The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Semiconducting Polymer Nanobioconjugates for Targeted Photothermal Activation of Neurons
Open accessAbstract
Optogenetics provides powerful means for precise control of neuronal activity; however, the requirement of transgenesis and the incapability to extend the neuron excitation window into the deep-tissue-penetrating near-infrared (NIR) region partially limit its application. We herein report a potential alternative approach to optogenetics using semiconducting polymer nanobioconjugates (SPNsbc) as the photothermal nanomodulator to control the thermosensitive ion channels in neurons. SPNsbc are designed to efficiently absorb the NIR light at 808 nm and have a photothermal conversion efficiency higher than that of gold nanorods. By virtue of the fast heating capability in conjunction with the precise targeting to the thermosensitive ion channel, SPNsbc can specifically and rapidly activate the intracellular Ca(2+) influx of neuronal cells in a reversible and safe manner. Our study provides an organic nanoparticle based strategy that eliminates the need for genetic transfection to remotely regulate cellular machinery.
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The development and application of optogenetics
Fenno, L., Yizhar, O., & Deisseroth, K. (2011) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-061010-113817 · Cited by 1,822
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Ultralong Phosphorescence of Water‐Soluble Organic Nanoparticles for In Vivo Afterglow Imaging
Zhen, X., Tao, Y., An, Z., Chen, P., Xu, C., Chen, R., Huang, W., & Pu, K. (2017) · Advanced Materials · doi:10.1002/adma.201606665 · Cited by 602
Self-citationJiang, Y., Li, J., Zhen, X., Xie, C., & Pu, K. (2018) · Advanced Materials · doi:10.1002/adma.201705980 · Cited by 601
Self-citationDonor Engineering for NIR-II Molecular Fluorophores with Enhanced Fluorescent Performance
Yang, Q., Hu, Z., Zhu, S., Ma, R., Ma, H., Ma, Z., Wan, H., Zhu, T., Jiang, Z., Liu, W., et al. (2018) · Journal of the American Chemical Society · doi:10.1021/jacs.7b10334 · Cited by 554
Recent Advances in Cell Membrane–Camouflaged Nanoparticles for Cancer Phototherapy
Zhen, X., Cheng, P., & Pu, K. (2019) · Small · doi:10.1002/smll.201804105 · Cited by 483
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Metadata
- Authors
- Lyu, Y., Xie, C., Chechetka, S. A., Miyako, E., & Pu, K.
- Venue
- Journal of the American Chemical Society
- Publisher
- American Chemical Society (ACS)
- Published
- 2016-07-14
- Volume
- 138
- Issue
- 29
- Pages
- 9049-9052
- ISSN
- 0002-7863 (ISSN-L)
- 1520-5126
- OpenAlex
- W2468620463
- Cited by
- 460
- References
- 1
- FWCI
- 31.01
- Type
- journal article
- Language
- en
- Open access
- green
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- Lyu, Y., Xie, C., Chechetka, S. A., Miyako, E., & Pu, K. (2016). Semiconducting Polymer Nanobioconjugates for Targeted Photothermal Activation of Neurons. Journal of the American Chemical Society. https://doi.org/10.1021/jacs.6b05192
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