Supplementing with Dietary Astaxanthin Combined with Collagen Hydrolysate Improves Facial Elasticity and Decreases Matrix Metalloproteinase-1 and -12 Expression: A Comparative Study with Placebo
Abstract
Photoaging accounts for most age-related changes in skin appearance. It has been suggested that both astaxanthin, a potent antioxidant, and collagen hydrolysate can be used as antiaging modalities in photoaged skin. However, there is no clinical study using astaxanthin combined with collagen hydrolysate. We investigated the effects of using a combination of dietary astaxanthin and collagen hydrolysate supplementation on moderately photoaged skin in humans. A total of 44 healthy subjects were recruited and treated with astaxanthin (2 mg/day) combined with collagen hydrolysate (3 g/day) or placebos, which were identical in appearance and taste to the active supplementation for 12 weeks. The elasticity and hydration properties of facial skin were evaluated using noninvasive objective devices. In addition, we also evaluated the expression of procollagen type I, fibrillin-1, matrix metalloproteinase-1 (MMP-1) and -12, and ultraviolet (UV)-induced DNA damage in artificially UV-irradiated buttock skin before and after treatment. The supplement group showed significant improvements in skin elasticity and transepidermal water loss in photoaged facial skin after 12 weeks compared with the placebo group. In the supplement group, expression of procollagen type I mRNA increased and expression of MMP-1 and -12 mRNA decreased compared with those in the placebo group. In contrast, there was no significant difference in UV-induced DNA damage between groups. These results demonstrate that dietary astaxanthin combined with collagen hydrolysate can improve elasticity and barrier integrity in photoaged human facial skin, and such treatment is well tolerated.
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Carotenoids improve the elasticity of skin.
“They have been shown to improve the elasticity, hydration and texture of skin; reduce TEWL; lighten the skin; reduce discoloration; and delay the signs of photoaging [222,231,232,233].”
From Bioactive Compounds for Skin Health: A Review (2021) · cites this paper as [233]
Carotenoids reduce discoloration.
“They have been shown to improve the elasticity, hydration and texture of skin; reduce TEWL; lighten the skin; reduce discoloration; and delay the signs of photoaging [222,231,232,233].”
From Bioactive Compounds for Skin Health: A Review (2021) · cites this paper as [233]
Supplementation with 10 mg of lutein and 2 mg of zeaxanthin isomers daily for 12 weeks lightens skin tone.
“A study by Juturu et al. showed that supplementation with 10 mg of lutein and 2 mg of zeaxanthin isomers daily for 12 weeks improves the appearance of skin and lightens skin tone [233].”
From Bioactive Compounds for Skin Health: A Review (2021) · cites this paper as [233]
Carotenoids delay the signs of photoaging.
“They have been shown to improve the elasticity, hydration and texture of skin; reduce TEWL; lighten the skin; reduce discoloration; and delay the signs of photoaging [222,231,232,233].”
From Bioactive Compounds for Skin Health: A Review (2021) · cites this paper as [233]
Carotenoids lighten the skin.
“They have been shown to improve the elasticity, hydration and texture of skin; reduce TEWL; lighten the skin; reduce discoloration; and delay the signs of photoaging [222,231,232,233].”
From Bioactive Compounds for Skin Health: A Review (2021) · cites this paper as [233]
Supplementation with 10 mg of lutein and 2 mg of zeaxanthin isomers daily for 12 weeks improves the appearance of skin.
“A study by Juturu et al. showed that supplementation with 10 mg of lutein and 2 mg of zeaxanthin isomers daily for 12 weeks improves the appearance of skin and lightens skin tone [233].”
From Bioactive Compounds for Skin Health: A Review (2021) · cites this paper as [233]
Carotenoids improve the texture of skin.
“They have been shown to improve the elasticity, hydration and texture of skin; reduce TEWL; lighten the skin; reduce discoloration; and delay the signs of photoaging [222,231,232,233].”
