Bright Near-Infrared Aggregation-Induced Emission Luminogens with Strong Two-Photon Absorption, Excellent Organelle Specificity, and Efficient Photodynamic Therapy Potential

Zheng, Zheng; Zhang, Tianfu; Liu, Haixiang; Chen, Yuncong; Kwok, Ryan T. K.; Ma, Chao; Zhang, Pengfei; Sung, Herman H. Y.; Williams, Ian D.; Lam, Jacky W. Y.; Wong, Kam Sing; Tang, Ben Zhong

doi:10.1021/acsnano.8b03138

Cited by 340Luminescence and Fluorescent MaterialsMolecular Sensors and Ion DetectionNonlinear Optical Materials Studies

Bright Near-Infrared Aggregation-Induced Emission Luminogens with Strong Two-Photon Absorption, Excellent Organelle Specificity, and Efficient Photodynamic Therapy Potential

Zheng, Zheng, Zhang, Tianfu, Liu, Haixiang, Chen, Yuncong, Kwok, Ryan T. K., Ma, Chao, Zhang, Pengfei, Sung, Herman H. Y. +4 more·2018·ACS Nano

DOI 10.1021/acsnano.8b03138

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Abstract

Far-red and near-infrared (NIR) fluorescent materials possessing the characteristics of strong two-photon absorption and aggregation-induced emission (AIE) as well as specific targeting capability are much-sought-after for bioimaging and therapeutic applications due to their deep penetration depth and high resolution. Herein, a series of dipolar far-red and NIR AIE luminogens with a strong push-pull effect are designed and synthesized. The obtained fluorophores display bright far-red and NIR solid-state fluorescence with a high quantum yield of up to 30%, large Stokes shifts of up to 244 nm, and large two-photon absorption cross-sections of up to 887 GM. A total of three neutral AIEgens show specific lipid droplet (LD)-targeting capability, while the one with cationic and lipophilic characteristics tends to target the mitochondria specifically. All of the molecules demonstrate good biocompatibility, high brightness, and superior photostability. They also serve as efficient two-photon fluorescence-imaging agents for the clear visualization of LDs or mitochondria in living cells and tissues with deep tissue penetration (up to 150 μm) and high contrast. These AIEgens can efficiently generate singlet oxygen upon light irradiation for the photodynamic ablation of cancer cells. All of these intriguing results prove that these far-red and NIR AIEgens are excellent candidates for the two-photon fluorescence imaging of LDs or mitochondria and organelle-targeting photodynamic cancer therapy.

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Photosensitizers for Photodynamic Therapy
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Design of superior phototheranostic agents guided by Jablonski diagrams
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Antibiotic‐Free Antibacterial Strategies Enabled by Nanomaterials: Progress and Perspectives
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Small molecule based fluorescent chemosensors for imaging the microenvironment within specific cellular regions
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Mito‐Bomb: Targeting Mitochondria for Cancer Therapy
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Aggregation-Induced Emission (AIE), Life and Health
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The fast-growing field of photo-driven theranostics based on aggregation-induced emission
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Aggregation-Induced Emission: A Trailblazing Journey to the Field of Biomedicine
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Recent Advances in Fluorescent Probes for Lipid Droplets
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“While developed AIE-based bioprobes demonstrated their utility to stain LDs, they usually displayed blue-shifted emission in LDs in comparison to the emission in water, except for TPE-AC, DCMa, DCIs, and DCFu which preserved its NIR fluorescence [53,55].”
