The biological properties of iron oxide core high-density lipoprotein in experimental atherosclerosis
Open accessAbstract
Lipoproteins are a family of plasma nanoparticles responsible for the transportation of lipids throughout the body. High-density lipoprotein (HDL), the smallest of the lipoprotein family, measures 7-13 nm in diameter and consists of a cholesteryl ester and triglyceride core that is covered with a monolayer of phospholipids and apolipoproteins. We have developed an iron oxide core HDL nanoparticle (FeO-HDL), which has a lipid based fluorophore incorporated in the phospholipid layer. This nanoparticle provides contrast for optical imaging, magnetic resonance imaging (MRI) and transmission electron microscopy (TEM). Consequently, FeO-HDL can be visualized on the anatomical, cellular and sub-cellular level. In the current study we show that the biophysical features of FeO-HDL closely resemble those of native HDL and that FeO-HDL possess the ability to mimic HDL characteristics both in vitro as well as in vivo. We demonstrate that FeO-HDL can be applied to image HDL interactions and to investigate disease settings where HDL plays a key function. More generally, we have demonstrated a multimodal approach to study the behavior of biomaterials in vitro as well as in vivo. The approach allowed us to study nanoparticle dynamics in circulation, as well as nanoparticle targeting and uptake by tissues and cells of interest. Moreover, we were able to qualitatively assess nanoparticle excretion, critical for translating nanotechnologies to the clinic.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Biomimetic HDL nanoparticles incorporating gold nanocrystals or iron oxide have biophysical features closely resembling native HDL and similar cholesterol binding and efflux capabilities.
“Biomimetic HDL nanoparticles incorporating gold nanocrystals (Au–HDL) and iron oxide (FeO–HDL) have biophysical features that closely resemble those of native HDL, and have similar cholesterol binding and cholesterol efflux capabilities71,72.”
From Perspectives and opportunities for nanomedicine in the management of atherosclerosis (2011) · cites this paper as [72]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Havel, R. J., Eder, H. A., & Bragdon, J. H. (1955) · Journal of Clinical Investigation · doi:10.1172/jci103182 · Cited by 8,756 · see citing works
Lusis, A. J. (2000) · Nature · doi:10.1038/35025203 · Cited by 4,880 · see citing works
Renal clearance of quantum dots
Soo Choi, H., Liu, W., Misra, P., Tanaka, E., Zimmer, J. P., Itty Ipe, B., Bawendi, M. G., & Frangioni, J. V. (2007) · Nature Biotechnology · doi:10.1038/nbt1340 · Cited by 4,476 · see citing works
From Vulnerable Plaque to Vulnerable Patient
Naghavi, M., Libby, P., Falk, E., Casscells, S. W., Litovsky, S. H., Rumberger, J. A., Badimón, J. J., Stefanadis, C., Moreno, P., Pasterkamp, G., et al. (2003) · Circulation · doi:10.1161/01.cir.0000087481.55887.c9 · Cited by 2,686 · see citing works
Self-citationIdentification of Scavenger Receptor SR-BI as a High Density Lipoprotein Receptor
Acton, S. L., Rigotti, A., Landschulz, K. T., Xu, S., Hobbs, H. H., & Krieger, M. (1996) · Science · doi:10.1126/science.271.5248.518 · Cited by 2,347 · see citing works
Plasma lipoproteins: apolipoprotein structure and function.
