Nanocrystal Core High-Density Lipoproteins: A Multimodality Contrast Agent Platform
Open accessAbstract
High density lipoprotein (HDL) is an important natural nanoparticle that may be modified for biomedical imaging purposes. Here we developed a novel technique to create unique multimodality HDL mimicking nanoparticles by incorporation of gold, iron oxide, or quantum dot nanocrystals for computed tomography, magnetic resonance, and fluorescence imaging, respectively. By including additional labels in the corona of the particles, they were made multifunctional. The characteristics of these nanoparticles, as well as their in vitro and in vivo behavior, revealed that they closely mimic native HDL.
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Follow-up studies have enabled imaging of atherosclerotic plaques using MRI, CT and optical techniques by incorporating gold nanocrystals, iron oxides or quantum dots into HDL core or contrast labels in the coating.
“Follow-up studies have provided the ability to image atherosclerotic plaques using not only MRI but also CT and optical techniques. This has been achieved by incorporating gold nanocrystals, iron oxides or quantum dots into the hydrophobic core of HDL, as well as by using contrast agent labels in the coating of the nanoparticles137.”
From Perspectives and opportunities for nanomedicine in the management of atherosclerosis (2011) · cites this paper as [137]
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Cites
Havel, R. J., Eder, H. A., & Bragdon, J. H. (1955) · Journal of Clinical Investigation · doi:10.1172/jci103182 · Cited by 8,756 · see citing works
Quantum Dots for Live Cells, in Vivo Imaging, and Diagnostics
Michalet, X., Pinaud, F. F., Bentolila, L. A., Tsay, J. M., Doose, S., Li, J. J., Sundaresan, G., Wu, A. M., Gambhir, S. S., & Weiss, S. (2005) · Science · doi:10.1126/science.1104274 · Cited by 7,794 · see citing works
Synthesis and surface engineering of iron oxide nanoparticles for biomedical applications
Gupta, A. K., & Gupta, M. S. (2004) · Biomaterials · doi:10.1016/j.biomaterials.2004.10.012 · Cited by 6,795 · see citing works
Synthesis of thiol-derivatised gold nanoparticles in a two-phase Liquid–Liquid system
Brust, M., Walker, M., Bethell, D., Schiffrin, D. J., & Whyman, R. (1994) · Journal of the Chemical Society Chemical Communications · doi:10.1039/c39940000801 · Cited by 6,714 · see citing works
Quantum dot bioconjugates for imaging, labelling and sensing
Medintz, I. L., Uyeda, H. T., Goldman, E. R., & Mattoussi, H. M. (2005) · Nature Materials · doi:10.1038/nmat1390 · Cited by 6,236 · see citing works
Lusis, A. J. (2000) · Nature · doi:10.1038/35025203 · Cited by 4,880 · see citing works
From Vulnerable Plaque to Vulnerable Patient
Naghavi, M., Libby, P., Falk, E., Casscells, S. W., Litovsky, S. H., Rumberger, J. A., Badimón, J. J., Stefanadis, C., Moreno, P., Pasterkamp, G., et al. (2003) · Circulation · doi:10.1161/01.cir.0000087481.55887.c9 · Cited by 2,686 · see citing works
Self-citationIdentification of Scavenger Receptor SR-BI as a High Density Lipoprotein Receptor
Acton, S. L., Rigotti, A., Landschulz, K. T., Xu, S., Hobbs, H. H., & Krieger, M. (1996) · Science · doi:10.1126/science.271.5248.518 · Cited by 2,347 · see citing works
From Vulnerable Plaque to Vulnerable Patient
Naghavi, M., Libby, P., Falk, E., Casscells, S. W., Litovsky, S. H., Rumberger, J. A., Badimón, J. J., Stefanadis, C., Moreno, P., Pasterkamp, G., et al. (2003) · Circulation · doi:10.1161/01.cir.0000087480.94275.97 · Cited by 2,270 · see citing works
Self-citationAmphipathic polyethyleneglycols effectively prolong the circulation time of liposomes
Klibanov, A. L., Maruyama, K., Torchilin, V. P., & Huang, L. (1990) · FEBS Letters · doi:10.1016/0014-5793(90)81016-h · Cited by 2,030 · see citing works
El‐Sayed, I. H., Huang, X., & El‐Sayed, M. A. (2005) · Nano Letters · doi:10.1021/nl050074e · Cited by 1,920 · see citing works
ApoE-deficient mice develop lesions of all phases of atherosclerosis throughout the arterial tree.