BackgroundInfluential
Gathering brings strength: How organic aggregates boost disease phototheranostics
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Strategies to Enhance the Photosensitization: Polymerization and the Donor–Acceptor Even–Odd Effect
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Designing bioresponsive nanomaterials for intracellular self-assembly
Chagri, S., Ng, D. Y. W., & Weil, T. (2022) · Nature Reviews Chemistry · doi:10.1038/s41570-022-00373-x · Cited by 265 · see citing works
Tuning Organelle Specificity and Photodynamic Therapy Efficiency by Molecular Function Design
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An NIR‐II‐Emissive Photosensitizer for Hypoxia‐Tolerant Photodynamic Theranostics
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In Situ Monitoring Apoptosis Process by a Self-Reporting Photosensitizer
Zhang, T., Li, Y., Zheng, Z., Ye, R., Zhang, Y., Kwok, R. T. K., Lam, J. W. Y., & Tang, B. Z. (2019) · Journal of the American Chemical Society · doi:10.1021/jacs.9b00636 · Cited by 236 · see citing works
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AIE luminogens as fluorescent bioprobes
Niu, G., Zhang, R., Shi, X., Park, H., Xie, S., Kwok, R. T. K., Lam, J. W. Y., & Tang, B. Z. (2019) · TrAC Trends in Analytical Chemistry · doi:10.1016/j.trac.2019.115769 · Cited by 226 · see citing works
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Review on new horizons of aggregation induced emission: from design to development
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High‐Performance Quinoline‐Malononitrile Core as a Building Block for the Diversity‐Oriented Synthesis of AIEgens
Guo, Z., Yan, C., & Zhu, W. (2019) · Angewandte Chemie International Edition · doi:10.1002/anie.201913249 · Cited by 213 · see citing works
Recent advances in innovative strategies for enhanced cancer photodynamic therapy
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“A series of push-pull AIEgens synthesized by coupling diphenylamine group with different electron-withdrawing groups on carbazolyl rings also exhibit enhanced 1O2 generation capability [157].”
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ACQ‐to‐AIE Transformation: Tuning Molecular Packing by Regioisomerization for Two‐Photon NIR Bioimaging
Li, Y., Liu, S., Ni, H., Zhang, H., Zhang, H., Chuah, C., Ma, C., Wong, K. S., Lam, J. W. Y., Kwok, R. T. K., et al. (2020) · Angewandte Chemie International Edition · doi:10.1002/anie.202005785 · Cited by 197 · see citing works
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Three‐Pronged Attack by Homologous Far‐red/NIR AIEgens to Achieve 1+1+1>3 Synergistic Enhanced Photodynamic Therapy
Xu, W., Lee, M. M. S., Nie, J., Zhang, Z., Kwok, R. T. K., Lam, J. W. Y., Xu, F., Wang, D., & Tang, B. Z. (2020) · Angewandte Chemie International Edition · doi:10.1002/anie.202000740 · Cited by 192 · see citing works
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AIE-based cancer theranostics
Gao, M., & Tang, B. Z. (2019) · Coordination Chemistry Reviews · doi:10.1016/j.ccr.2019.213076 · Cited by 187 · see citing works
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Functional black phosphorus nanosheets for mitochondria-targeting photothermal/photodynamic synergistic cancer therapy
Yang, X., Wang, D., Zhu, J., Xue, L., Ou, C., Wang, W., Lu, M., Song, X., & Dong, X. (2019) · Chemical Science · doi:10.1039/c8sc04844d · Cited by 180 · see citing works
Antibacterial Hybrid Hydrogels
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Tumor‐Exocytosed Exosome/Aggregation‐Induced Emission Luminogen Hybrid Nanovesicles Facilitate Efficient Tumor Penetration and Photodynamic Therapy
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Aggregation‐Induced Nonlinear Optical Effects of AIEgen Nanocrystals for Ultradeep In Vivo Bioimaging
Zheng, Z., Li, D., Liu, Z., Peng, H., Sung, H. H. Y., Kwok, R. T. K., Williams, I. D., Lam, J. W. Y., Qian, J., & Tang, B. Z. (2019) · Advanced Materials · doi:10.1002/adma.201904799 · Cited by 162 · see citing works
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Recent progress in efficient organic two-photon dyes for fluorescence imaging and photodynamic therapy
Xu, L., Zhang, J., Yin, L., Long, X., Zhang, W., & Zhang, Q. (2020) · Journal of Materials Chemistry C · doi:10.1039/d0tc00563k · Cited by 162 · see citing works
Platinum-carbon-integrated nanozymes for enhanced tumor photodynamic and photothermal therapy
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AIE-based theranostic systems for detection and killing of pathogens
He, X., Xiong, L., Zhao, Z., Wang, Z., Luo, L., Lam, J. W. Y., Kwok, R. T. K., & Tang, B. Z. (2019) · Theranostics · doi:10.7150/thno.31844 · Cited by 148 · see citing works
“Meanwhile, in the killing of pathogens, AIE-based supramolecular nanostructures with photodynamic inactivation (PDI) effect have become promising options for antimicrobial practices[60-62].”
