The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Ultralow-Power Near Infrared Lamp Light Operable Targeted Organic Nanoparticle Photodynamic Therapy
Abstract
Tissue penetration depth is a major challenge in practical photodynamic therapy (PDT). A biocompatible and highly effective near infrared (NIR)-light-absorbing carbazole-substituted BODIPY ( Car-BDP ) molecule is reported as a class of imaging-guidable deep-tissue activatable photosensitizers for PDT. Car-BDP possesses an intense, broad NIR absorption band (600–800 nm) with a remarkably high singlet oxygen quantum yield (Φ Δ = 67%). After being encapsulated with biodegradable PLA–PEG-FA polymers, Car-BDP can form uniform and small organic nanoparticles that are water-soluble and tumor-targetable. Rather than using laser light, such nanoparticles offer an unprecedented deep-tissue, tumor targeting photodynamic therapeutic effect by using an exceptionally low-power-density and cost-effective lamp light (12 mW cm –2 ). In addition, these nanoparticles can be simultaneously traced in vivo due to their excellent NIR fluorescence. This study signals a major step forward in photodynamic therapy by developing a new class of NIR-absorbing biocompatible organic nanoparticles for effective targeting and treatment of deep-tissue tumors. This work also provides a potential new platform for precise tumor-targeting theranostics and novel opportunities for future affordable clinical cancer treatment.
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Citations
Cites
BODIPY Dyes and Their Derivatives: Syntheses and Spectroscopic Properties
Loudet, A., & Burgess, K. (2007) · Chemical Reviews · doi:10.1021/cr078381n · Cited by 5,238
BODIPY dyes in photodynamic therapy
Kamkaew, A., Lim, S. H., Lee, H. B., Kiew, L. V., Chung, L. Y., & Burgess, K. (2013) · Chem. Soc. Rev. · doi:10.1039/c2cs35216h · Cited by 2,104
Cited by
Photosensitizers for Photodynamic Therapy
Lan, M., Zhao, S., Liu, W., Lee, C., Zhang, W., & Wang, P. (2019) · Advanced Healthcare Materials · doi:10.1002/adhm.201900132 · Cited by 1,081
Ma, P., Xiao, H., Yu, C., Liu, J., Cheng, Z., Song, H., Zhang, X., Li, C., Wang, J., Gu, Z., et al. (2017) · Nano Letters · doi:10.1021/acs.nanolett.6b04269 · Cited by 649
Gao, G., Jiang, Y.-W., Jia, H.-R., & Wu, F.-G. (2019) · Biomaterials · doi:10.1016/j.biomaterials.2018.09.045 · Cited by 485
Zhou, Y., Fan, S., Feng, L., Huang, X., & Chen, X. (2021) · Advanced Materials · doi:10.1002/adma.202104223 · Cited by 463
Wu, W., Mao, D., Hu, F., Xu, S., Chen, C., Zhang, C., Cheng, X., Yuan, Y., Ding, D., Kong, D., et al. (2017) · Advanced Materials · doi:10.1002/adma.201700548 · Cited by 462
Metadata
- Authors
- Huang, L., Li, Z., Zhao, Y., Zhang, Y., Wu, S., Zhao, J., & Han, G.
- Venue
- Journal of the American Chemical Society
- Publisher
- American Chemical Society (ACS)
- Published
- 2016-10-27
- Volume
- 138
- Issue
- 44
- Pages
- 14586-14591
- ISSN
- 0002-7863 (ISSN-L)
- 1520-5126
- OpenAlex
- W2543764929
- Cited by
- 301
- References
- 2
- FWCI
- 32.57
- Type
- journal article
- Language
- en
- Open access
- closed
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- Huang, L., Li, Z., Zhao, Y., Zhang, Y., Wu, S., Zhao, J., & Han, G. (2016). Ultralow-Power Near Infrared Lamp Light Operable Targeted Organic Nanoparticle Photodynamic Therapy. Journal of the American Chemical Society. https://doi.org/10.1021/jacs.6b05390
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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