Mahley, R. W., Innerarity, T. L., Rall, S. C., & Weisgraber, K. H. (1984) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)34443-6 · Cited by 1,155 · see citing works
Mouse Models of Atherosclerosis
Breslow, J. L. (1996) · Science · doi:10.1126/science.272.5262.685 · Cited by 699 · see citing works
Seven challenges for nanomedicine
Sanhai, W. R., Sakamoto, J. H., Canady, R., & Mauro Ferrari, B. (2008) · Nature Nanotechnology · doi:10.1038/nnano.2008.114 · Cited by 538 · see citing works
Mouse Models for Atherosclerosis and Pharmaceutical Modifiers
Zadelaar, S., Kleemann, R., Verschuren, L., der Weij, J. D. V.-V., van der Hoorn, J., Princen, H. M. G., & Kooistra, T. (2007) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.107.142570 · Cited by 526 · see citing works
Cell cholesterol efflux: integration of old and new observations provides new insights
Rothblat, G. H., de la Llera-Moya, M., Atger, V., Kellner-Weibel, G., Williams, D. L., & Phillips, M. C. (1999) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)32113-1 · Cited by 502 · see citing works
Tall, A. R. (2008) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.2007.01898.x · Cited by 436 · see citing works
A Detailed Molecular Belt Model for Apolipoprotein A-I in Discoidal High Density Lipoprotein
Segrest, J. P., Jones, M. K., Klon, A. E., Sheldahl, C., Hellinger, M., Loof, H. D., & Harvey, S. C. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.45.31755 · Cited by 341 · see citing works
Nanocrystal Core High-Density Lipoproteins: A Multimodality Contrast Agent Platform
Cormode, D. P., Skajaa, T., van Schooneveld, M. M., Koole, R., Jarzyna, P., Lobatto, M. E., Calcagno, C., Barazza, A., Gordon, R. E., Zanzonico, P., et al. (2008) · Nano Letters · doi:10.1021/nl801958b · Cited by 328 · see citing works
Self-citationHigh density lipoproteins (HDLs) and atherosclerosis; the unanswered questions
Barter, P. J., Kastelein, J. J. P., Nunn, A. V. W., & Hobbs, R. F. (2003) · Atherosclerosis · doi:10.1016/s0021-9150(03)00006-6 · Cited by 239 · see citing works
[26] Electron microscopy of negatively stained lipoproteins
Forte, T. M., & Nordhausen, R. W. (1986) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/0076-6879(86)28086-6 · Cited by 233 · see citing works
Datta, G., Chaddha, M., Hama, S. Y., Navab, M., Fogelman, A. M., Garber, D. W., Mishra, V., Epand, R. M., Epand, R. F., Lund‐Katz, S., et al. (2001) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)31599-6 · Cited by 222 · see citing works
Structure of apolipoprotein A-I in spherical high density lipoproteins of different sizes
Silva, R. A. G. D., Huang, R., Morris, J. C., Fang, J., Gracheva, E. O., Ren, G., Kontush, A., Jerome, W. G., Rye, K., & Davidson, W. S. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0803626105 · Cited by 206 · see citing works
Multiple actions of high-density lipoprotein
Florentin, M., Liberopoulos, E. N., Wierzbicki, A. S., & Mikhailidis, D. P. (2008) · Current Opinion in Cardiology · doi:10.1097/hco.0b013e3283043806 · Cited by 200 · see citing works
