The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Inhibition of Key Digestive Enzymes by Cocoa Extracts and Procyanidins
Open accessAbstract
This study determined the in vitro inhibitory effects of cocoa extracts and procyanidins against pancreatic α-amylase (PA), pancreatic lipase (PL), and secreted phospholipase A(2) (PLA(2)) and characterized the kinetics of such inhibition. Lavado, regular, and Dutch-processed cocoa extracts as well as cocoa procyanidins (degree of polymerization (DP) = 2-10) were examined. Cocoa extracts and procyanidins dose-dependently inhibited PA, PL, and PLA(2). Lavado cocoa extract was the most potent inhibitor (IC(50) = 8.5-47 μg/mL). An inverse correlation between log IC(50) and DP (R(2) > 0.93) was observed. Kinetic analysis suggested that regular cocoa extract, the pentamer, and decamer inhibited PL activity in a mixed mode. The pentamer and decamer noncompetitively inhibited PLA(2) activity, whereas regular cocoa extract inhibited PLA(2) competitively. This study demonstrates that cocoa polyphenols can inhibit digestive enzymes in vitro and may, in conjunction with a low-calorie diet, play a role in body weight management.
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Cites
Increased oxidative stress in obesity and its impact on metabolic syndrome
Furukawa, S., Fujita, T., Shimabukuro, M., Iwaki, M., Yamada, Y., Nakajima, Y., Nakayama, O., Makishima, M., Matsuda, M., & Shimomura, I. (2004) · Journal of Clinical Investigation · doi:10.1172/jci21625 · Cited by 5,508
(–)-Epicatechin mediates beneficial effects of flavanol-rich cocoa on vascular function in humans
Schroeter, H., Heiss, C., Balzer, J., Kleinbongard, P., Keen, C. L., Hollenberg, N. K., Sies, H., Kwik-Uribe, C., Schmitz, H. H., & Kelm, M. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0510168103 · Cited by 1,052
Hammerstone, J. F., Lazarus, S. A., Mitchell, A. E., Rucker, R., & Schmitz, H. H. (1999) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf980760h · Cited by 455
Cited by
Podsędek, A., Majewska, I., Redzynia, M., Sosnowska, D., & Koziołkiewicz, M. (2014) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf5008264 · Cited by 266
Ong, S. L., Mah, S. H., & Lai, H. Y. (2016) · Journal of Pharmaceutics · doi:10.1155/2016/8764274 · Cited by 26
Metadata
- Authors
- Gu, Y., Hurst, W. J., Stuart, D. A., & Lambert, J. D.
- Venue
- Journal of Agricultural and Food Chemistry
- Publisher
- American Chemical Society (ACS)
- Published
- 2011-04-26
- Volume
- 59
- Issue
- 10
- Pages
- 5305-5311
- ISSN
- 0021-8561 (ISSN-L)
- 1520-5118
- OpenAlex
- W2072983925
- Cited by
- 190
- References
- 3
- FWCI
- 16.19
- Type
- journal article
- Language
- en
- Open access
- green
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- Gu, Y., Hurst, W. J., Stuart, D. A., & Lambert, J. D. (2011). Inhibition of Key Digestive Enzymes by Cocoa Extracts and Procyanidins. Journal of Agricultural and Food Chemistry. https://doi.org/10.1021/jf200180n
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