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Probing Polarity and Heterogeneity of Lipid Droplets in Live Cells Using a Push–Pull Fluorophore
Collot, M., Bou, S., Fam, K. T., Richert, L., Mély, Y., Danglot, L., & Klymchenko, A. S. (2018) · Analytical Chemistry · doi:10.1021/acs.analchem.8b04218 · Cited by 149 · see citing works
Solvatochromic Near-Infrared Probe for Polarity Mapping of Biomembranes and Lipid Droplets in Cells under Stress
Ashoka, A. H., Ashokkumar, P., Kovtun, Y. P., & Klymchenko, A. S. (2019) · The Journal of Physical Chemistry Letters · doi:10.1021/acs.jpclett.9b00668 · Cited by 143 · see citing works
Covalent Organic Framework for Improving Near‐Infrared Light Induced Fluorescence Imaging through Two‐Photon Induction
Zeng, J., Wang, X., Xie, B., Li, M., & Zhang, X. (2019) · Angewandte Chemie International Edition · doi:10.1002/anie.201912594 · Cited by 142 · see citing works
Photodynamic therapy based on organic small molecular fluorescent dyes
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Two-photon-absorbing ruthenium complexes enable near infrared light-driven photocatalysis
Han, G., Li, G., Huang, J., Han, C., Turró, C., & Sun, Y. (2022) · Nature Communications · doi:10.1038/s41467-022-29981-3 · Cited by 138 · see citing works
Donor–Acceptor Modulating of Ionic AIE Photosensitizers for Enhanced ROS Generation and NIR‐II Emission
Yang, X., Wang, X., Zhang, X., Zhang, J., Lam, J. W. Y., Sun, H., Yang, J., Liang, Y., & Tang, B. Z. (2024) · Advanced Materials · doi:10.1002/adma.202402182 · Cited by 134 · see citing works
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Mitochondria-targeted smart AIEgens: Imaging and therapeutics
Li, H., Kim, H., Zhang, C., Zeng, S., Chen, Q., Jia, L., Wang, J., Peng, X., & Yoon, J. (2022) · Coordination Chemistry Reviews · doi:10.1016/j.ccr.2022.214818 · Cited by 133 · see citing works
Emerging near infrared fluorophore: Dicyanoisophorone-based small-molecule fluorescent probes with large stokes shifts for bioimaging
Dai, L., Zhang, Q., Ma, Q., & Lin, W. (2023) · Coordination Chemistry Reviews · doi:10.1016/j.ccr.2023.215193 · Cited by 133 · see citing works
Persistent Photoconductivity of Metal Oxide Semiconductors
Gao, S., Qiu, L., Zhang, J., Han, W., Ramakrishna, S., & Long, Y. (2024) · ACS Applied Electronic Materials · doi:10.1021/acsaelm.3c01549 · Cited by 136 · see citing works
Red AIE‐Active Fluorescent Probes with Tunable Organelle‐Specific Targeting
Alam, P., He, W., Leung, N. L. C., Ma, C., Kwok, R. T. K., Lam, J. W. Y., Sung, H. H. Y., Williams, I. D., Wong, K. S., & Tang, B. Z. (2020) · Advanced Functional Materials · doi:10.1002/adfm.201909268 · Cited by 132 · see citing works
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In Response to Precision Medicine: Current Subcellular Targeting Strategies for Cancer Therapy
