The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Design of a Functionalized Metal–Organic Framework System for Enhanced Targeted Delivery to Mitochondria
Open accessAbstract
Abstract Mitochondria play a key role in oncogenesis and constitute one of the most important targets for cancer treatments. Although the most effective way to deliver drugs to mitochondria is by covalently linking them to a lipophilic cation, the in vivo delivery of free drugs still constitutes a critical bottleneck. Herein, we report the design of a mitochondria-targeted metal–organic framework (MOF) that greatly increases the efficacy of a model cancer drug, reducing the required dose to less than 1% compared to the free drug and ca. 10% compared to the nontargeted MOF. The performance of the system is evaluated using a holistic approach ranging from microscopy to transcriptomics. Super-resolution microscopy of MCF-7 cells treated with the targeted MOF system reveals important mitochondrial morphology changes that are clearly associated with cell death as soon as 30 min after incubation. Whole transcriptome analysis of cells indicates widespread changes in gene expression when treated with the MOF system, specifically in biological processes that have a profound effect on cell physiology and that are related to cell death. We show how targeting MOFs toward mitochondria represents a valuable strategy for the development of new drug delivery systems.
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Cites
Tumor cell metabolism: cancer's Achilles' heel
Kroemer, G., & Pouyssegur, J. (2008) · Cancer Cell · doi:10.1016/j.ccr.2008.05.005 · Cited by 2,337
Zielonka, J., Joseph, J., Sikora, A., Hardy, M., Ouari, O., Vasquez-Vivar, J., Cheng, G., Lopez, M., & Kalyanaraman, B. (2017) · Chemical Reviews · doi:10.1021/acs.chemrev.7b00042 · Cited by 1,683
He, C., Lu, K., Liu, D., & Lin, W. (2014) · Journal of the American Chemical Society · doi:10.1021/ja4098862 · Cited by 885
Cited by
Metal–Organic Frameworks for Drug Delivery: A Design Perspective
Lawson, H. D., Walton, S. P., & Chan, C. (2021) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.1c01089 · Cited by 916
Metal-organic frameworks for advanced drug delivery
He, S., Wu, L., Li, X., Sun, H., Xiong, T., Liu, J., Huang, C., Xu, H., Sun, H., Chen, W., et al. (2021) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2021.03.019 · Cited by 528
Multifunctional metal–organic framework heterostructures for enhanced cancer therapy
Liu, J., Huang, J., Zhang, L., & Lei, J. (2021) · Chemical Society Reviews · doi:10.1039/d0cs00178c · Cited by 285
Nanoscale Mixed-Ligand Metal–Organic Framework for X-ray Stimulated Cancer Therapy
Zhen, W., Xu, Z., Mao, Y., McCleary, C., Jiang, X., Weichselbaum, R. R., & Lin, W. (2024) · Journal of the American Chemical Society · doi:10.1021/jacs.4c12140 · Cited by 37
Metadata
- Authors
- Haddad, S., Abánades Lázaro, I., Fantham, M., Mishra, A., Silvestre-Albero, J., Osterrieth, J. W. M., Kaminski Schierle, G. S., Kaminski, C. F., Forgan, R. S., & Fairen-Jimenez, D.
- Venue
- Journal of the American Chemical Society
- Publisher
- American Chemical Society (ACS)
- Published
- 2020-03-17
- Volume
- 142
- Issue
- 14
- Pages
- 6661-6674
- ISSN
- 0002-7863 (ISSN-L)
- 1520-5126
- OpenAlex
- W3011953046
- Cited by
- 161
- References
- 3
- FWCI
- 14.09
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Haddad, S., Abánades Lázaro, I., Fantham, M., Mishra, A., Silvestre-Albero, J., Osterrieth, J. W. M., Kaminski Schierle, G. S., Kaminski, C. F., Forgan, R. S., & Fairen-Jimenez, D. (2020). Design of a Functionalized Metal–Organic Framework System for Enhanced Targeted Delivery to Mitochondria. Journal of the American Chemical Society. https://doi.org/10.1021/jacs.0c00188
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