Remaley, A. T., Fairwell, T., Stonik, J. A., Demosky, S. J., Bark, S. E., Neufeld, E. B., Bocharov, A. V., Vishnyakova, T. G., Patterson, A. P., Eggerman, T. L., et al. (2003) · Journal of Lipid Research · doi:10.1194/jlr.m200475-jlr200 · Cited by 195 · see citing works
Bruns†, O. T., Ittrich, H., Peldschus, K., Kaul, M. G., Tromsdorf, U. I., Lauterwasser, J., Nikolić, M. S., Mollwitz†, B., Merkel, M., Bigall, N. C., et al. (2009) · Nature Nanotechnology · doi:10.1038/nnano.2008.405 · Cited by 165 · see citing works
d -Mannose-Modified Iron Oxide Nanoparticles for Stem Cell Labeling
Horák, D., Babič, M., Jendelová, P., Herynek, V., Trchová, M., Pientka, Z., Pollert, E., Hájek, M., & Syková, E. (2007) · Bioconjugate Chemistry · doi:10.1021/bc060186c · Cited by 135 · see citing works
Templated Spherical High Density Lipoprotein Nanoparticles
Thaxton, C. S., Daniel, W. L., Giljohann, D. A., Thomas, A. D., & Mirkin, C. A. (2009) · Journal of the American Chemical Society · doi:10.1021/ja808856z · Cited by 122 · see citing works
Cormode, D. P., Briley-Saebo, K. C., Mulder, W. J. M., Aguinaldo, J. G. S., Barazza, A., Ma, Y., Fisher, E. A. A., & Fayad, Z. A. (2008) · Small · doi:10.1002/smll.200701285 · Cited by 107 · see citing works
Self-citationThree-dimensional models of HDL apoA-I: implications for its assembly and function
Thomas, M. J., Bhat, S., & Sorci‐Thomas, M. G. (2008) · Journal of Lipid Research · doi:10.1194/jlr.r800010-jlr200 · Cited by 107 · see citing works
Atheroprotective Effects of HDL: Beyond Reverse Cholesterol Transport
Fisher, E. A. A., Feig, J. E., & Shamir, R. (2008) · Current Drug Targets · doi:10.2174/138945008783755557 · Cited by 86 · see citing works
Self-citationDavidson, W. S., Lund‐Katz, S., Johnson, W. J., Anantharamaiah, G. M., Palgunachari, M. N., Segrest, J. P., Rothblat, G. H., & Phillips, M. C. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)31606-x · Cited by 74 · see citing works
ApoA-I Structure on Discs and Spheres
Li, H., Lyles, D. S., Pan, W., Alexander, E. T., Thomas, M. J., & Sorci‐Thomas, M. G. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m206770200 · Cited by 69 · see citing works
Rong, J. X., Kusunoki, J., Oelkers, P. M., Sturley, S. L., & Fisher, E. A. A. (2004) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000148202.49842.3b · Cited by 35 · see citing works
Self-citationJonas, A. M. (1979) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)40010-0 · Cited by 32 · see citing works
Viles-González, J. F., Fuster, V., Corti, R., & Badimón, J. J. (2003) · Current Opinion in Cardiology · doi:10.1097/00001573-200307000-00008 · Cited by 25 · see citing works
Flagged first, then by citations
1 of the 31 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Nanoparticle–liver interactions: Cellular uptake and hepatobiliary elimination
Zhang, Y.-N., Poon, W., Tavares, A. J., McGilvray, I. D., & Chan, W. C. W. (2016) · Journal of Controlled Release · doi:10.1016/j.jconrel.2016.01.020 · Cited by 1,358 · see citing works
Imaging macrophages with nanoparticles
Weissleder, R., Nahrendorf, M., & Pittet, M. J. (2014) · Nature Materials · doi:10.1038/nmat3780 · Cited by 809 · see citing works
Duivenvoorden, R., Tang, J., Cormode, D. P., Mieszawska, A. J., Izquierdo‐Garcia, D., Ozcan, C., Otten, M. J., Zaidi, N., Lobatto, M. E., van Rijs, S. M., et al. (2014) · Nature Communications · doi:10.1038/ncomms4065 · Cited by 442 · see citing works
