The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Photodegradable Supramolecular Hydrogels with Fluorescence Turn-On Reporter for Photomodulation of Cellular Microenvironments
Abstract
Photodegradable hydrogels that allow 3D encapsulation of cells are important biomaterials to modulate cellular microenvironments with temporal and spatial resolution. Herein we report a photodegradable hydrogel formed by the self-assembly of short peptides modified with a novel phototrigger. The phototrigger is a biaryl-substituted tetrazole moiety that, upon mild light irradiation, undergoes rapid intramolecular photoclick ligation to form a highly fluorescent pyrazoline moiety. Short peptides linked with a tetrazole-containing moiety, Tet(I) or Tet(II), are able to self-assemble into hydrogels, among which the Tet(I)-GFF and Tet(II)-GFRGD gels show good mechanical strength and biocompatibility for 3D encapsulation and prolonged culture of live cells. The phototriggered tetrazole-to-pyrazoline transformation generates a highly fluorescent reporter and induces the disassembly of the hydrogel matrix by disturbing the balance between hydrophilic interaction and π-π stacking of the self-assembled system. Photomodulation of cellular microenvironments was demonstrated not only for the cells grown on top of the gel but also for stem cells encapsulated inside the hydrogels.
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Cites
Photodegradable Hydrogels for Dynamic Tuning of Physical and Chemical Properties
Kloxin, A. M., Kasko, A. M., Salinas, C. N., & Anseth, K. S. (2009) · Science · doi:10.1126/science.1169494 · Cited by 1,748
Photoreversible Patterning of Biomolecules within Click‐Based Hydrogels
DeForest, C. A., & Anseth, K. S. (2012) · Angewandte Chemie International Edition · doi:10.1002/anie.201106463 · Cited by 315
Cited by
Supramolecular Hydrogelators and Hydrogels: From Soft Matter to Molecular Biomaterials
Du, X., Zhou, J., Shi, J., & Xu, B. (2015) · Chemical Reviews · doi:10.1021/acs.chemrev.5b00299 · Cited by 1,861
Functional and Biomimetic Materials for Engineering of the Three-Dimensional Cell Microenvironment
Huang, G., Li, F., Zhao, X., Ma, Y., Li, Y., Lin, M., Jin, G., Lu, T. J., Genin, G. M., & Xu, F. (2017) · Chemical Reviews · doi:10.1021/acs.chemrev.7b00094 · Cited by 825
The design of reversible hydrogels to capture extracellular matrix dynamics
Rosales, A. M., & Anseth, K. S. (2016) · Nature Reviews Materials · doi:10.1038/natrevmats.2015.12 · Cited by 772
Scinto, S. L., Bilodeau, D. A., Hincapie, R., Lee, W., Nguyen, S. S., Xu, M., am Ende, C. W., Finn, M. G., Lang, K., Lin, Q., et al. (2021) · Nature Reviews Methods Primers · doi:10.1038/s43586-021-00028-z · Cited by 592
A photoreversible protein-patterning approach for guiding stem cell fate in three-dimensional gels
DeForest, C. A., & Tirrell, D. A. (2015) · Nature Materials · doi:10.1038/nmat4219 · Cited by 432
Metadata
- Authors
- He, M., Li, J., Tan, S., Wang, R., & Zhang, Y.
- Venue
- Journal of the American Chemical Society
- Publisher
- American Chemical Society (ACS)
- Published
- 2013-10-09
- Volume
- 135
- Issue
- 50
- Pages
- 18718-18721
- ISSN
- 0002-7863 (ISSN-L)
- 1520-5126
- OpenAlex
- W2334312060
- Cited by
- 160
- References
- 2
- FWCI
- 7.31
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
