The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
A Targeted, Self-Delivered, and Photocontrolled Molecular Beacon for mRNA Detection in Living Cells
Open accessAbstract
The spatiotemporal dynamics of specific mRNA molecules are difficult to image and detect inside living cells, and this has been a significant challenge for the chemical and biomedical communities. To solve this problem, we have developed a targeted, self-delivered, and photocontrolled aptamer-based molecular beacon (MB) for intracellular mRNA analysis. An internalizing aptamer connected via a double-stranded DNA structure was used as a carrier probe (CP) for cell-specific delivery of the MB designed to signal target mRNA. A light activation strategy was employed by inserting two photolabile groups in the CP sequence, enabling control over the MB's intracellular function. After the probe was guided to the target cell via specific binding of aptamer AS1411 to nucleolin on the cell membrane, light illumination released the MB for mRNA monitoring. Consequently, the MB is able to perform live-cell mRNA imaging with precise spatiotemporal control, while the CP acts as both a tracer for intracellular distribution of the MB before photoinitiation and an internal reference for mRNA ratiometric detection.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Single-allele analysis of transcription kinetics in living mammalian cells
Yunger, S., Rosenfeld, L., Garini, Y., & Shav-Tal, Y. (2010) · Nature Methods · doi:10.1038/nmeth.1482 · Cited by 170
Cited by
Aptamer-integrated DNA nanostructures for biosensing, bioimaging and cancer therapy
Meng, H.-M., Liu, H., Kuai, H., Peng, R., Mo, L., & Zhang, X.-B. (2016) · Chemical Society Reviews · doi:10.1039/c5cs00645g · Cited by 608
Optochemical Control of Biological Processes in Cells and Animals
Ankenbruck, N., Courtney, T., Naro, Y., & Deiters, A. (2018) · Angewandte Chemie International Edition · doi:10.1002/anie.201700171 · Cited by 419
Advancement of the emerging field of RNA nanotechnology
Jasinski, D., Haque, F., Binzel, D. W., & Guo, P. (2017) · ACS Nano · doi:10.1021/acsnano.6b05737 · Cited by 352
Wu, C., Cansiz, S., Zhang, L., Teng, I.-T., Qiu, L., Li, J., Liu, Y., Zhou, C., Hu, R., Zhang, T., et al. (2015) · Journal of the American Chemical Society · doi:10.1021/jacs.5b00542 · Cited by 332
Self-citationZhao, J., Chu, H., Zhao, Y., Lu, Y., & Li, L. (2019) · Journal of the American Chemical Society · doi:10.1021/jacs.9b01931 · Cited by 287
Metadata
- Authors
- Qiu, L., Wu, C., You, M., Han, D., Chen, T., Zhu, G., Jiang, J., Yu, R., & Tan, W.
- Venue
- Journal of the American Chemical Society
- Publisher
- American Chemical Society (ACS)
- Published
- 2013-08-21
- Volume
- 135
- Issue
- 35
- Pages
- 12952-12955
- ISSN
- 0002-7863 (ISSN-L)
- 1520-5126
- OpenAlex
- W2084311353
- Cited by
- 208
- References
- 1
- FWCI
- 7.13
- Type
- journal article
- Language
- en
- Open access
- green
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: A Targeted, Self-Delivered, and Photocontrolled Molecular Beacon for mRNA Detection in Living Cells. https://app.cochat.ai/papers/10.1021/ja406252w
- The paper
- Qiu, L., Wu, C., You, M., Han, D., Chen, T., Zhu, G., Jiang, J., Yu, R., & Tan, W. (2013). A Targeted, Self-Delivered, and Photocontrolled Molecular Beacon for mRNA Detection in Living Cells. Journal of the American Chemical Society. https://doi.org/10.1021/ja406252w
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