Nakashima, Y., Plump, A. S., Raines, E. W., Breslow, J. L., & Ross, R. (1994) · Arteriosclerosis and Thrombosis: A Journal of Vascular Biology · doi:10.1161/01.atv.14.1.133 · Cited by 1,693 · see citing works
Iron oxide MR contrast agents for molecular and cellular imaging
Bulte, J. W. M., & Kraitchman, D. L. (2004) · NMR in Biomedicine · doi:10.1002/nbm.924 · Cited by 1,500 · see citing works
Allen, T. M., Hansen, C., Martin, F., Redemann, C. T., & Yau‐Young, A. O. (1991) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/0005-2736(91)90246-5 · Cited by 1,392 · see citing works
Piedrahita, J. A., Zhang, S. H., Hagaman, J. R., Oliver, P. M., & Maeda, N. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.10.4471 · Cited by 944 · see citing works
Kim, D., Park, S.-J., Lee, J. H., Jeong, Y. Y., & Jon, S. (2007) · Journal of the American Chemical Society · doi:10.1021/ja071471p · Cited by 876 · see citing works
Detection of tumor angiogenesis in vivo by αvβ3-targeted magnetic resonance imaging
Sipkins, D. A., Cheresh, D. A., Kazemi, M. R., Nevin, L. M., Bednarski, M. D., & Li, K. C. (1998) · Nature Medicine · doi:10.1038/nm0598-623 · Cited by 843 · see citing works
de Vries, I. J. M., Lesterhuis, W. J., Barentsz, J. O., Verdijk, P., van Krieken, J. H., Boerman, O. C., Oyen, W. J. G., Bonenkamp, J. J., Boezeman, J. B., Adema, G. J., et al. (2005) · Nature Biotechnology · doi:10.1038/nbt1154 · Cited by 821 · see citing works
Nahrendorf, M., Jaffer, F. A., Kelly, K. A., Sosnovik, D. E., Aikawa, E., Libby, P., & Weissleder, R. (2006) · Circulation · doi:10.1161/circulationaha.106.646380 · Cited by 602 · see citing works
Lanthanides in magnetic resonance imaging
Bottrill, M., Kwok, L., & Long, N. J. (2006) · Chemical Society Reviews · doi:10.1039/b516376p · Cited by 584 · see citing works
Imaging of atherosclerotic cardiovascular disease
Sanz, J., & Fayad, Z. A. (2008) · Nature · doi:10.1038/nature06803 · Cited by 558 · see citing works
Self-citation[24] Nondenaturing polyacrylamide gradient gel electrophoresis
Nichols, A. V., Krauss, R. M., & Musliner, T. A. (1986) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/0076-6879(86)28084-2 · Cited by 522 · see citing works
Quantum Dots with a Paramagnetic Coating as a Bimodal Molecular Imaging Probe
Mulder, W. J. M., Koole, R., Brandwijk, R. J. M. G. E., Storm, G., Chin, P. T. K., Strijkers, G. J., Donegá, C. D. M., Nicolay, K., & Griffioen, A. W. (2005) · Nano Letters · doi:10.1021/nl051935m · Cited by 484 · see citing works
Self-citationHDL as a target in the treatment of atherosclerotic cardiovascular disease
Linsel‐Nitschke, P., & Tall, A. R. (2005) · Nature Reviews Drug Discovery · doi:10.1038/nrd1658 · Cited by 482 · see citing works
Noninvasive detection of macrophages using a nanoparticulate contrast agent for computed tomography
Hyafil, F., Cornily, J.-C., Feig, J. E., Gordon, R., Vucic, E., Amirbekian, V., Fisher, E. A., Fuster, V., Feldman, L. J., & Fayad, Z. A. (2007) · Nature Medicine · doi:10.1038/nm1571 · Cited by 467 · see citing works
Self-citationWinter, P. M., Caruthers, S. D., Kassner, A., Harris, T. D., Chinen, L. K., Allen, J. S., Lacy, E. K., Zhang, H., Robertson, J. D., Wickline, S. A., et al. (2003) · PubMed · Cited by 375 · see citing works