Li, Z., Zou, J., & Chen, X. S. (2022) · Advanced Materials · doi:10.1002/adma.202209529 · Cited by 132 · see citing works
Fluorescent Chromophores Containing the Nitro Group: Relatively Unexplored Emissive Properties
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Hybrid drug nanocrystals
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Pathogen-Specific Polymeric Antimicrobials with Significant Membrane Disruption and Enhanced Photodynamic Damage To Inhibit Highly Opportunistic Bacteria
Xiao, F., Cao, B., Wang, C., Guo, X., Li, M., Xing, D., & Hu, X. (2019) · ACS Nano · doi:10.1021/acsnano.8b07251 · Cited by 116 · see citing works
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In Vivo Three‐Photon Imaging of Lipids using Ultrabright Fluorogens with Aggregation‐Induced Emission
Wang, S., Li, X., Chong, S. Y., Wang, X., Chen, H., Chen, C., Ng, L. G., Wang, J., & Liu, B. (2021) · Advanced Materials · doi:10.1002/adma.202007490 · Cited by 115 · see citing works
Multifunctional Two-Photon AIE Luminogens for Highly Mitochondria-Specific Bioimaging and Efficient Photodynamic Therapy
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Molecular Engineering of Efficient Singlet Oxygen Generators with Near‐Infrared AIE Features for Mitochondrial Targeted Photodynamic Therapy
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Beyond Photo: Xdynamic Therapies in Fighting Cancer
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Carbon Dots with Absorption Red-Shifting for Two-Photon Fluorescence Imaging of Tumor Tissue pH and Synergistic Phototherapy
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Bright Bacterium for Hypoxia‐Tolerant Photodynamic Therapy Against Orthotopic Colon Tumors by an Interventional Method
Zhu, D., Zhang, J., Luo, G., Duo, Y., & Tang, B. Z. (2021) · Advanced Science · doi:10.1002/advs.202004769 · Cited by 109 · see citing works
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Review on recent trends and prospects in π‐conjugated luminescent aggregates for biomedical applications
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Aggregationsinduzierte Emission: Einblicke auf Aggregatebene
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Polarity Mapping of Cells and Embryos by Improved Fluorescent Solvatochromic Pyrene Probe
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Bright Aggregation-Induced Emission Nanoparticles for Two-Photon Imaging and Localized Compound Therapy of Cancers
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Aggregation-Induced Generation of Reactive Oxygen Species: Mechanism and Photosensitizer Construction
Ni, J., Wang, Y., Zhang, H., Sun, J. Z., & Tang, B. Z. (2021) · Molecules · doi:10.3390/molecules26020268 · Cited by 102 · see citing works
“As reported, triphenylamine moiety has been widely used to enhance the AIE effect of the PSs and pyridinium group is proved to be a specific targeting site toward mitochondria [55,68,69].”
