The DOI matches its Crossref record; 46 of the 46 references it cites were found in a registry or an index.
Silica Nanopollens Enhance Adhesion for Long-Term Bacterial Inhibition
Abstract
Nature's creations with spiky topological features typically exhibit intriguing surface adhesive properties. From micrometer-sized pollen grains that can easily stick to hairy insects for pollination to nanoscale virus particles that are highly infectious toward host cells, multivalent interactions are formed taking advantage of rough surfaces. Herein, this nature-inspired concept is employed to develop novel drug delivery nanocarriers for antimicrobial applications. A facile new approach is developed to fabricate silica nanopollens (mesoporous silica nanospheres with rough surfaces), which show enhanced adhesion toward bacteria surfaces compared to their counterparts with smooth surfaces. Lysozyme, a natural antimicrobial enzyme, is loaded into silica nanopollens and shows sustained release behavior, potent antimicrobial activity, and long-term total bacterial inhibition up to 3 days toward Escherichia coli. The potent antibacterial activity of lysozyme-loaded silica nanopollens is further demonstrated ex vivo by using a small-intestine infection model. Our strategy provides a novel pathway in the rational design of nanocarriers for efficient drug delivery.
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Self-citationCroissant, J. G., Fatieiev, Y., Almalik, A., & Khashab, N. M. (2018) · Advanced Healthcare Materials · doi:10.1002/adhm.201700831 · Cited by 594
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Zhao, N., Yan, L., Zhao, X., Chen, X., Li, A., Zheng, D., Zhou, X., Dai, X., & Xu, F.-J. (2019) · Chemical Reviews · doi:10.1021/acs.chemrev.8b00401 · Cited by 429
Defect‐Rich Adhesive Nanozymes as Efficient Antibiotics for Enhanced Bacterial Inhibition
Cao, F., Zhang, L., Wang, H., You, Y., Wang, Y., Gao, N., Ren, J., & Qu, X. (2019) · Angewandte Chemie International Edition · doi:10.1002/anie.201908289 · Cited by 346
Metadata
- Authors
- Song, H., Ahmad Nor, Y., Yu, M., Yang, Y., Zhang, J., Zhang, H., Xu, C., Mitter, N., & Yu, C.
- Venue
- Journal of the American Chemical Society
- Publisher
- American Chemical Society (ACS)
- Published
- 2016-05-13
- Volume
- 138
- Issue
- 20
- Pages
- 6455-6462
- ISSN
- 0002-7863 (ISSN-L)
- 1520-5126
- OpenAlex
- W2346431966
- Cited by
- 286
- References
- 46
- FWCI
- 9.15
- Type
- journal article
- Language
- en
- Open access
- closed
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- Song, H., Ahmad Nor, Y., Yu, M., Yang, Y., Zhang, J., Zhang, H., Xu, C., Mitter, N., & Yu, C. (2016). Silica Nanopollens Enhance Adhesion for Long-Term Bacterial Inhibition. Journal of the American Chemical Society. https://doi.org/10.1021/jacs.6b00243
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