The DOI matches its Crossref record.
Identification of Food-Derived Collagen Peptides in Human Blood after Oral Ingestion of Gelatin Hydrolysates
Abstract
In the present study, we identified several food-derived collagen peptides in human blood after oral ingestion of some gelatin hydrolysates. Healthy human volunteers ingested the gelatin hydrolysates (9.4-23 g) from porcine skin, chicken feet, and cartilage after 12 h of fasting. Negligible amounts of the peptide form of hydroxyproline (Hyp) were observed in human blood before the ingestion. After the oral ingestion, the peptide form of Hyp significantly increased and reached a maximum level (20-60 nmol/mL of plasma) after 1-2 h and then decreased to half of the maximum level at 4 h after the ingestion. Major constituents of food-derived collagen peptides in human serum and plasma were identified as Pro-Hyp. In addition, small but significant amounts of Ala-Hyp, Ala-Hyp-Gly, Pro-Hyp-Gly, Leu-Hyp, Ile-Hyp, and Phe-Hyp were contained.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cited by
Skin collagen through the lifestages: importance for skin health and beauty
Reilly, D. M., & Lozano, J. (2021) · Plastic and Aesthetic Research · doi:10.20517/2347-9264.2020.153 · Cited by 241
Bioactive peptides in cereals and legumes: agronomical, biochemical and clinical aspects.
Malaguti, M., Dinelli, G., Leoncini, E., Bregola, V., Bosi, S., Cicero, A., & Hrelia, S. (2014) · International Journal of Molecular Sciences · doi:10.3390/ijms151121120 · Cited by 180
Effects of Collagen Peptide Ingestion on UV-B-Induced Skin Damage
TANAKA, M., KOYAMA, Y.-I., & NOMURA, Y. (2009) · Bioscience, Biotechnology, and Biochemistry · doi:10.1271/bbb.80649 · Cited by 174
Vollmer, D. L., West, V. A., & Lephart, E. D. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19103059 · Cited by 132
Holwerda, A. M., & van Loon, L. J. C. (2022) · Nutrition Reviews · doi:10.1093/nutrit/nuab083 · Cited by 117
“Pro-Hyp is the most abundant peptide contained in collagen hydrolysate, and has been shown in vitro to be resistive to peptidase action in plasma.(123) Figure 3 Graphical representation of collagen-derived di- and tripeptide absorption from the intestinal lumen into the blood circulation.”
BackgroundYoon, H.-S., Cho, H. H., Cho, S., Lee, S.-R., Shin, M.-H., & Chung, J. H. (2014) · Journal of Medicinal Food · doi:10.1089/jmf.2013.3060 · Cited by 93
Bioavailability and Bioavailable Forms of Collagen after Oral Administration to Rats
Wang, L., Wang, Q., Qian, J., Liang, Q., Wang, Z., Xu, J., He, S., & Ma, H. (2015) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf5057502 · Cited by 53
Anaya, K., Podszun, M., Franco, O. L., de Almeida Gadelha, C. A., & Frank, J. (2020) · Plant Foods for Human Nutrition · doi:10.1007/s11130-020-00826-y · Cited by 24
Motwani, M. S., Khan, K., Pai, A., & Joshi, R. (2020) · Journal of Cosmetic Dermatology · doi:10.1111/jocd.13404 · Cited by 9
Lee, E., Ahn, D. K., Kim, J. H., Lee, S., Kim, H. J., Lee, H. K., & Shin, J. H. (2025) · Journal of Microbiology and Biotechnology · doi:10.4014/jmb.2507.07008 · Cited by 6
Metadata
- Authors
- Iwai, K., Hasegawa, T., Taguchi, Y., Morimatsu, F., Sato, K., Nakamura, Y., Higashi, A., Kido, Y., Nakabo, Y., & Ohtsuki, K.
- Venue
- Journal of Agricultural and Food Chemistry
- Publisher
- American Chemical Society (ACS)
- Published
- 2005-07-06
- Volume
- 53
- Issue
- 16
- Pages
- 6531-6536
- ISSN
- 0021-8561 (ISSN-L)
- 1520-5118
- OpenAlex
- W1978389916
- Cited by
- 405
- References
- 0
- FWCI
- 1.27
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
