Photoreversible Patterning of Biomolecules within Click‐Based Hydrogels
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Lighting the way: Biochemical cues have been reversibly patterned into hydrogels with full spatiotemporal control by using two photochemical reactions. The hydrogel is conjugated with a peptide by a thiol-ene photoaddition reaction that is initiated by visible light. Subsequent, selective photocleavage of an o-nitrobenzyl ether with UV light enables dynamic presentation of the peptide to cells with control in three dimensions.
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Synthetic hydrogels can be functionalized with biologically active moieties that permit the growth and spread of cells; concentration and spacing of these cues can be changed independently.
“Synthetic hydrogels can be functionalized with biologically active moieties that permit the growth and spread of cells146–151; concentration and spacing of these cues can be changed independently152–155.”
From Towards organoid culture without Matrigel (2021) · cites this paper as [153]
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- Authors
- DeForest, C. A., & Anseth, K. S.
- Affiliations
- Howard Hughes Medical Institute (US)
- Corresponding author
- Anseth, Kristi S.
- Venue
- Angewandte Chemie International Edition
- Publisher
- Wiley
- Published
- 2011-12-08
- Volume
- 51
- Issue
- 8
- Pages
- 1816-1819
- ISSN
- 1433-7851 (ISSN-L)
- 1521-3773
- PMC
- PMC3430005
- OpenAlex
- W2109351872
- Cited by
- 315
- References
- 24
- Citations by year
- 2026: 9 · 2025: 7 · 2024: 12 · 2023: 11 · 2022: 21 · 2021: 23 · 2020: 20 · 2019: 18 · 2018: 38 · 2017: 27 · 2016: 18 · 2015: 22 · 2014: 33 · 2013: 35 · 2012: 21
- FWCI
- 12.99
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Angewandte Chemie International Edition (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- National Science Foundation (1006711)
- Howard Hughes Medical Institute
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Hydrogels: synthesis, properties, applications
- Physical Sciences › Chemistry › Organic Chemistry › Photopolymerization techniques and applications
- Physical Sciences › Chemistry › Organic Chemistry › Click Chemistry and Applications
- Keywords
- hydrogels, click chemistry, peptide conjugation, photocleavage, spatiotemporal control, 3D cell culture
- MeSH terms
- Oligopeptides, Peptides, Molecular Structure, Hydrogels, Photochemical Processes, Click Chemistry
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