The DOI matches its Crossref record; 51 of the 51 references it cites were found in a registry or an index.
Defect‐Rich Adhesive Nanozymes as Efficient Antibiotics for Enhanced Bacterial Inhibition
Abstract
Nanozymes have emerged as a new generation of antibiotics with exciting broad‐spectrum antimicrobial properties and negligible biotoxicities. However, their antibacterial efficacies are unsatisfactory due to their inability to trap bacteria and their low catalytic activity. Herein, we report nanozymes with rough surfaces and defect‐rich active edges. The rough surface increases bacterial adhesion and the defect‐rich edges exhibit higher intrinsic peroxidase‐like activity compared to pristine nanozymes due to their lower adsorption energies of H 2 O 2 and desorption energy of OH*, as well as the larger exothermic process for the whole reaction. This was demonstrated using drug‐resistant Gram‐negative Escherichia coli and Gram‐positive Staphylococcus aureus in vitro and in vivo. This strategy can be used to engineer nanozymes with enhanced antibacterial function and will pave a new way for the development of alternative antibiotics.
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Cited by
Metal–Organic-Framework-Based Materials for Antimicrobial Applications
Li, R., Chen, T., & Pan, X. (2021) · ACS Nano · doi:10.1021/acsnano.0c09617 · Cited by 555
An overview of the use of nanozymes in antibacterial applications
Mei, L., Zhu, S., Liu, Y., Yin, W., Gu, Z., & Zhao, Y. (2021) · Chemical Engineering Journal · doi:10.1016/j.cej.2021.129431 · Cited by 369
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Recent advances of cancer chemodynamic therapy based on Fenton/Fenton-like chemistry
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Ultrasmall Fe-doped carbon dots nanozymes for photoenhanced antibacterial therapy and wound healing
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Metadata
- Authors
- Cao, F., Zhang, L., Wang, H., You, Y., Wang, Y., Gao, N., Ren, J., & Qu, X.
- Venue
- Angewandte Chemie International Edition
- Publisher
- Wiley
- Published
- 2019-09-26
- Volume
- 58
- Issue
- 45
- Pages
- 16236-16242
- ISSN
- 1433-7851 (ISSN-L)
- 1521-3773
- OpenAlex
- W2970562511
- Cited by
- 346
- References
- 51
- FWCI
- 14.07
- Type
- journal article
- Language
- en
- Open access
- closed
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- Cao, F., Zhang, L., Wang, H., You, Y., Wang, Y., Gao, N., Ren, J., & Qu, X. (2019). Defect‐Rich Adhesive Nanozymes as Efficient Antibiotics for Enhanced Bacterial Inhibition. Angewandte Chemie International Edition. https://doi.org/10.1002/anie.201908289
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