The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Direct Detection of Nitroxyl in Aqueous Solution Using a Tripodal Copper(II) BODIPY Complex
Open accessAbstract
The synthesis, photophysical properties, and a biological application of BODIPY-triazole 1 (BOT1) are described. BOT1 juxtaposes a BODIPY fluorophore with a tripodal ligand platform via a triazole bridge. The triazole linker is afforded by azide-alkyne "click" chemistry and comprises the third arm of the tripodal architecture. BOT1 binds Cu(2+) in aqueous solution to form a Cu(II)[BOT1] complex in which emission from the BODIPY moiety is efficiently quenched. This complex exhibits a prompt turn-on response when exposed to nitroxyl, and this emission response is specific to HNO over other reactive nitrogen and oxygen species. Notably, Cu(II)[BOT1] does not fluoresce in the presence of nitric oxide, making this system the first discrete molecular probe capable of detecting HNO over NO under physiologically relevant conditions. Fluorescence microscopy experiments establish that Cu(II)[BOT1] is membrane-permeable and can successfully signal the presence of HNO in live cells.
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Nitric oxide: physiology, pathophysiology, and pharmacology.
Moncada, S., Palmer, R. M., & Higgs, E. A. (1991) · Pharmacological Reviews · doi:10.1016/s0031-6997(25)06663-3 · Cited by 15,525
BODIPY Dyes and Their Derivatives: Syntheses and Spectroscopic Properties
Loudet, A., & Burgess, K. (2007) · Chemical Reviews · doi:10.1021/cr078381n · Cited by 5,238
Miranda, K. M., Paolocci, N., Katori, T., Thomas, D. D., Ford, E., Bartberger, M. D., Espey, M. G., Kass, D. A., Feelisch, M., Fukuto, J. M., et al. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1430507100 · Cited by 283
Nitroxyl (HNO): the Cinderella of the nitric oxide story
Irvine, J. C., Ritchie, R. H., Favaloro, J. L., Andrews, K. L., Widdop, R. E., & Kemp-Harper, B. K. (2008) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2008.08.005 · Cited by 277
Cited by
Metal coordination in photoluminescent sensing
Liu, Z., He, W., & Guo, Z. (2013) · Chemical Society Reviews · doi:10.1039/c2cs35363f · Cited by 800
Eberhardt, M., Dux, M., Namer, B., Miljkovic, J., Cordasic, N., Will, C., Kichko, T. I., de la Roche, J., Fischer, M., Suárez, S. A., et al. (2014) · Nature Communications · doi:10.1038/ncomms5381 · Cited by 379
Filipovic, M. R., Miljkovic, J. L., Nauser, T., Royzen, M., Klos, K., Shubina, T., Koppenol, W. H., Lippard, S. J., & Ivanović-Burmazović, I. (2012) · Journal of the American Chemical Society · doi:10.1021/ja3009693 · Cited by 336
Generation of HNO and HSNO from Nitrite by Heme‐Iron‐Catalyzed Metabolism with H2S
Miljkovic, J. L., Kenkel, I., Ivanović‐Burmazović, I., & Filipovic, M. R. (2013) · Angewandte Chemie International Edition · doi:10.1002/anie.201305669 · Cited by 148
Potential biological chemistry of hydrogen sulfide (H2S) with the nitrogen oxides
Bruce King, S. (2013) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2012.11.005 · Cited by 103
Metadata
- Authors
- Rosenthal, J., & Lippard, S. J.
- Venue
- Journal of the American Chemical Society
- Publisher
- American Chemical Society (ACS)
- Published
- 2010-03-31
- Volume
- 132
- Issue
- 16
- Pages
- 5536-5537
- ISSN
- 0002-7863 (ISSN-L)
- 1520-5126
- OpenAlex
- W2122282115
- Cited by
- 265
- References
- 4
- FWCI
- 11.19
- Type
- journal article
- Language
- en
- Open access
- green
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