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Near-infrared light-regulated cancer theranostic nanoplatform based on aggregation-induced emission luminogen encapsulated upconversion nanoparticles
Jin, G., He, R., Liu, Q., Lin, M., Dong, Y., Li, K., Tang, B. Z., Liu, B., & Xu, F. (2018) · Theranostics · doi:10.7150/thno.30174 · Cited by 101 · see citing works
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Highly photostable two-photon NIR AIEgens with tunable organelle specificity and deep tissue penetration
Niu, G., Zhang, R., Gu, Y., Wang, J., Ma, C., Kwok, R. T. K., Lam, J. W. Y., Sung, H. H. Y., Williams, I. D., Wong, K. S., et al. (2019) · Biomaterials · doi:10.1016/j.biomaterials.2019.04.002 · Cited by 101 · see citing works
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High‐Fidelity Trapping of Spatial–Temporal Mitochondria with Rational Design of Aggregation‐Induced Emission Probes
Zhang, J., Wang, Q., Guo, Z., Zhang, S., Yan, C., Tian, H., & Zhu, W. (2019) · Advanced Functional Materials · doi:10.1002/adfm.201808153 · Cited by 100 · see citing works
Tuning Push–Pull Electronic Effects of AIEgens to Boost the Theranostic Efficacy for Colon Cancer
Feng, H., Zou, S., Chen, M., Xiong, F., Lee, M., Fang, L., & Tang, B. Z. (2020) · Journal of the American Chemical Society · doi:10.1021/jacs.0c02434 · Cited by 100 · see citing works
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Exploration of High Efficiency AIE‐Active Deep/Near‐Infrared Red Emitters in OLEDs with High‐Radiance
Wan, Q., Tong, J., Zhang, B., Li, Y. Q., Wang, Z., & Tang, B. Z. (2019) · Advanced Optical Materials · doi:10.1002/adom.201901520 · Cited by 99 · see citing works
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Temperature triggered high-performance carbon dots with robust solvatochromic effect and self-quenching-resistant deep red solid state fluorescence for specific lipid droplet imaging
Gao, D., Liu, A., Zhang, Y., Zhu, Y., Wei, D., Sun, J., Luo, H., & Fan, H. (2021) · Chemical Engineering Journal · doi:10.1016/j.cej.2021.128984 · Cited by 99 · see citing works
High-Performance Near-Infrared Aggregation-Induced Emission Luminogen with Mitophagy Regulating Capability for Multimodal Cancer Theranostics
Li, Y., Zhuang, J., Lü, Y., Li, N., Gu, M., Xia, J., Zhao, N., & Tang, B. Z. (2021) · ACS Nano · doi:10.1021/acsnano.1c08928 · Cited by 99 · see citing works
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Versatile organic fluorescent probes for visualizing the dynamics of lipid droplets
Cao, M., Liu, Y., Xiang, C., Zheng, G., Xiong, Q., & Niu, G. (2024) · Coordination Chemistry Reviews · doi:10.1016/j.ccr.2024.216181 · Cited by 99 · see citing works
A Self‐Degradable Conjugated Polymer for Photodynamic Therapy with Reliable Postoperative Safety
Huang, H., Xie, W., Wan, Q., Mao, L., Hu, D., Sun, H., Zhang, X., & Wei, Y. (2021) · Advanced Science · doi:10.1002/advs.202104101 · Cited by 98 · see citing works
AIE Bioconjugates for Biomedical Applications
Liu, H., Xiong, L., Kwok, R. T. K., He, X., Lam, J. W. Y., & Tang, B. Z. (2020) · Advanced Optical Materials · doi:10.1002/adom.202000162 · Cited by 97 · see citing works
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In Situ Generation of Azonia-Containing Polyelectrolytes for Luminescent Photopatterning and Superbug Killing
Liu, X., Li, M., Han, T., Cao, B., Qiu, Z., Li, Y., Li, Q., Hu, Y., Liu, Z., Lam, J. W. Y., et al. (2019) · Journal of the American Chemical Society · doi:10.1021/jacs.9b04757 · Cited by 94 · see citing works
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Nano-photosensitizers for enhanced photodynamic therapy
Li, L., Song, X., Dong, X., & Li, B. (2021) · Photodiagnosis and Photodynamic Therapy · doi:10.1016/j.pdpdt.2021.102597 · Cited by 93 · see citing works
Apoptotic extracellular vesicles are metabolized regulators nurturing the skin and hair
