The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Photoactivatable Organic Semiconducting Pro-nanoenzymes
Abstract
Therapeutic enzymes hold great promise for cancer therapy; however, in vivo remote control of enzymatic activity to improve their therapeutic specificity remains challenging. This study reports the development of an organic semiconducting pro-nanoenzyme (OSPE) with a photoactivatable feature for metastasis-inhibited cancer therapy. Upon near-infrared (NIR) light irradiation, this pro-nanoenzyme not only generates cytotoxic singlet oxygen ( 1 O 2 ) for photodynamic therapy (PDT), but also triggers a spontaneous cascade reaction to induce the degradation of ribonucleic acid (RNA) specifically in tumor microenvironment. More importantly, OSPE-mediated RNA degradation is found to downregulate the expression of metastasis-related proteins, contributing to the inhibition of metastasis after treatment. Such a photoactivated and cancer-specific synergistic therapeutic action of OSPE enables complete inhibition of tumor growth and lung metastasis in mouse xenograft model, which is not possible for the counterpart PDT nanoagent. Thus, our study proposes a phototherapeutic-proenzyme approach toward complete-remission cancer therapy.
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Cites
A small-molecule dye for NIR-II imaging
Antaris, A. L., Chen, H., Cheng, K., Sun, Y., Hong, G., Qu, C., Diao, S., Deng, Z., Hu, X., Zhang, B., et al. (2016) · Nature Materials · doi:10.1038/nmat4476 · Cited by 1,778
Small conjugate-based theranostic agents: an encouraging approach for cancer therapy
Kumar, R., Shin, W. S., Sunwoo, K., Kim, W. Y., Koo, S., Bhuniya, S., & Kim, J. S. (2015) · Chemical Society Reviews · doi:10.1039/c5cs00224a · Cited by 381
Cited by
Overcoming barriers in photodynamic therapy harnessing nano-formulation strategies
Xie, J., Wang, Y., Choi, W., Jangili, P., Ge, Y., Xu, Y., Kang, J., Liu, L., Zhang, B., Xie, Z., et al. (2021) · Chemical Society Reviews · doi:10.1039/d0cs01370f · Cited by 522
Semiconducting Polymer Nanomaterials as Near-Infrared Photoactivatable Protherapeutics for Cancer
Li, J., & Pu, K. (2020) · Accounts of Chemical Research · doi:10.1021/acs.accounts.9b00569 · Cited by 412
Self-citationHemicyanine‐Based Near‐Infrared Activatable Probes for Imaging and Diagnosis of Diseases
Zeng, Z., Liew, S. S., Wei, X., & Pu, K. (2021) · Angewandte Chemie International Edition · doi:10.1002/anie.202107877 · Cited by 359
Self-citationOrganic Semiconducting Pro‐nanostimulants for Near‐Infrared Photoactivatable Cancer Immunotherapy
Li, J., Cui, D., Huang, J., He, S., Yang, Z., Zhang, Y., Luo, Y., & Pu, K. (2019) · Angewandte Chemie International Edition · doi:10.1002/anie.201906288 · Cited by 304
Self-citationPhotodynamic therapy: Innovative approaches for antibacterial and anticancer treatments
Kolarikova, M., Hosikova, B., Dilenko, H., Barton‐Tomankova, K., Valkova, L., Bajgar, R., Malina, L., & Kolarova, H. (2023) · Medicinal Research Reviews · doi:10.1002/med.21935 · Cited by 282
Metadata
- Authors
- Li, J., Huang, J., Lyu, Y., Huang, J., Jiang, Y., Xie, C., & Pu, K.
- Venue
- Journal of the American Chemical Society
- Publisher
- American Chemical Society (ACS)
- Published
- 2019-02-11
- Volume
- 141
- Issue
- 9
- Pages
- 4073-4079
- ISSN
- 0002-7863 (ISSN-L)
- 1520-5126
- OpenAlex
- W2914693810
- Cited by
- 261
- References
- 2
- FWCI
- 17.66
- Type
- journal article
- Language
- en
- Open access
- closed
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