Self-citationPerspectives and opportunities for nanomedicine in the management of atherosclerosis
Lobatto, M. E., Fuster, V., Fayad, Z. A., & Mulder, W. J. M. (2011) · Nature Reviews Drug Discovery · doi:10.1038/nrd3578 · Cited by 423 · see citing works
Self-citationHigh-Density Lipoproteins: Nature’s Multifunctional Nanoparticles
Kuai, R., Li, D., Chen, Y. E., Moon, J. J., & Schwendeman, A. A. (2016) · ACS Nano · doi:10.1021/acsnano.5b07522 · Cited by 341 · see citing works
Iron Oxide Nanoparticles in Regenerative Medicine and Tissue Engineering
Friedrich, R. P., Cicha, I., & Alexiou, C. (2021) · Nanomaterials · doi:10.3390/nano11092337 · Cited by 153 · see citing works
Perturbation of physiological systems by nanoparticles
Zhang, Y., Bai, Y., Jia, J., Gao, N., Li, Y., Zhang, R., Jiang, G., & Yan, B. (2014) · Chemical Society Reviews · doi:10.1039/c3cs60338e · Cited by 150 · see citing works
Lipoproteins and lipoprotein mimetics for imaging and drug delivery
Thaxton, C. S., Rink, J. S., Naha, P. C., & Cormode, D. P. (2016) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2016.04.020 · Cited by 137 · see citing works
Self-citationBiomimetic High Density Lipoprotein Nanoparticles For Nucleic Acid Delivery
McMahon, K. M., Mutharasan, R. K., Tripathy, S., Veliceasa, D., Bobeica, M., Shumaker, D. K., Luthi, A. J., Helfand, B. T., Ardehali, H., Mirkin, C. A., et al. (2011) · Nano Letters · doi:10.1021/nl1041947 · Cited by 124 · see citing works
Kim, Y., Fay, F., Cormode, D. P., Sánchez-Gaytán, B. L., Tang, J., Hennessy, E. J., Ma, M., Moore, K. J., Farokhzad, O. C., Fisher, E. A. A., et al. (2013) · ACS Nano · doi:10.1021/nn4039063 · Cited by 123 · see citing works
Self-citationTemplated high density lipoprotein nanoparticles as potential therapies and for molecular delivery
Damiano, M. G., Mutharasan, R. K., Tripathy, S., McMahon, K. M., & Thaxton, C. S. (2012) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2012.07.013 · Cited by 117 · see citing works
Anti-atherosclerotic therapies: Milestones, challenges, and emerging innovations
Hetherington, I., & Totary-Jain, H. (2022) · Molecular Therapy · doi:10.1016/j.ymthe.2022.08.024 · Cited by 116 · see citing works
Jin, H., Qian, Y., Dai, Y., Qiao, S., Huang, C., Lu, L., Luo, Q., Chen, J., & Zhang, Z. (2016) · Theranostics · doi:10.7150/thno.15102 · Cited by 99 · see citing works
Naha, P. C., Lau, K. C., Hsu, J. C., Hajfathalian, M., Mian, S., Chhour, P., Uppuluri, L., McDonald, E. S., Maidment, A. D. A., & Cormode, D. P. (2016) · Nanoscale · doi:10.1039/c6nr02618d · Cited by 94 · see citing works
Self-citationHarisa, G. I., & Alanazi, F. K. (2013) · Saudi Pharmaceutical Journal · doi:10.1016/j.jsps.2013.12.015 · Cited by 91 · see citing works
Zhang, W., He, H., Liu, J., Wang, J., Zhang, S., Zhang, S., & Wu, Z. (2012) · Biomaterials · doi:10.1016/j.biomaterials.2012.09.058 · Cited by 89 · see citing works
High-Density Lipoprotein Nanobiologics for Precision Medicine
Mulder, W. J. M., van Leent, M. M. T., Lameijer, M., Fisher, E. A. A., Fayad, Z. A., & Pérez‐Medina, C. (2017) · Accounts of Chemical Research · doi:10.1021/acs.accounts.7b00339 · Cited by 86 · see citing works
