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Cited by 321

The DOI matches its Crossref record; 16 of the 16 references it cites were found in a registry or an index.

Antioxidant Activity of Isoflavones and Their Major Metabolites Using Different in Vitro Assays

Rüfer, Corinna E., Kulling, Sabine E.·2006·Journal of Agricultural and Food Chemistry
DOI 10.1021/jf053112o
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Abstract

Isoflavone phytoestrogens found mainly in soybeans and clover are widely studied phytochemicals. Genistein and daidzein, the major isoflavones found in soy, have received the most attention. However, they undergo extensive metabolism in the intestine and the liver, which might affect their biological properties, e.g. their antioxidant capacities. Furthermore, the biological activities of other naturally occurring isoflavones, for instance, glycitein from soy or biochanin A from red clover, have not yet been studied in detail. The aim of this study was to investigate the antioxidant activities of six naturally occurring isoflavones and their corresponding oxidative and bacterial metabolites. The oxygen radical absorbance capacity assay as well as the in vitro oxidation of low density lipoproteins with the conjugated diene and the thiobarbituric acid reacting substances formation as end points were used. The oxidative metabolites of genistein and daidzein as well as equol exhibited the highest antioxidant activities in all three assays. With few exceptions, they were more effective than the positive controls quercetin and ascorbic acid. Formononetin, the 4'-O-methyl ether of daidzein, showed the lowest antioxidant property. Because the antioxidant efficacy of isoflavones as effective antioxidants is evident at concentrations well within the range found in the plasma of subjects consuming soy products, this biological activity could be of physiological relevance.

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Research works printed but not linked: 13

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Metadata

Authors
Rüfer, C. E., & Kulling, S. E.
Venue
Journal of Agricultural and Food Chemistry
Publisher
American Chemical Society (ACS)
Published
2006-03-18
Volume
54
Issue
8
Pages
2926-2931
ISSN
  • 0021-8561 (ISSN-L)
  • 1520-5118
DOI
10.1021/jf053112o
OpenAlex
W1972943340
Cited by
321
References
16
FWCI
15.41
Type
journal article
Language
en
Open access
closed

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