The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Induction of Apoptosis in Cancer Cells by Bilberry (Vaccinium myrtillus) and the Anthocyanins
Abstract
Among ethanol extracts of 10 edible berries, bilberry extract was found to be the most effective at inhibiting the growth of HL60 human leukemia cells and HCT116 human colon carcinoma cells in vitro. Bilberry extract induced apoptotic cell bodies and nucleosomal DNA fragmentation in HL60 cells. The proportion of apoptotic cells induced by bilberry extract in HCT116 was much lower than that in HL60 cells, and DNA fragmentation was not induced in the former. Of the extracts tested, that from bilberry contained the largest amounts of phenolic compounds, including anthocyanins, and showed the greatest 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activity. Pure delphinidin and malvidin, like the glycosides isolated from the bilberry extract, induced apoptosis in HL60 cells. These results indicate that the bilberry extract and the anthocyanins, bearing delphinidin or malvidin as the aglycon, inhibit the growth of HL60 cells through the induction of apoptosis. Only pure delphinidin and the glycoside isolated from the bilberry extract, but not malvidin and the glycoside, inhibited the growth of HCT116 cells.
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Citations
Cites
Colorimetry of Total Phenolics with Phosphomolybdic-Phosphotungstic Acid Reagents
Singleton, V. L., & Rossi, J. A. (1965) · American Journal of Enology and Viticulture · doi:10.5344/ajev.1965.16.3.144 · Cited by 24,852
Cited by
Review of methods to determine antioxidant capacities
Karadag, A., Ozcelik, B., & Saner, S. (2009) · Food Analytical Methods · doi:10.1007/s12161-008-9067-7 · Cited by 753
Effects of anthocyanins on the prevention and treatment of cancer
Lin, B., Gong, C., Song, H., & Cui, Y. (2017) · British Journal of Pharmacology · doi:10.1111/bph.13627 · Cited by 435
Anthocyanins Are Efficiently Absorbed from the Stomach in Anesthetized Rats
Talavéra, S., Felgines, C., Texier, O., Lamaison, J.-L., Besson, C., & Rémésy, C. (2003) · The Journal of Nutrition · doi:10.1093/jn/133.12.4178 · Cited by 296
Delphinidin Prevents Muscle Atrophy and Upregulates miR-23a Expression
Murata, M., Nonaka, H., Komatsu, S., Goto, M., Morozumi, M., Yamada, S., Lin, I.-C., Yamashita, S., & Tachibana, H. (2017) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.6b03661 · Cited by 47
Metadata
- Authors
- Katsube, N., Iwashita, K., Tsushida, T., Yamaki, K., & Kobori, M.
- Venue
- Journal of Agricultural and Food Chemistry
- Publisher
- American Chemical Society (ACS)
- Published
- 2002-11-26
- Volume
- 51
- Issue
- 1
- Pages
- 68-75
- ISSN
- 0021-8561 (ISSN-L)
- 1520-5118
- OpenAlex
- W1980423337
- Cited by
- 442
- References
- 1
- FWCI
- 9.76
- Type
- journal article
- Language
- en
- Open access
- closed
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