The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
Insulin Secretion by Bioactive Anthocyanins and Anthocyanidins Present in Fruits
Abstract
Anthocyanins are responsible for a variety of bright colors including red, blue, and purple in fruits, vegetables, and flowers and are consumed as dietary polyphenols. Anthocyanin-containing fruits are implicated in a decrease in coronary heart disease and are used in antidiabetic preparations. In the present study, we have determined the ability of anthocyanins, cyanidin-3-glucoside (1), delphinidin-3-glucoside (2), cyanidin-3-galactoside (3), and pelargonidin-3-galactoside (4), and anthocyanidins, cyanidin (5), delphinidin (6), pelargonidin (7), malvidin (8), and petunidin (9), to stimulate insulin secretion from rodent pancreatic beta-cells (INS-1 832/13) in vitro. The compounds were tested in the presence of 4 and 10 mM glucose concentrations. Our results indicated that 1 and 2 were the most effective insulin secretagogues among the anthocyanins and anthocyanidins tested at 4 and 10 mM glucose concentrations. Pelargonidin-3-galactoside is one of the major anthocyanins, and its aglycone, pelargonidin, caused a 1.4-fold increase in insulin secretion at 4 mM glucose concentration. The rest of the anthocyanins and anthocyanidins tested in our assay had only marginal effects on insulin at 4 and 10 mM glucose concentrations.
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Cites
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Cited by
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Impact of Dietary Polyphenols on Carbohydrate Metabolism
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Antidiabetic Properties of Dietary Flavonoids: A Cellular Mechanism Review
Vinayagam, R., & Xu, B. (2015) · Nutrition & Metabolism · doi:10.1186/s12986-015-0057-7 · Cited by 597
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Metadata
- Authors
- Jayaprakasam, B., Vareed, S. K., Olson, L. K., & Nair, M. G.
- Venue
- Journal of Agricultural and Food Chemistry
- Publisher
- American Chemical Society (ACS)
- Published
- 2004-12-17
- Volume
- 53
- Issue
- 1
- Pages
- 28-31
- ISSN
- 0021-8561 (ISSN-L)
- 1520-5118
- OpenAlex
- W2016379859
- Cited by
- 425
- References
- 10
- FWCI
- 5.92
- Type
- journal article
- Language
- en
- Open access
- closed
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- Jayaprakasam, B., Vareed, S. K., Olson, L. K., & Nair, M. G. (2005). Insulin Secretion by Bioactive Anthocyanins and Anthocyanidins Present in Fruits. Journal of Agricultural and Food Chemistry. https://doi.org/10.1021/jf049018%2B
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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