Ma, L., Chen, C., Liu, D., Huang, Z., Li, J., Liu, H., Kwok, R. T. K., Tang, B. Z., Sui, B., Zhang, X., et al. (2022) · Bioactive Materials · doi:10.1016/j.bioactmat.2022.04.022 · Cited by 93 · see citing works
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Single injection and multiple treatments: An injectable nanozyme hydrogel as AIEgen reservoir and release controller for efficient tumor therapy
Zhu, D., Zheng, Z., Luo, G., Suo, M., Li, X., Duo, Y., & Tang, B. Z. (2021) · Nano Today · doi:10.1016/j.nantod.2021.101091 · Cited by 91 · see citing works
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A Mitochondria-Targeted and Viscosity-Sensitive Near-Infrared Fluorescent Probe for Visualization of Fatty Liver, Inflammation and Photodynamic Cancer Therapy
Fan, L., Zan, Q., Wang, X., Yu, X., Wang, S., Zhang, Y., Yang, Q., Lu, W., Shuang, S., & Dong, C. (2022) · Chemical Engineering Journal · doi:10.1016/j.cej.2022.137762 · Cited by 89 · see citing works
Full‐Color Emissive D‐D‐A Carbazole Luminophores: Red‐to‐NIR Mechano‐fluorochromism, Aggregation‐Induced Near‐Infrared Emission, and Application in Photodynamic Therapy
Chen, Z., Qin, H., Yin, Y., Deng, D., Qin, S., Li, N., Wang, K., & Sun, Y. M. (2022) · Chemistry - A European Journal · doi:10.1002/chem.202203797 · Cited by 89 · see citing works
Applications of red light photoredox catalysis in organic synthesis
Schade, A., & Mei, L. (2023) · Organic & Biomolecular Chemistry · doi:10.1039/d3ob00107e · Cited by 89 · see citing works
Lipid droplet‐targeted NIR AIE photosensitizer evoking concurrent ferroptosis and apoptosis
Jia, J., Ma, Z., Zhuang, J., Huo, L., Zhou, C., Li, N., & Zhao, N. (2024) · Aggregate · doi:10.1002/agt2.516 · Cited by 89 · see citing works
Recent Advances in Strategies to Enhance Photodynamic and Photothermal Therapy Performance of Single‐Component Organic Phototherapeutic Agents
Fang, L., Chen, Z., Dai, J., Pan, Y., Tu, Y., Meng, Q., Diao, Y., Yang, S., Guo, W., Li, L., et al. (2025) · Advanced Science · doi:10.1002/advs.202409157 · Cited by 88 · see citing works
Making the Best Use of Excited-State Energy: Multimodality Theranostic Systems Based on Second Near-Infrared (NIR-II) Aggregation-Induced Emission Luminogens (AIEgens)
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A review on realizing the modern optoelectronic applications through persistent photoconductivity
Sumanth, A., Ganapathi, K., Rao, M. S. R., & Dixit, T. (2022) · Journal of Physics D Applied Physics · doi:10.1088/1361-6463/ac7f66 · Cited by 82 · see citing works
AIE-Active Photosensitizers: Manipulation of Reactive Oxygen Species Generation and Applications in Photodynamic Therapy
Yu, H., Chen, B., Huang, H., He, Z., Sun, J., Wang, G., Gu, X., & Tang, B. Z. (2022) · Biosensors · doi:10.3390/bios12050348 · Cited by 81 · see citing works
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Functionalization of Silk by AIEgens through Facile Bioconjugation: Full‐Color Fluorescence and Long‐Term Bioimaging
Liu, C., Bai, H., He, B., He, X., Zhang, J., Chen, C., Qiu, Y., Hu, R., Zhao, F., Zhang, Y., et al. (2021) · Angewandte Chemie International Edition · doi:10.1002/anie.202015592 · Cited by 80 · see citing works
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Single-molecule photosensitizers for NIR-II fluorescence and photoacoustic imaging guided precise anticancer phototherapy
Gu, H., Liu, W., Sun, W. C., Du, J., Fan, J., & Peng, X. (2022) · Chemical Science · doi:10.1039/d2sc02879d · Cited by 76 · see citing works
Dual-Functional NIR AIEgens for High-Fidelity Imaging of Lysosomes in Cells and Photodynamic Therapy
Dai, Y., He, F., Ji, H., Zhao, X., Misal, S., & Qi, Z. (2019) · ACS Sensors · doi:10.1021/acssensors.9b02090 · Cited by 75 · see citing works
Two-Photon Absorption: An Open Door to the NIR-II Biological Window?
