Cited by 49Fatty Acid Research and HealthDiet, Metabolism, and DiseaseLipid metabolism and biosynthesis

Beneficial Effects of Dietary Fish-Oil-Derived Monounsaturated Fatty Acids on Metabolic Syndrome Risk Factors and Insulin Resistance in Mice

Yang, Zhi-Hong, Miyahara, Hiroko, Mori, Tetsu, Doisaki, Nobushige, Hatanaka, Akimasa·2011·Journal of Agricultural and Food Chemistry

Abstract

The aim of this study was to elucidate the effect of fish-oil-derived monounsaturated fatty acids (MUFAs) containing large amounts of C20:1 and C22:1 isomers on metabolic disorders in mice. Male C57BL/6J mice were fed a 32% lard diet (control) or a 27% lard plus 5% saury-oil-derived MUFA diet for 6 weeks. Dietary MUFA improved insulin resistance and alleviated metabolic syndrome risk factors by reducing blood glucose and lipids. These favorable changes may be attributed to an improved adipocytokine profile. MUFA ingestion resulted in favorable changes in mRNA expression of genes involved in glucose/lipid metabolism (SCD-1, CPT1a, UCPs, and CS) as well as inflammation (MAC1, MMP3, and SAA3) and alterations in fatty acid composition. Our data suggest that marine MUFA improved glucose/lipid homeostasis and hindered the development of metabolic syndrome in obese mice.

Integrity signals

Registry

Crossref · 10.1021/jf201496h

Cites

31 of 31 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Cites

Flagged first, then by citations

2 of the 33 references couldn’t be matched to a known paper.

Cited by

Sorted by citations

Authors
Yang, Z.-H., Miyahara, H., Mori, T., Doisaki, N., & Hatanaka, A.
Affiliations
  • Central Research Laboratory, Tokyo Innovation Center, Nippon Suisan Kaisha, Ltd., 32-3 Nanakuni 1 Chome Hachioji, Tokyo 192-0991, Japan
  • Nippon Suisan Kaisha (Japan) (JP)
Venue
Journal of Agricultural and Food Chemistry
Published
2011-06-10
Volume
59
Issue
13
Pages
7482-7489
ISSN
  • 0021-8561 (ISSN-L)
  • 1520-5118
OpenAlex
W2050873784
Cited by
49
References
33
Citations by year
2026: 2 · 2025: 3 · 2023: 1 · 2022: 5 · 2021: 2 · 2020: 3 · 2019: 2 · 2018: 3 · 2017: 4 · 2016: 3 · 2015: 7 · 2014: 5 · 2013: 3 · 2012: 4
FWCI
4.14
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of Agricultural and Food Chemistry (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Agilent Technologies
  • Otsuka Pharmaceutical
Topics
  • Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diet, Metabolism, and Disease
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
Keywords
metabolic syndrome, insulin resistance, adipokines, stearoyl-CoA desaturase 1, CPT1A, uncoupling proteins, inflammation, fatty acid composition, obesity, C57BL/6J mice
MeSH terms
Animals, Blood Glucose, Dietary Fats, Dietary Fats, Unsaturated, Fatty Acids, Monounsaturated, Fish Oils, Insulin Resistance, Lipid A, Male, Mice, Inbred C57BL, Obesity, Metabolic Syndrome, Mice

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review