From Bioactive Compounds for Skin Health: A Review (2021) · cites this paper as [233]
Carotenoids improve the hydration of skin.
“They have been shown to improve the elasticity, hydration and texture of skin; reduce TEWL; lighten the skin; reduce discoloration; and delay the signs of photoaging [222,231,232,233].”
From Bioactive Compounds for Skin Health: A Review (2021) · cites this paper as [233]
Carotenoids reduce TEWL.
“They have been shown to improve the elasticity, hydration and texture of skin; reduce TEWL; lighten the skin; reduce discoloration; and delay the signs of photoaging [222,231,232,233].”
From Bioactive Compounds for Skin Health: A Review (2021) · cites this paper as [233]
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Beneficial effects of astaxanthin in cosmeceuticals with focus on emerging market trends
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Astaxanthin production and technology in Vietnam and other Asian countries
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Innovative Nutraceutical Approaches to Counteract the Signs of Aging
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Validation of the elastic angle for quantitative and visible evaluation of skin elasticity in vivo
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Cosmetic and Dermatological Application of Seaweed: Skincare Therapy-Cosmeceuticals
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Can Carotenoid Encapsulated Hydrogel Be a Promising Medium for Repairing Skin Damage
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Comparative Assessment of Nutraceuticals for Supporting Skin Health
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Innovative Nutraceutical Approaches to Counteract the Signs of Aging
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Safety assessment and pharmaceutical effects of astaxanthin: An overview
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Crustacea (Carotenoids Namely Astaxanthins) Against Cancer
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Clinical Applications of Haematococcus
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Gıda Takviyesi Olarak Astaksantin ve Sağlık Üzerine Etkileri
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Effect of Astaxanthin Cream on MMP-1 and SOD Expression in Wistar Rats Exposed to ultraviolet B
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ヘアレスマウスの紫外線誘発光老化に対するアスタキサンチン摂取の保護効果
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Hydrolyzed Collagen for Skin Aging Meta‐Analyses Are Unreliable
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Inconsistencies found in the meta-analysis on collagen supplementation
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- Authors
- Yoon, H.-S., Cho, H. H., Cho, S., Lee, S.-R., Shin, M.-H., & Chung, J. H.
- Affiliations
- Seoul National University (KR)
- Venue
- Journal of Medicinal Food
- Publisher
- SAGE Publications
- Published
- 2014-07
- Volume
- 17
- Issue
- 7
- Pages
- 810-816
- ISSN
- 1096-620X (ISSN-L)
- 1557-7600
- OpenAlex
- W1892448042
- Cited by
- 93
- References
- 28
- Citations by year
- 2026: 9 · 2025: 9 · 2024: 8 · 2023: 13 · 2022: 9 · 2021: 15 · 2020: 6 · 2019: 6 · 2018: 6 · 2017: 2 · 2016: 3 · 2015: 7
- FWCI
- 4.37
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Medicinal Food (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Dermatology › Skin Protection and Aging
- Health Sciences › Medicine › Dermatology › Facial Rejuvenation and Surgery Techniques
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › melanin and skin pigmentation
- Keywords
- astaxanthin, collagen peptides, dietary supplementation, photoaging, skin elasticity, MMP-1, matrix metalloproteinase-12, type I procollagen, fibrillin-1, transepidermal water loss, skin hydration, UV-induced DNA damage, skin barrier integrity, antioxidants
- MeSH terms
- Fibrillins, Fibrillin-1, Adult, Antioxidants, Collagen, DNA Damage, Double-Blind Method, Elasticity, Female, Humans, Microfilament Proteins, Middle Aged, Patient Compliance, RNA, Messenger, Skin, Ultraviolet Rays, Skin Aging, Dietary Supplements, Matrix Metalloproteinase 1, Collagen Type I, Xanthophylls, Asian People, Matrix Metalloproteinase 12, Adipokines
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