The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Enzyme-Responsive Amphiphilic PEG-Dendron Hybrids and Their Assembly into Smart Micellar Nanocarriers
Abstract
Enzyme-responsive micelles have great potential as drug delivery platforms due to the high selectivity of the activating enzymes. Here we report a highly modular design for the efficient and simple synthesis of amphiphilic block copolymers based on a linear hydrophilic polyethyleneglycol (PEG) and an enzyme-responsive hydrophobic dendron. These amphiphilic hybrids self-assemble in water into micellar nanocontainers that can disassemble and release encapsulated molecular cargo upon enzymatic activation. The utilization of monodisperse dendrons as the stimuli-responsive block enabled a detailed kinetic study of the molecular mechanism of the enzymatically triggered disassembly. The modularity of these PEG-dendron hybrids allows control over the disassembly rate of the formed micelles by simply tuning the PEG length. Such smart amphiphilic hybrids could potentially be applied for the fabrication of nanocarriers with adjustable release rates for delivery applications.
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Citations
Cites
Enzyme Sensitive Synthetic Polymer Micelles Based on the Azobenzene Motif
Rao, J., & Khan, A. (2013) · Journal of the American Chemical Society · doi:10.1021/ja407514z · Cited by 207
Cited by
Smart micro/nanoparticles in stimulus-responsive drug/gene delivery systems
Karimi, M., Ghasemi, A., Sahandi Zangabad, P., Rahighi, R., Moosavi Basri, S. M., Mirshekari, H., Amiri, M., Shafaei Pishabad, Z., Aslani, A., Bozorgomid, M., et al. (2016) · Chemical Society Reviews · doi:10.1039/c5cs00798d · Cited by 1,519
Enzyme-responsive nanomaterials for controlled drug delivery
Hu, Q., Katti, P. S., & Gu, Z. (2014) · Nanoscale · doi:10.1039/c4nr04249b · Cited by 668
Mimicking the Cell: Bio-Inspired Functions of Supramolecular Assemblies
Tu, Y., Peng, F., Adawy, A., Men, Y., Abdelmohsen, L. K. E. A., & Wilson, D. A. (2016) · Chemical Reviews · doi:10.1021/acs.chemrev.5b00344 · Cited by 316
Internal stimuli-responsive nanocarriers for drug delivery: Design strategies and applications
Liu, M., Du, H., Zhang, W., & Zhai, G. (2017) · Materials Science and Engineering: C · doi:10.1016/j.msec.2016.11.030 · Cited by 235
The in vivo fate of polymeric micelles
Cai, Y., Qi, J., Lu, Y., He, H., & Wu, W. (2022) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2022.114463 · Cited by 154
Metadata
- Authors
- Harnoy, A. J., Rosenbaum, I., Tirosh, E., Ebenstein, Y., Shaharabani, R., Beck, R., & Amir, R. J.
- Venue
- Journal of the American Chemical Society
- Publisher
- American Chemical Society (ACS)
- Published
- 2014-03-11
- Volume
- 136
- Issue
- 21
- Pages
- 7531-7534
- ISSN
- 0002-7863 (ISSN-L)
- 1520-5126
- OpenAlex
- W2329401847
- Cited by
- 191
- References
- 1
- FWCI
- 15.42
- Type
- journal article
- Language
- en
- Open access
- closed
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