The DOI matches its Crossref record; 46 of the 46 references it cites were found in a registry or an index.
Organic Semiconducting Pro‐nanostimulants for Near‐Infrared Photoactivatable Cancer Immunotherapy
Abstract
In this study, an organic semiconducting pro‐nanostimulant (OSPS) with a near‐infrared (NIR) photoactivatable immunotherapeutic action for synergetic cancer therapy is presented. OSPS comprises a semiconducting polymer nanoparticle (SPN) core and an immunostimulant conjugated through a singlet oxygen (1 O 2) cleavable linkers. Upon NIR laser irradiation, OSPS generates both heat and 1 O 2 to exert combinational phototherapy not only to ablate tumors but also to produce tumor‐associated antigens. More importantly, NIR irradiation triggers the cleavage of 1 O 2‐cleavable linkers, triggering the remote release of the immunostimulants from OSPS to modulate the immunosuppressive tumor microenvironment. Thus, the released tumor‐associated antigens in conjunction with activated immunostimulants induce a synergistic antitumor immune response after OSPS‐mediated phototherapy, resulting in the inhibited growth of both primary/distant tumors and lung metastasis in a mouse xenograft model, which is not observed for sole phototherapy.
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Semiconducting Polymer Nanomaterials as Near-Infrared Photoactivatable Protherapeutics for Cancer
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Self-citationResponsive Exosome Nano-bioconjugates for Synergistic Cancer Therapy
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Metadata
- Authors
- Li, J., Cui, D., Huang, J., He, S., Yang, Z., Zhang, Y., Luo, Y., & Pu, K.
- Venue
- Angewandte Chemie International Edition
- Publisher
- Wiley
- Published
- 2019-07-30
- Volume
- 58
- Issue
- 36
- Pages
- 12680-12687
- ISSN
- 1433-7851 (ISSN-L)
- 1521-3773
- OpenAlex
- W2955833565
- Cited by
- 304
- References
- 46
- FWCI
- 18.74
- Type
- journal article
- Language
- en
- Open access
- closed
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- Li, J., Cui, D., Huang, J., He, S., Yang, Z., Zhang, Y., Luo, Y., & Pu, K. (2019). Organic Semiconducting Pro‐nanostimulants for Near‐Infrared Photoactivatable Cancer Immunotherapy. Angewandte Chemie International Edition. https://doi.org/10.1002/anie.201906288
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