The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Bioinspired Construction of a Nanozyme-Based H2O2 Homeostasis Disruptor for Intensive Chemodynamic Therapy
Abstract
The insufficient intracellular H 2 O 2 level in tumor cells is closely associated with the limited efficacy of chemodynamic therapy (CDT). Despite tremendous efforts, engineering CDT agents with a straightforward and secure H 2 O 2 supplying ability remains a great challenge. Inspired by the balance of H 2 O 2 generation and elimination in cancer cells, herein, a nanozyme-based H 2 O 2 homeostasis disruptor is fabricated to elevate the intracellular H 2 O 2 level through facilitating H 2 O 2 production and restraining H 2 O 2 elimination for enhanced CDT. In the formulation, the disruptor with superoxide dismutase-mimicking activity can convert O 2 •– to H 2 O 2, promoting the production of H 2 O 2 . Simultaneously, the suppression of catalase activity and depletion of glutathione by the disruptor weaken the transformation of H 2 O 2 to H 2 O. Thus, the well-defined system could perturb the H 2 O 2 balance and give rise to the accumulation of H 2 O 2 in cancer cells. The raised H 2 O 2 level would ultimately amplify the Fenton-like reaction-based CDT efficiency. Our work not only paves a way to engineer alternative CDT agents with a H 2 O 2 supplying ability for intensive CDT but also provides new insights into the construction of bioinspired materials.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Intrinsic peroxidase-like activity of ferromagnetic nanoparticles
Gao, L., Zhuang, J., Nie, L., Zhang, J., Zhang, Y., Gu, N., Wang, T., Feng, J., Yang, D., Perrett, S., et al. (2007) · Nature Nanotechnology · doi:10.1038/nnano.2007.260 · Cited by 7,483
Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach?
Trachootham, D., Alexandre, J., & Huang, P. (2009) · Nature Reviews Drug Discovery · doi:10.1038/nrd2803 · Cited by 5,452
Alsaiari, S. K., Patil, S., Alyami, M., Alamoudi, K. O., Aleisa, F. A., Merzaban, J. S., Li, M., & Khashab, N. M. (2018) · Journal of the American Chemical Society · doi:10.1021/jacs.7b11754 · Cited by 517
Cited by
Jomova, K., Alomar, S. Y., Alwasel, S. H., Nepovimova, E., Kuca, K., & Valko, M. (2024) · Archives of Toxicology · doi:10.1007/s00204-024-03696-4 · Cited by 1,445
Niu, B., Liao, K., Zhou, Y., Wen, T., Quan, G., Pan, X., & Wu, C. (2021) · Biomaterials · doi:10.1016/j.biomaterials.2021.121110 · Cited by 1,168
Zhou, Y., Fan, S., Feng, L., Huang, X., & Chen, X. (2021) · Advanced Materials · doi:10.1002/adma.202104223 · Cited by 463
Zeng, S., Liu, X., Kafuti, Y. S., Kim, H., Wang, J., Peng, X., Li, H., & Yoon, J. (2023) · Chemical Society Reviews · doi:10.1039/d2cs00799a · Cited by 341
Multifunctional metal–organic framework heterostructures for enhanced cancer therapy
Liu, J., Huang, J., Zhang, L., & Lei, J. (2021) · Chemical Society Reviews · doi:10.1039/d0cs00178c · Cited by 285
Self-citation
Metadata
- Authors
- Sang, Y., Cao, F., Li, W., Zhang, L., You, Y., Deng, Q., Dong, K., Ren, J., & Qu, X.
- Venue
- Journal of the American Chemical Society
- Publisher
- American Chemical Society (ACS)
- Published
- 2020-02-26
- Volume
- 142
- Issue
- 11
- Pages
- 5177-5183
- ISSN
- 0002-7863 (ISSN-L)
- 1520-5126
- OpenAlex
- W3008370485
- Cited by
- 591
- References
- 3
- FWCI
- 28.75
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Bioinspired Construction of a Nanozyme-Based H2O2 Homeostasis Disruptor for Intensive Chemodynamic Therapy. https://app.cochat.ai/papers/10.1021/jacs.9b12873
- The paper
- Sang, Y., Cao, F., Li, W., Zhang, L., You, Y., Deng, Q., Dong, K., Ren, J., & Qu, X. (2020). Bioinspired Construction of a Nanozyme-Based H2O2 Homeostasis Disruptor for Intensive Chemodynamic Therapy. Journal of the American Chemical Society. https://doi.org/10.1021/jacs.9b12873
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
