The DOI matches its Crossref record; 95 of the 95 references it cites were found in a registry or an index.
Enzyme-responsive nanomaterials for controlled drug delivery
Open accessAbstract
Enzymes underpin physiological function and exhibit dysregulation in many disease-associated microenvironments and aberrant cell processes. Exploiting altered enzyme activity and expression for diagnostics, drug targeting, and drug release is tremendously promising. When combined with booming research in nanobiotechnology, enzyme-responsive nanomaterials used for controlled drug release have achieved significant development and have been studied as an important class of drug delivery strategies in nanomedicine. In this review, we describe enzymes such as proteases, phospholipases and oxidoreductases that serve as delivery triggers. Subsequently, we explore recently developed enzyme-responsive nanomaterials with versatile applications for extracellular and intracellular drug delivery. We conclude by discussing future opportunities and challenges in this area.
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Cited by
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Recent advances of cocktail chemotherapy by combination drug delivery systems
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Self-citationMoradi Kashkooli, F., Soltani, M., & Souri, M. (2020) · Journal of Controlled Release · doi:10.1016/j.jconrel.2020.08.012 · Cited by 514
Stimuli-Responsive Drug Release from Smart Polymers
Wells, C. M., Harris, M., Choi, L., Murali, V. P., Guerra, F. D., & Jennings, J. A. (2019) · Journal of Functional Biomaterials · doi:10.3390/jfb10030034 · Cited by 341
Metadata
- Authors
- Hu, Q., Katti, P. S., & Gu, Z.
- Venue
- Nanoscale
- Publisher
- Royal Society of Chemistry (RSC)
- Published
- 2014-09-24
- Volume
- 6
- Issue
- 21
- Pages
- 12273-12286
- ISSN
- 2040-3364 (ISSN-L)
- 2040-3372
- OpenAlex
- W2146536848
- Cited by
- 668
- References
- 95
- FWCI
- 10.61
- Type
- journal article
- Language
- en
- Open access
- green
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