Self-citationThe Janus of Protein Corona on nanoparticles for tumor targeting, immunotherapy and diagnosis
Wang, X., & Zhang, W. (2022) · Journal of Controlled Release · doi:10.1016/j.jconrel.2022.03.056 · Cited by 81 · see citing works
Luthi, A. J., Zhang, H., Kim, D., Giljohann, D. A., Mirkin, C. A., & Thaxton, C. S. (2011) · ACS Nano · doi:10.1021/nn2035457 · Cited by 72 · see citing works
Jayapaul, J., Hodenius, M., Arns, S., Lederle, W., Lammers, T., Comba, P., Kiessling, F. M., & Gätjens, J. (2011) · Biomaterials · doi:10.1016/j.biomaterials.2011.04.056 · Cited by 69 · see citing works
Lipoprotein-Related and Apolipoprotein-Mediated Delivery Systems for Drug Targeting and Imaging
Almer, G., Mangge, H., Zimmer, A., & Prassl, R. (2015) · Current Medicinal Chemistry · doi:10.2174/0929867322666150716114625 · Cited by 59 · see citing works
Reconstituted HDL: Drug Delivery Platform for Overcoming Biological Barriers to Cancer Therapy
Raut, S., Mooberry, L. K., Sabnis, N. A., Garud, A., Dossou, A. S., & Lacko, A. G. (2018) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.01154 · Cited by 58 · see citing works
Nanomedicines for endothelial disorders
Chung, B. L., Toth, M. J., Kamaly, N., Sei, Y. J., Becraft, J. R., Mulder, W. J. M., Fayad, Z. A., Farokhzad, O. C., Kim, Y., & Langer, R. (2015) · Nano Today · doi:10.1016/j.nantod.2015.11.009 · Cited by 58 · see citing works
Self-citationHigh density lipoprotein mimicking nanoparticles for atherosclerosis
Chen, J., Zhang, X., Millican, R. C., Creutzmann, J. E., Martin, S., & Jun, H. (2020) · Nano Convergence · doi:10.1186/s40580-019-0214-1 · Cited by 57 · see citing works
Cormode, D. P., Sánchez-Gaytán, B. L., Mieszawska, A. J., Fayad, Z. A., & Mulder, W. J. M. (2013) · NMR in Biomedicine · doi:10.1002/nbm.2909 · Cited by 54 · see citing works
Self-citationDevelopment and Application of a Multimodal Contrast Agent for SPECT/CT Hybrid Imaging
Criscione, J. M., Dobrucki, L. W., Zhuang, Z. W., Papademetris, X., Simons, M., Sinusas, A. J., & Fahmy, T. M. (2011) · Bioconjugate Chemistry · doi:10.1021/bc200162r · Cited by 55 · see citing works
Dou, Y., Guo, J., Chen, Y., Han, S., Xu, X., Shi, Q., Jia, Y., Liu, Y., Deng, Y., Wang, R., et al. (2016) · Journal of Controlled Release · doi:10.1016/j.jconrel.2016.05.049 · Cited by 54 · see citing works
Nandwana, V., Ryoo, S., Kanthala, S., McMahon, K. M., Rink, J. S., Li, Y., Venkatraman, S. S., Thaxton, C. S., & Dravid, V. P. (2017) · Chemistry of Materials · doi:10.1021/acs.chemmater.6b05357 · Cited by 54 · see citing works
Mei, Y., Tang, L., Xiao, Q., Zhang, Z., Zhang, Z., Zang, J., Zhou, J., Wang, Y., Wang, W., & Ren, M. (2020) · Journal of Materials Chemistry B · doi:10.1039/d0tb02139c · Cited by 49 · see citing works
Artificial High Density Lipoprotein Nanoparticles in Cardiovascular Research
Kornmueller, K., Vidaković, I., & Prassl, R. (2019) · Molecules · doi:10.3390/molecules24152829 · Cited by 48 · see citing works
Corbin, I. R., Ng, K. K., Ding, L., Jurisicova, A., & Zheng, G. (2012) · Nanomedicine · doi:10.2217/nnm.12.137 · Cited by 43 · see citing works
