The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
In Situ Nanoreactor for Photosynthesizing H2 Gas To Mitigate Oxidative Stress in Tissue Inflammation
Abstract
Hydrogen gas can reduce cytotoxic reactive oxygen species (ROS) that are produced in inflamed tissues. Inspired by natural photosynthesis, this work proposes a multicomponent nanoreactor (NR) that comprises chlorophyll a, l-ascorbic acid, and gold nanoparticles that are encapsulated in a liposomal (Lip) system that can produce H 2 gas in situ upon photon absorption to mitigate inflammatory responses. Unlike a bulk system that contains free reacting molecules, this Lip NR system provides an optimal reaction environment, facilitating rapid activation of the photosynthesis of H 2 gas, locally providing a high therapeutic concentration thereof. The photodriven NR system reduces the degrees of overproduction of ROS and pro-inflammatory cytokines both in vitro in RAW264.7 cells and in vivo in mice with paw inflammation that is induced by lipopolysaccharide (LPS). Histological examinations of tissue sections confirm the ability of the NR system to reduce LPS-induced inflammation. Experimental results indicate that the Lip NR system that can photosynthesize H 2 gas has great potential for mitigating oxidative stress in tissue inflammation.
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Tet2 is required to resolve inflammation by recruiting Hdac2 to specifically repress IL-6
Zhang, Q., Zhao, K., Shen, Q., Han, Y., Gu, Y., Li, X., Zhao, D., Liu, Y., Wang, C., Zhang, X., et al. (2015) · Nature · doi:10.1038/nature15252 · Cited by 807
HPLC methods for simultaneous determination of ascorbic and dehydroascorbic acids
Nováková, L., Solich, P., & Solichová, D. (2008) · TrAC Trends in Analytical Chemistry · doi:10.1016/j.trac.2008.08.006 · Cited by 210
Cited by
Yang, B., Chen, Y., & Shi, J. (2019) · Advanced Materials · doi:10.1002/adma.201901778 · Cited by 601
Wound Dressing: From Nanomaterials to Diagnostic Dressings and Healing Evaluations
Zeng, Q., Qi, X., Shi, G., Zhang, M., & Haick, H. (2022) · ACS Nano · doi:10.1021/acsnano.1c08411 · Cited by 532
Design of therapeutic biomaterials to control inflammation
Tu, Z., Zhong, Y., Hu, H., Shao, D., Haag, R., Schirner, M., Lee, J., Sullenger, B., & Leong, K. W. (2022) · Nature Reviews Materials · doi:10.1038/s41578-022-00426-z · Cited by 513
Yang, N., Gong, F., Liu, B., Hao, Y., Chao, Y., Lei, H., Yang, X., Gong, Y., Wang, X., Liu, Z., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-29938-6 · Cited by 196
Mac, C.-H., Chan, H.-Y., Lin, Y.-H., Sharma, A. K., Song, H.-L., Chan, Y.-S., Lin, K.-J., Lin, Y.-J., & Sung, H.-W. (2022) · Biomaterials · doi:10.1016/j.biomaterials.2022.121574 · Cited by 60
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Metadata
- Authors
- Wan, W.-L., Lin, Y.-J., Chen, H.-L., Huang, C.-C., Shih, P.-C., Bow, Y.-R., Chia, W.-T., & Sung, H.-W.
- Venue
- Journal of the American Chemical Society
- Publisher
- American Chemical Society (ACS)
- Published
- 2017-09-11
- Volume
- 139
- Issue
- 37
- Pages
- 12923-12926
- ISSN
- 0002-7863 (ISSN-L)
- 1520-5126
- OpenAlex
- W2751462512
- Cited by
- 185
- References
- 2
- FWCI
- 12.13
- Type
- journal article
- Language
- en
- Open access
- closed
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