MIF: a new cytokine link between rheumatoid arthritis and atherosclerosis
Morand, E. F., Leech, M. T., & Bernhagen, J. (2006) · Nature Reviews Drug Discovery · doi:10.1038/nrd2029 · Cited by 347 · see citing works
Simultaneous Multicolor Imaging of Five Different Lymphatic Basins Using Quantum Dots
Kobayashi, H., Hama, Y., Koyama, Y., Barrett, T., Regino, C. A. S., Urano, Y., & Choyke, P. L. (2007) · Nano Letters · doi:10.1021/nl0707003 · Cited by 332 · see citing works
[32] Reconstitution of high-density lipoproteins
Jonas, A. (1986) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/0076-6879(86)28092-1 · Cited by 328 · see citing works
Virus-based nanoparticles (VNPs): Platform technologies for diagnostic imaging☆
Manchester, M., & Singh, P. K. (2006) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2006.09.014 · Cited by 292 · see citing works
In vivo magnetic resonance imaging of acute brain inflammation using microparticles of iron oxide
McAteer, M. A., Sibson, N. R., Mühlen, C. V. Z., Schneider, J. E., Lowe, A., Warrick, N., Channon, K. M., Anthony, D. C., & Choudhury, R. P. (2007) · Nature Medicine · doi:10.1038/nm1631 · Cited by 289 · see citing works
Mulder, W. J. M., Strijkers, G. J., Habets, J. W., Bleeker, E. J. W., van der Schaft, D. W. J., Storm, G., Koning, G. A., Griffioen, A. W., & Nicolay, K. (2005) · The FASEB Journal · doi:10.1096/fj.05-4145fje · Cited by 257 · see citing works
Self-citationA Liposomal System for Contrast-Enhanced Magnetic Resonance Imaging of Molecular Targets
Mulder, W. J. M., Strijkers, G. J., Griffioen, A. W., van Bloois, L., Molema, G., Storm, G., Koning, G. A., & Nicolay, K. (2004) · Bioconjugate Chemistry · doi:10.1021/bc049949r · Cited by 232 · see citing works
Self-citationMultimodal MRI contrast agents
Frullano, L., & Meade, T. J. (2007) · JBIC Journal of Biological Inorganic Chemistry · doi:10.1007/s00775-007-0265-3 · Cited by 229 · see citing works
Zheng, G., Chen, J., Li, H., & Glickson, J. D. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0508677102 · Cited by 226 · see citing works
Molecular Imaging of Cardiovascular Disease
Jaffer, F. A., Libby, P., & Weissleder, R. (2007) · Circulation · doi:10.1161/circulationaha.106.647164 · Cited by 217 · see citing works
Self-Assembled Virus-like Particles with Magnetic Cores
Huang, X., Bronstein, L. M., Retrum, J., et al. (2007) · Nano Letters · doi:10.1021/nl071083l · Cited by 172 · see citing works
Molecular magnetic resonance imaging with targeted contrast agents
Artemov, D. (2003) · Journal of Cellular Biochemistry · doi:10.1002/jcb.10660 · Cited by 168 · see citing works
Frias, J. C., Ma, Y., Williams, K. J., Fayad, Z. A., & Fisher, E. A. A. (2006) · Nano Letters · doi:10.1021/nl061498r · Cited by 164 · see citing works
Self-citationApplications of Nanotechnology to Atherosclerosis, Thrombosis, and Vascular Biology
Wickline, S. A., Neubauer, A. M., Winter, P. M., Caruthers, S. D., & Lanza, G. M. (2005) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000201069.47550.8b · Cited by 155 · see citing works
ABCA1-Induced Cell Surface Binding Sites for ApoA-I
Vedhachalam, C., Ghering, A. B., Davidson, W. S., Lund‐Katz, S., Rothblat, G. H., & Phillips, M. C. (2007) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.107.145789 · Cited by 133 · see citing works
