Khashab, N. M., Sessler, J. L., & Huang, F. (2020) · Chemical Reviews · doi:10.1021/acs.chemrev.9b00839 · Cited by 734
A tuneable minimal cell membrane reveals that two lipid species suffice for life
Justice, I., Kiesel, P., Safronova, N., von Appen, A., & Saenz, J. P. (2023) · doi:10.1101/2023.10.24.563757 · Cited by 41
A tuneable minimal cell membrane reveals that two lipid species suffice for life
Justice, I., Kiesel, P., Safronova, N., von Appen, A., & Saenz, J. P. (2024) · Nature Communications · doi:10.1038/s41467-024-53975-y · Cited by 41
Metadata
- Authors
- Chen, L., Si, W., Zhang, L., Tang, G., Li, Z.-T., & Hou, J.-L.
- Venue
- Journal of the American Chemical Society
- Publisher
- American Chemical Society (ACS)
- Published
- 2013-02-01
- Volume
- 135
- Issue
- 6
- Pages
- 2152-2155
- ISSN
- 0002-7863 (ISSN-L)
- 1520-5126
- OpenAlex
- W2050808068
- Cited by
- 305
- References
- 27
- FWCI
- 13.10
- Type
- journal article
- Language
- en
- Open access
- closed
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- Chen, L., Si, W., Zhang, L., Tang, G., Li, Z.-T., & Hou, J.-L. (2013). Chiral Selective Transmembrane Transport of Amino Acids through Artificial Channels. Journal of the American Chemical Society. https://doi.org/10.1021/ja312704e
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