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Mitochondria Targeted Protein-Ruthenium Photosensitizer for Efficient Photodynamic Applications
Open accessAbstract
Organelle-targeted photosensitization represents a promising approach in photodynamic therapy where the design of the active photosensitizer (PS) is very crucial. In this work, we developed a macromolecular PS with multiple copies of mitochondria-targeting groups and ruthenium complexes that displays highest phototoxicity toward several cancerous cell lines. In particular, enhanced anticancer activity was demonstrated in acute myeloid leukemia cell lines, where significant impairment of proliferation and clonogenicity occurs. Finally, attractive two-photon absorbing properties further underlined the great significance of this PS for mitochondria targeted PDT applications in deep tissue cancer therapy.
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Cited by
Recent Strategies to Develop Innovative Photosensitizers for Enhanced Photodynamic Therapy
Pham, T. C., Nguyen, V.-N., Choi, Y., Lee, S., & Yoon, J. (2021) · Chemical Reviews · doi:10.1021/acs.chemrev.1c00381 · Cited by 1,813
Supramolecular cancer nanotheranostics
Zhou, J., Rao, L., Yu, G., Cook, T. R., Chen, X., & Huang, F. (2021) · Chemical Society Reviews · doi:10.1039/d0cs00011f · Cited by 411
Zheng, Z., Zhang, T., Liu, H., Chen, Y., Kwok, R. T. K., Ma, C., Zhang, P., Sung, H. H. Y., Williams, I. D., Lam, J. W. Y., et al. (2018) · ACS Nano · doi:10.1021/acsnano.8b03138 · Cited by 340
Lee, L. C.-C., & Lo, K. K.-W. (2022) · Journal of the American Chemical Society · doi:10.1021/jacs.2c03437 · Cited by 279
Zheng, Z., Liu, H., Zhai, S., Zhang, H., Shan, G., Kwok, R. T. K., Ma, C., Sung, H. H. Y., Williams, I. D., Lam, J. W. Y., et al. (2020) · Chemical Science · doi:10.1039/c9sc06441a · Cited by 172
Metadata
- Authors
- Chakrabortty, S., Agrawalla, B. K., Stumper, A., Vegi, N. M., Fischer, S., Reichardt, C., Kögler, M., Dietzek, B., Feuring-Buske, M., Buske, C., Rau, S., & Weil, T.
- Venue
- Journal of the American Chemical Society
- Publisher
- American Chemical Society (ACS)
- Published
- 2017-02-07
- Volume
- 139
- Issue
- 6
- Pages
- 2512-2519
- ISSN
- 0002-7863 (ISSN-L)
- 1520-5126
- OpenAlex
- W2578281794
- Cited by
- 317
- References
- 0
- FWCI
- 31.79
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Chakrabortty, S., Agrawalla, B. K., Stumper, A., Vegi, N. M., Fischer, S., Reichardt, C., Kögler, M., Dietzek, B., Feuring-Buske, M., Buske, C., Rau, S., & Weil, T. (2017). Mitochondria Targeted Protein-Ruthenium Photosensitizer for Efficient Photodynamic Applications. Journal of the American Chemical Society. https://doi.org/10.1021/jacs.6b13399
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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