Apolipoprotein A-I mimetic peptides and their role in atherosclerosis prevention
Navab, M., Anantharamaiah, G. M., Reddy, S. T., & Fogelman, A. M. (2006) · Nature Clinical Practice Cardiovascular Medicine · doi:10.1038/ncpcardio0661 · Cited by 131 · see citing works
Cormode, D. P., Briley-Saebo, K. C., Mulder, W. J. M., Aguinaldo, J. G. S., Barazza, A., Ma, Y., Fisher, E. A. A., & Fayad, Z. A. (2008) · Small · doi:10.1002/smll.200701285 · Cited by 107 · see citing works
Self-citationDelivery of diagnostic agents in computed tomography
Kŕause, W. (1999) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(98)00105-7 · Cited by 95 · see citing works
Organic and Inorganic Nanoparticle Hybrids
Portney, N. G., Singh, K. V., Chaudhary, S., et al. (2005) · Langmuir · doi:10.1021/la047525f · Cited by 72 · see citing works
Chronic Ethanol Increases Lipopolysaccharide-stimulated Egr-1 Expression in RAW 264.7 Macrophages
Shi, L., Kishore, R., McMullen, M. R., & Nagy, L. E. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m108967200 · Cited by 68 · see citing works
Targeted imaging of human endothelial-specific marker in a model of adoptive cell transfer
Kang, H. W., Torres, D. M., Wald, L. L., et al. (2006) · Laboratory Investigation · doi:10.1038/labinvest.3700421 · Cited by 67 · see citing works
Integrated Magnetic Bionanocomposites through Nanoparticle-Mediated Assembly of Ferritin
Srivastava, S., Samanta, B., Jordan, B. J., et al. (2007) · Journal of the American Chemical Society · doi:10.1021/ja073163x · Cited by 59 · see citing works
Multimodality nanotracers for cardiovascular applications
Mulder, W. J. M., Cormode, D. P., Hak, S., Lobatto, M. E., Silvera, S., & Fayad, Z. A. (2008) · Nature Clinical Practice Cardiovascular Medicine · doi:10.1038/ncpcardio1242 · Cited by 53 · see citing works
Self-citationThe Role of Macrophages in Tumor Development
van der Bij, G. J., Oosterling, S. J., Meijer, S., Beelen, R. H. J., & van Egmond, M. (2005) · Analytical Cellular Pathology · doi:10.1155/2005/719412 · Cited by 37 · see citing works
Kim, D. K., Park, S.-J., Lee, J. H., et al. (2007) · Journal of the American Chemical Society · doi:10.1021/ja076341v · Cited by 17 · see citing works
Modified Lipoproteins As Contrast Agents For Molecular Imaging
Cormode, D. P., Mulder, W. J. M., Fisher, E. A. A., & Fayad, Z. A. (2007) · Future Lipidology · doi:10.2217/17460875.2.6.587 · Cited by 4 · see citing works
Self-citation
Flagged first, then by citations
Research works printed but not linked: 4
- [3]El-Sayed IH Huang X El-Sayed MA Nano Lett 2005 5 829 834 15884879
- [14]Linsel-Nitschke P Tall AR Nat Rev Drug Discov 2005 4 193 205 15738977
- [35]Kim D Park S Lee JH Jeong YY Jon S J Am Chem Soc 2007 129 12585 12585 17530850
- [48]Winter PM Caruthers SD Kassner A Harris TD Chinen LK Allen JS Lacy EK Zhang H Robertson JD Wickline SA Lanza GM Cancer Res 2003 63 5838 5843 14522907
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Thaxton, C. S., Daniel, W. L., Giljohann, D. A., Thomas, A. D., & Mirkin, C. A. (2009) · Journal of the American Chemical Society · doi:10.1021/ja808856z · Cited by 122 · see citing works