Chhour, P., Gallo, N. R., Cheheltani, R., Williams, D., Al-Zaki, A., Paik, T., Nichol, J. L., Tian, Z., Naha, P. C., Witschey, W. R. T., et al. (2014) · ACS Nano · doi:10.1021/nn502730q · Cited by 42 · see citing works
Self-citationIron oxide nanoparticles enhancing magnetic resonance imaging: A review of the latest advancements
Aboushoushah, S. F. O. (2025) · Journal of Science Advanced Materials and Devices · doi:10.1016/j.jsamd.2025.100875 · Cited by 41 · see citing works
Zhang, W., Xiao, Y., Liu, J., Wu, Z., Gu, X. Q., Xu, Y., & Lu, H. (2011) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2011.07.039 · Cited by 41 · see citing works
Design strategies of hybrid metallic nanoparticles for theragnostic applications
Gautier, J., Allard-Vannier, É., Hervé-Aubert, K., Soucé, M., & Chourpa, I. (2013) · Nanotechnology · doi:10.1088/0957-4484/24/43/432002 · Cited by 39 · see citing works
Cohen, D., Mashiach, R., Houben, L., Gálisová, A., Addadi, Y., Kain, D., Lubart, A., Blinder, P., Allouche‐Arnon, H., & Bar‐Shir, A. (2021) · ACS Nano · doi:10.1021/acsnano.1c01040 · Cited by 35 · see citing works
Groner, J., Göpferich, A. M., & Breunig, M. (2021) · Journal of Controlled Release · doi:10.1016/j.jconrel.2021.03.034 · Cited by 34 · see citing works
Li, L., Liu, S., Tan, J., Wei, L., Wu, D., Gao, S., Weng, Y., & Chen, J. (2022) · Journal of Tissue Engineering · doi:10.1177/20417314221088509 · Cited by 34 · see citing works
Chuang, S. T., Cruz, S., & Narayanaswami, V. (2020) · Nanomaterials · doi:10.3390/nano10050906 · Cited by 33 · see citing works
Bulte, J. W. M., Schmieder, A. H., Keupp, J., Caruthers, S. D., Wickline, S. A., & Lanza, G. M. (2014) · Nanomedicine Nanotechnology Biology and Medicine · doi:10.1016/j.nano.2014.05.001 · Cited by 27 · see citing works
Singh, A., Nandwana, V., Rink, J. S., Ryoo, S., Chen, T. H., Allen, S. D., Scott, E. A., Gordon, L. I., Thaxton, C. S., & Dravid, V. P. (2019) · ACS Nano · doi:10.1021/acsnano.9b03727 · Cited by 25 · see citing works
Rui, M., Xu, J., Xu, Y., Guo, Ding, Q., & Wei, X. (2012) · International Journal of Nanomedicine · doi:10.2147/ijn.s33139 · Cited by 24 · see citing works
Gupta, A., Sharma, R., Kuche, K., & Jain, S. (2021) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2021.120272 · Cited by 23 · see citing works
Modulation of Carbon Nanotubes' Perturbation to the Metabolic Activity of CYP3A4 in the Liver
Zhang, Y., Wang, Y., Liu, A., Xu, S. L., Zhao, B., Zhang, Y., Zou, H., Wang, W., Zhu, H., & Yan, B. (2015) · Advanced Functional Materials · doi:10.1002/adfm.201504182 · Cited by 22 · see citing works
Recombinant high-density lipoproteins and their use in cardiovascular diseases
Cao, Y., Xu, L., Han, Y., Wang, Y.-N., Liu, C., & Qi, R. (2016) · Drug Discovery Today · doi:10.1016/j.drudis.2016.08.010 · Cited by 19 · see citing works
Nanoengineering Apolipoprotein A1‐Based Immunotherapeutics
Schrijver, D. P., de Dreu, A., Hofstraat, S. R. J., Kluza, E., Zwolsman, R. C., Deckers, J., Anbergen, T., de Bruin, K., Trines, M. M., Nugraha, E. G., et al. (2021) · Advanced Therapeutics · doi:10.1002/adtp.202100083 · Cited by 17 · see citing works
