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Cited by 199

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Targeted Paclitaxel by Conjugation to Iron Oxide and Gold Nanoparticles

Hwu, Jih Ru, Lin, Yu Sern, Josephrajan, Thainashmuthu, Hsu, Ming-Hua, Cheng, Fong-Yu, Yeh, Chen-Sheng, Su, Wu-Chou, Shieh, Dar-Bin·2009·Journal of the American Chemical Society

Abstract

The Fe(3)O(4) nanoparticles, tailored with maleimidyl 3-succinimidopropionate ligands, were conjugated with paclitaxel molecules that were attached with a poly(ethylene glycol) (PEG) spacer through a phosphodiester moiety at the (C-2')-OH position. The average number of paclitaxel molecules/nanoparticles was determined as 83. These nanoparticles liberated paclitaxel molecules upon exposure to phosphodiesterase.

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Metadata

Authors
Hwu, J. R., Lin, Y. S., Josephrajan, T., Hsu, M.-H., Cheng, F.-Y., Yeh, C.-S., Su, W.-C., & Shieh, D.-B.
Venue
Journal of the American Chemical Society
Published
2008-12-10
Volume
131
Issue
1
Pages
66-68
ISSN
  • 0002-7863 (ISSN-L)
  • 1520-5126
OpenAlex
W2083790799
Cited by
199
References
0
FWCI
5.18
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Targeted Paclitaxel by Conjugation to Iron Oxide and Gold Nanoparticles. https://app.cochat.ai/papers/10.1021/ja804947u
The paper
Hwu, J. R., Lin, Y. S., Josephrajan, T., Hsu, M.-H., Cheng, F.-Y., Yeh, C.-S., Su, W.-C., & Shieh, D.-B. (2009). Targeted Paclitaxel by Conjugation to Iron Oxide and Gold Nanoparticles. Journal of the American Chemical Society. https://doi.org/10.1021/ja804947u

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.