Skajaa, T., Zhao, Y., van den Heuvel, D. J., Gerritsen, H. C., Cormode, D. P., Koole, R., van Schooneveld, M. M., Post, J. A., Fisher, E. A., Fayad, Z. A., et al. (2010) · Nano Letters · doi:10.1021/nl1037903 · Cited by 76 · see citing works
Self-citationCormode, D. P., Chandrasekar, R., Delshad, A., Briley-Saebo, K. C., Calcagno, C., Barazza, A., Mulder, W. J. M., Fisher, E. A., & Fayad, Z. A. (2009) · Bioconjugate Chemistry · doi:10.1021/bc800520d · Cited by 72 · see citing works
Self-citationSkajaa, T., Cormode, D. P., Jarzyna, P. A., Delshad, A., Blachford, C., Barazza, A., Fisher, E. A., Gordon, R. E., Fayad, Z. A., & Mulder, W. J. M. (2011) · Biomaterials · doi:10.1016/j.biomaterials.2010.08.078 · Cited by 69 · see citing works
Self-citationBuxton, D. B., Antman, M., Danthi, N., Dilsizian, V., Fayad, Z. A., Garcia, M. J., Jaff, M. R., Klimas, M., Libby, P., Nahrendorf, M., et al. (2011) · Circulation · doi:10.1161/circulationaha.110.000943 · Cited by 49 · see citing works
Self-citation
- Authors
- Cormode, D. P., Skajaa, T., van Schooneveld, M. M., Koole, R., Jarzyna, P., Lobatto, M. E., Calcagno, C., Barazza, A., Gordon, R. E., Zanzonico, P., Fisher, E. A., Fayad, Z. A., & Mulder, W. J. M.
- Affiliations
- Mount Sinai Hospital (US)
- Translational and Molecular Imaging Institute, Mount Sinai School of Medicine, One Gustave L. Levy Place, Box 1234, New York, New York 10029, Faculty of Health Sciences, Århus University, Vennelyst Boulevard 9, 8000 Århus C, Denmark, Condensed Matter and Interfaces, Debye Institute, Utrecht University, Princetonplein 5, 3584 CC Utrecht, The Netherlands, Department of Medicine (Cardiology), Marc and Ruti Bell Vascular Biology and Disease Program and the NYU Center for the Prevention of Cardiovascular...
- Corresponding author
- Fayad, Zahi A.
- Mulder, Willem J. M.
- ORCID
- Venue
- Nano Letters
- Publisher
- American Chemical Society (ACS)
- Published
- 2008-10-22
- Volume
- 8
- Issue
- 11
- Pages
- 3715-3723
- ISSN
- 1530-6984 (ISSN-L)
- 1530-6992
- PMC
- PMC2629801
- OpenAlex
- W1998993589
- Cited by
- 328
- References
- 52
- Citations by year
- 2025: 3 · 2024: 12 · 2023: 9 · 2022: 12 · 2021: 16 · 2020: 17 · 2019: 15 · 2018: 16 · 2017: 17 · 2016: 21 · 2015: 23 · 2014: 31 · 2013: 31 · 2012: 22
- FWCI
- 11.63
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Nano Letters (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Pure Amsterdam UMC (submittedVersion)
- Funders
- National Heart, Lung, and Blood Institute (R01 HL 71021, R01HL078667, R01HL071021, R01 HL 78667)
- National Cancer Institute (P30-CA-08748, R24CA83084, R24CA095823, R24CA083084, P30CA008748)
- National Center for Research Resources (1 S10RR0 9145-01)
- Topics
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Physical Sciences › Materials Science › Materials Chemistry › Quantum Dots Synthesis And Properties
- Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
- Keywords
- high-density lipoprotein, gold nanocrystals, iron oxide nanoparticles, quantum dots, computed tomography contrast, magnetic resonance imaging contrast, fluorescence imaging, nanoparticle corona, in vivo biodistribution
- MeSH terms
- Animals, Cell Line, Contrast Media, Gold, Lipoproteins, HDL, Macrophages, Microscopy, Electron, Transmission, Mice, Metal Nanoparticles
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