Self-citationBanik, B., Wen, R. M., Marrache, S., Kumar, A., Kolishetti, N., Howerth, E. W., & Dhar, S. (2017) · Nanoscale · doi:10.1039/c7nr06295h · Cited by 15 · see citing works
Alanazi, S. A., Alanazi, F. K., Haq, N., Shakeel, F., Badran, M. M., & Harisa, G. I. (2020) · Current Drug Delivery · doi:10.2174/1567201817666200206104338 · Cited by 15 · see citing works
Zhang, W., Li, J., Liu, J., Wu, Z., Xu, Y., & Wang, J. (2012) · Die Pharmazie · doi:10.31083/ph.2012.1055 · Cited by 15 · see citing works
Jung, C., Heine, M., Freund, B., Reimer, R., Koziolek, E. J., Kaul, M. G., Kording, F., Schumacher, U., Weller, H., Nielsen, P., et al. (2015) · Investigative Radiology · doi:10.1097/rli.0000000000000235 · Cited by 15 · see citing works
Design of Nanovectors for Therapy and Imaging of Cardiovascular Diseases
Eniola‐Adefeso, O., Heslinga, M. J., & Porter, T. M. (2012) · Methodist DeBakey Cardiovascular Journal · doi:10.14797/mdcj-8-1-13 · Cited by 14 · see citing works
Nanophytomedicine Based Novel Therapeutic Strategies in Liver Cancer
Kumar, S., Fayaz, F., Pottoo, F. H., Bajaj, S., Manchanda, S., & Bansal, H. (2019) · Current Topics in Medicinal Chemistry · doi:10.2174/1568026619666191114113048 · Cited by 14 · see citing works
Taira, S., Kaneko, D., Onuma, K., Miyazato, A., Hiroki, T., Kawamura‐Konishi, Y., & Ichiyanagi, Y. (2012) · International Journal of Inorganic Chemistry · doi:10.1155/2012/439751 · Cited by 13 · see citing works
Russell, S., Nguyen, T. A., Bhagroo, S., Torres, C. R., Russell, M. J., & Alfano, R. R. (2014) · Journal of Biomedical Optics · doi:10.1117/1.jbo.19.1.015004 · Cited by 9 · see citing works
Im, H. (2018) · Biological and medical physics, biomedical engineering · doi:10.1007/978-3-319-67720-0_19 · Cited by 8 · see citing works
He, J., Dai, Y., Xu, F., Huang, X., Gao, Y., Liu, L., Zhang, W., & Liu, J. (2025) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2025.140826 · Cited by 7 · see citing works
Nanocrystal Core Lipoprotein Biomimetics for Imaging of Lipoproteins and Associated Diseases
Fay, F., Sánchez-Gaytán, B. L., Cormode, D. P., Skajaa, T., Fisher, E. A. A., Fayad, Z. A., & Mulder, W. J. M. (2012) · Current Cardiovascular Imaging Reports · doi:10.1007/s12410-012-9181-1 · Cited by 7 · see citing works
Self-citationImpact of Bionanointeractions of Engineered Nanoparticles for Nanomedicine
Sabella, S. (2014) · CRC Press eBooks · doi:10.1201/b16562-6 · Cited by 6 · see citing works
High-density lipoprotein is a nanoparticle, but not all nanoparticles are high-density lipoprotein
Cormode, D. P., Fisher, E. A. A., Stroes, E. S. G., Mulder, W. J. M., & Fayad, Z. A. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1310107110 · Cited by 6 · see citing works
Self-citationAdvances in contrast media for vascular imaging of atherosclerosis
Young, V. E. L., Degnan, A. J., & Gillard, J. H. (2011) · Imaging in Medicine · doi:10.2217/iim.11.23 · Cited by 5 · see citing works
Molecular Imaging with Spectral CT Nanoprobes
Pan, D., Schmieder, A. H., Senpan, A., Yang, X., Wickline, S. A., Roessl, E., Proksa, R., Schirra, C. O., & Lanza, G. M. (2016) · Springer eBooks · doi:10.1007/978-3-319-42169-8_18 · Cited by 4 · see citing works