Shaw, P. A., Forsyth, E., Haseeb, F., Yang, S., Bradley, M., & Klausen, M. (2022) · Frontiers in Chemistry · doi:10.3389/fchem.2022.921354 · Cited by 75 · see citing works
“Toluene 538 528 755 ≈636 0.02 (solid state) 1076 1020 n.d. 887 n.d. 18b n.d. (Zheng et al., 2018) 75 NP (aq.)”
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Phototherapy and optical waveguides for the treatment of infection
Wang, D., Kuzma, M. L., Tan, X., He, T., Dong, C., Liu, Z., & Yang, J. Y. (2021) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2021.114036 · Cited by 72 · see citing works
Nanoprobes with aggregation-induced emission for theranostics
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Authors: Zheng, Z., Zhang, T., Liu, H., Chen, Y., Kwok, R. T. K., Ma, C., Zhang, P., Sung, H. H. Y., Williams, I. D., Lam, J. W. Y., Wong, K. S., & Tang, B. Z.
Affiliations: Hong Kong University of Science and Technology (HK)
Corresponding author: Tang, Ben Zhong
ORCID: Zheng, Zheng
Zhang, Tianfu
Liu, Haixiang
Chen, Yuncong
Kwok, Ryan T. K.
Ma, Chao
Zhang, Pengfei
Sung, Herman H. Y.
Williams, Ian D.
Lam, Jacky W. Y.
Wong, Kam Sing
Tang, Ben Zhong
Venue: ACS Nano
Publisher: American Chemical Society (ACS)
Published: 2018-08-03
Volume: 12
Issue: 8
Pages: 8145-8159
ISSN: 1936-0851 (ISSN-L)
1936-086X
DOI: 10.1021/acsnano.8b03138
OpenAlex: W2885215503
Cited by: 340
References: 84
Citations by year: 2026: 16 · 2025: 22 · 2024: 30 · 2023: 34 · 2022: 55 · 2021: 69 · 2020: 54 · 2019: 53 · 2018: 7
FWCI: 17.07
Type: journal article
Language: en
Open access: closed
Locations: ACS Nano (publishedVersion)
PubMed (publishedVersion)
Rare & Special e-Zone (The Hong Kong University of Science and Technology) (submittedVersion)
Funders: Research Grants Council, University Grants Committee (C6009-17G, C2014-15G, 16308016, AoE/P-02/12, A-HKUST605/16)
Innovation and Technology Commission (ITCCNERC14SC01)
National Natural Science Foundation of China (21788102)
Science and Technology Plan of Shenzhen (JCYJ20160229205601482, JCYJ20140425170011516)
Topics: Physical Sciences › Materials Science › Materials Chemistry › Luminescence and Fluorescent Materials
Physical Sciences › Chemistry › Spectroscopy › Molecular Sensors and Ion Detection
Physical Sciences › Engineering › Biomedical Engineering › Nonlinear Optical Materials Studies
Keywords: aggregation-induced emission, far-red fluorescence, two-photon absorption, push-pull effect, lipid droplet targeting, mitochondrial targeting, two-photon fluorescence imaging, photodynamic therapy, singlet oxygen generation, cancer cell ablation, deep tissue penetration
MeSH terms: Animals, Antineoplastic Agents, Cell Survival, Dose-Response Relationship, Drug, Drug Screening Assays, Antitumor, Fluorescent Dyes, HeLa Cells, Humans, Infrared Rays, Mice, Nude, Photochemotherapy, Protons, Structure-Activity Relationship, Tumor Cells, Cultured, Organelles, Molecular Structure, Cell Proliferation, Mice, Optical Imaging

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Bright Near-Infrared Aggregation-Induced Emission Luminogens with Strong Two-Photon Absorption, Excellent Organelle Specificity, and Efficient Photodynamic Therapy Potential

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