The DOI matches its Crossref record.
Sequence-Defined Polymers via Orthogonal Allyl Acrylamide Building Blocks
Abstract
Biological systems have long recognized the importance of macromolecular diversity and have evolved efficient processes for the rapid synthesis of sequence-defined biopolymers. However, achieving sequence control via synthetic methods has proven to be a difficult challenge. Herein we describe efforts to circumvent this difficulty via the use of orthogonal allyl acrylamide building blocks and a liquid-phase fluorous support for the de novo design and synthesis of sequence-specific polymers. We demonstrate proof-of-concept via synthesis and characterization of two sequence-isomeric 10-mer polymers. (1)H NMR and LCMS were used to confirm their chemical structure while tandem MS was used to confirm sequence identity. Further validation of this methodology was provided via the successful synthesis of a sequence-specific 16-mer polymer incorporating nine different monomers. This strategy thus shows promise as an efficient approach for the assembly of sequence-specific functional polymers.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cited by
Iterative exponential growth of stereo- and sequence-controlled polymers
Barnes, J. C., Ehrlich, D. J. C., Gao, A. X., Leibfarth, F. A., Jiang, Y., Zhou, E., Jamison, T. F., & Johnson, J. A. (2015) · Nature Chemistry · doi:10.1038/nchem.2346 · Cited by 361
Barcoded nanoparticles for high throughput in vivo discovery of targeted therapeutics
Dahlman, J. E., Kauffman, K. J., Xing, Y., Shaw, T. E., Mir, F. F., Dlott, C. C., Langer, R., Anderson, D. G., & Wang, E. T. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1620874114 · Cited by 335
Design and synthesis of digitally encoded polymers that can be decoded and erased
Roy, R. K., Meszynska, A., Laure, C., Charles, L., Verchin, C., & Lutz, J.-F. (2015) · Nature Communications · doi:10.1038/ncomms8237 · Cited by 308
Multifunctional sequence-defined macromolecules for chemical data storage.
Martens, S., Landuyt, A., Espeel, P., Devreese, B., Dawyndt, P., & Du Prez, F. (2018) · Nature Communications · doi:10.1038/s41467-018-06926-3 · Cited by 180
Counting loops in sidechain-crosslinked polymers from elastic solids to single-chain nanoparticles
Wang, J., Wang, R., Gu, Y., Sourakov, A., Olsen, B. D., & Johnson, J. A. (2019) · Chemical Science · doi:10.1039/c9sc01297d · Cited by 48
Metadata
- Authors
- Porel, M., & Alabi, C. A.
- Venue
- Journal of the American Chemical Society
- Publisher
- American Chemical Society (ACS)
- Published
- 2014-09-16
- Volume
- 136
- Issue
- 38
- Pages
- 13162-13165
- ISSN
- 0002-7863 (ISSN-L)
- 1520-5126
- OpenAlex
- W2332864154
- Cited by
- 221
- References
- 0
- FWCI
- 10.26
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Sequence-Defined Polymers via Orthogonal Allyl Acrylamide Building Blocks. https://app.cochat.ai/papers/10.1021/ja507262t
- The paper
- Porel, M., & Alabi, C. A. (2014). Sequence-Defined Polymers via Orthogonal Allyl Acrylamide Building Blocks. Journal of the American Chemical Society. https://doi.org/10.1021/ja507262t
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