Impact of Bionanointeractions of Engineered Nanoparticles for Nanomedicine
Sabella, S. (2014) · CRC Press eBooks · doi:10.1201/b16562-4 · Cited by 4 · see citing works
Molecular MRI of Atherosclerosis
Te, B. C., & Nicolay, K. (2012) · InTech eBooks · doi:10.5772/31550 · Cited by 1 · see citing works
Fabrication of Spheroidal Microparticles from Biodegradable Polymers for Drug Delivery Applications
Heslinga, M. J. (2012) · Cited by 1 · see citing works
Enhancement of HDL Formation and Normalization of Intravascular HDL Remodeling
Kontush, A., & Chapman, M. J. (2011) · Wiley eBooks · doi:10.1002/9781118158678.ch11
Anti-inflammatory mediators for molecular imaging of atherosclerosis
Almer, G., Opriessnig, P., Prassl, R., & Mangge, H. (2014) · European Journal of Nanomedicine · doi:10.1515/ejnm-2014-0011
Nanospheres and Applications to Cardiology
Masotti, A. (2011) · Science Publishers eBooks · doi:10.1201/b11401-11
A Synthetic Nanoparticle to Mimic High-Density Lipoprotein for Reverse Cholesterol Transport
Surnar, B., Kolishetti, N., & Dhar, S. (2025) · Methods in molecular biology · doi:10.1007/978-1-0716-4534-5_28
- Authors
- Skajaa, T., Cormode, D. P., Jarzyna, P. A., Delshad, A., Blachford, C., Barazza, A., Fisher, E. A., Gordon, R. E., Fayad, Z. A., & Mulder, W. J. M.
- Affiliations
- Aarhus University Hospital (DK)
- Icahn School of Medicine at Mount Sinai (US)
- NYU Langone Health (US)
- Mount Sinai Hospital (US)
- Corresponding author
- Fayad, Zahi A.
- Mulder, Willem J.M.
- Venue
- Biomaterials
- Publisher
- Elsevier BV
- Published
- 2011-01
- Volume
- 32
- Issue
- 1
- Pages
- 206-213
- ISSN
- 0142-9612 (ISSN-L)
- PMC
- PMC3576133
- OpenAlex
- W2089677494
- Cited by
- 69
- References
- 31
- Citations by year
- 2025: 3 · 2022: 3 · 2021: 5 · 2020: 4 · 2019: 4 · 2018: 2 · 2017: 3 · 2016: 8 · 2015: 4 · 2014: 9 · 2013: 5 · 2012: 10
- FWCI
- 3.15
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Biomaterials (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Pure Amsterdam UMC (submittedVersion)
- Funders
- National Science Foundation
- American Heart Association
- Hjerteforeningen
- National Institutes of Health
- National Heart, Lung, and Blood Institute (R01HL084312, R01HL078667, R01HL071021)
- National Cancer Institute (R24CA095823)
- National Institute of Biomedical Imaging and Bioengineering (R01EB009638, K99EB012165)
- National Center for Research Resources (1 S10RR0 9145-01)
- Topics
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Physical Sciences › Engineering › Biomedical Engineering › Characterization and Applications of Magnetic Nanoparticles
- Health Sciences › Medicine › Surgery › Cholesterol and Lipid Metabolism
- Keywords
- high-density lipoprotein, atherosclerosis, multimodal imaging, nanoparticle circulation, nanoparticle excretion, magnetic resonance imaging contrast
- MeSH terms
- Animals, Aorta, Apolipoproteins E, Biological Transport, Cell Survival, Cholesterol, Ferric Compounds, Humans, Injections, Intravenous, Kupffer Cells, Lipoproteins, HDL, Macrophages, Mice, Knockout, Microscopy, Confocal, Hepatocytes, Atherosclerosis, Mice, Nanoparticles, Hep G2 Cells
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
