The DOI matches its Crossref record; 19 of the 19 references it cites were found in a registry or an index.
DNA-Mediated Charge Transport in Redox Sensing and Signaling
Open accessAbstract
The transport of charge through the DNA base-pair stack offers a route to carry out redox chemistry at a distance. Here we describe characteristics of this chemistry that have been elucidated and how this chemistry may be utilized within the cell. The shallow distance dependence associated with these redox reactions permits DNA-mediated signaling over long molecular distances in the genome and facilitates the activation of redox-sensitive transcription factors globally in response to oxidative stress. The long-range funneling of oxidative damage to sites of low oxidation potential in the genome also may provide a means of protection within the cell. Furthermore, the sensitivity of DNA charge transport to perturbations in base-pair stacking, as may arise with base lesions and mismatches, may be used as a route to scan the genome for damage as a first step in DNA repair. Thus, the ability of double-helical DNA in mediating redox chemistry at a distance provides a natural mechanism for redox sensing and signaling in the genome.
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Metadata
- Authors
- Genereux, J. C., Boal, A. K., & Barton, J. K.
- Venue
- Journal of the American Chemical Society
- Publisher
- American Chemical Society (ACS)
- Published
- 2010-01-04
- Volume
- 132
- Issue
- 3
- Pages
- 891-905
- ISSN
- 0002-7863 (ISSN-L)
- 1520-5126
- OpenAlex
- W2146549847
- Cited by
- 173
- References
- 19
- FWCI
- 9.33
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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