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Enzyme-Instructed Molecular Self-assembly Confers Nanofibers and a Supramolecular Hydrogel of Taxol Derivative
Abstract
By covalently connecting taxol with a motif that is prone to self-assemble, we successfully generate the precursor (5a), the hydrogelator (5b), and hydrogel of a taxol derivative without compromising the cytotoxic activity of the taxol. This approach promises a general method to create nanofibers of therapeutic molecules that have a dual role, as both the delivery vehicle and the drug itself.
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Metadata
- Authors
- Gao, Y., Kuang, Y., Guo, Z.-F., Guo, Z., Krauss, I. J., & Xu, B.
- Venue
- Journal of the American Chemical Society
- Publisher
- American Chemical Society (ACS)
- Published
- 2009-09-04
- Volume
- 131
- Issue
- 38
- Pages
- 13576-13577
- ISSN
- 0002-7863 (ISSN-L)
- 1520-5126
- OpenAlex
- W2013298034
- Cited by
- 403
- References
- 26
- FWCI
- 8.07
- Type
- journal article
- Language
- en
- Open access
- closed
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