Macrophages in human visceral adipose tissue: increased accumulation in obesity and a source of resistin and visfatin
Open accessAbstract
Aims/hypothesis Increased visceral white adipose tissue (WAT) is linked to the risk of developing diabetes.Methods/results We showed by fluorescence activated cell sorting analysis that human visceral WAT contains macrophages, the proportion of which increased with obesity. Selective isolation of mature adipocytes and macrophages from human visceral WAT by CD14 immunoselection revealed that macrophages expressed higher levels of chemokines (monocyte chemotactic protein 1, macrophage inflammatory protein 1alpha, IL-8) and the adipokines resistin and visfatin than did mature adipocytes, as assessed by real-time PCR analysis. Moreover, resistin and visfatin proteins were found to be released predominantly by visceral WAT macrophages. Macrophage-derived secretory products stimulated phosphorylation of protein kinase B in human hepatocytes.Conclusions/interpretation Resistin and visfatin might be considered to be proinflammatory markers. The increased macrophage population in obese human visceral WAT might be responsible for the enhanced production of chemokines as well as resistin and visfatin.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
TNF-a infusion into rodents impairs insulin signalling in vivo.
“The impairment of insulin signalling by TNF-a has also been observed in vivo after infusion of the cytokine into rodents (133,134) .”
From Dietary factors and low-grade inflammation in relation to overweight and obesity (2011) · cites this paper as [134]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
1 retracted
Visfatin: A Protein Secreted by Visceral Fat That Mimics the Effects of Insulin
Fukuhara, A., Matsuda, M., Nishizawa, M., Segawa, K., Tanaka, M., Kishimoto, K., Matsuki, Y., Murakami, M., Ichisaka, T., Murakami, H., et al. (2005) · Science · doi:10.1126/science.1097243 · Cited by 1,906 · see citing works
RetractedObesity is associated with macrophage accumulation in adipose tissue
Weisberg, S. P., McCann, D., Desai, M., Rosenbaum, M., Leibel, R. L., & Ferrante, A. W. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200319246 · Cited by 10,041 · see citing works
Adipokines: inflammation and the pleiotropic role of white adipose tissue
Trayhurn, P., & Wood, I. S. (2004) · British Journal of Nutrition · doi:10.1079/bjn20041213 · Cited by 2,210 · see citing works
Resistin Is an Inflammatory Marker of Atherosclerosis in Humans
Reilly, M. P., Lehrke, M., Wolfe, M. L., Rohatgi, A. K., Lazar, M. A., & Rader, D. J. (2005) · Circulation · doi:10.1161/01.cir.0000155620.10387.43 · Cited by 909 · see citing works
Jia, S. H., Li, Y., Parodo, J. C., Kapùs, A., Fan, L., Rotstein, O. D., & Marshall, J. C. (2004) · Journal of Clinical Investigation · doi:10.1172/jci19930 · Cited by 609 · see citing works
From Blood Monocytes to Adipose Tissue-Resident Macrophages
Curat, C. A., Miranville, A., Sengenès, C., Diehl, M., Tonus, C., Busse, R., & Bouloumié, A. (2004) · Diabetes · doi:10.2337/diabetes.53.5.1285 · Cited by 600 · see citing works
Self-citationAn Inflammatory Cascade Leading to Hyperresistinemia in Humans
Lehrke, M., Reilly, M. P., Millington, S. C., Iqbal, N., Rader, D. J., & Lazar, M. A. (2004) · PLoS Medicine · doi:10.1371/journal.pmed.0010045 · Cited by 523 · see citing works
Role of resistin in diet-induced hepatic insulin resistance
Muse, E. D., Obici, S., Bhanot, S., Monia, B. P., McKay, R. A., Rajala, M. W., Scherer, P. E., & Rossetti, L. (2004) · Journal of Clinical Investigation · doi:10.1172/jci21270 · Cited by 371 · see citing works
Role of macrophage tissue infiltration in metabolic diseases
Bouloumié, A., Curat, C. A., Sengenès, C., Lolmède, K., Miranville, A., & Busse, R. (2005) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/01.mco.0000172571.41149.52 · Cited by 262 · see citing works
Self-citationSengenès, C., Lolmède, K., Zakaroff‐Girard, A., Busse, R., & Bouloumié, A. (2005) · Journal of Cellular Physiology · doi:10.1002/jcp.20381 · Cited by 250 · see citing works
Self-citationRuan, H., Zarnowski, M. J., Cushman, S. W., & Lodish, H. F. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m305257200 · Cited by 168 · see citing works
Nair, S., Lee, Y. H., Rousseau, E., Cam, M. C., Tataranni, P. A., Baier, L. J., Bogardus, C., & Permana, P. A. (2005) · Diabetologia · doi:10.1007/s00125-005-1868-2 · Cited by 141 · see citing works
The relationship of obesity to the metabolic syndrome.
Lebovitz, H. E. (2003) · PubMed · Cited by 103 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Subcutaneous and visceral adipose tissue: Structural and functional differences
Ibrahim, M. M. (2010) · Obesity Reviews · doi:10.1111/j.1467-789x.2009.00623.x · Cited by 2,238 · see citing works
Adipose tissue inflammation and metabolic dysfunction in obesity
Kawai, T., Autieri, M. V., & Scalia, R. (2021) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00379.2020 · Cited by 1,947 · see citing works
Dietary factors and low-grade inflammation in relation to overweight and obesity
Calder, P. C., Ahluwalia, N., Brouns, F., Buetler, T., Clement, K., Cunningham, K., Esposito, K., Jönsson, L. S., Kolb, H., Lansink, M., et al. (2011) · British Journal of Nutrition · doi:10.1017/s0007114511005460 · Cited by 1,098 · see citing works
Nguyen, M. T. A., Favelyukis, S., Nguyen, A.-K., Reichart, D., Scott, P. A., Jenn, A., Liu-Bryan, R., Glass, C. K., Neels, J. G., & Olefsky, J. M. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m706762200 · Cited by 1,035 · see citing works
Physiological and pathophysiological roles of NAMPT and NAD metabolism.
Garten, A., Schuster, S., Penke, M., Gorski, T., de Giorgis, T., & Kiess, W. (2015) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2015.117 · Cited by 708 · see citing works
The role of adipose tissue dysfunction in the pathogenesis of obesity-related insulin resistance
Goossens, G. H. (2008) · Physiology & Behavior · doi:10.1016/j.physbeh.2007.10.010 · Cited by 591 · see citing works
The role of adipokines in health and disease
Clemente-Suárez, V. J., Redondo-Flórez, L., Beltrán-Velasco, A. I., Martín-Rodríguez, A., Martínez-Guardado, I., Navarro-Jiménez, E., Laborde-Cárdenas, C. C., & Tornero-Aguilera, J. F. (2023) · Biomedicines · doi:10.3390/biomedicines11051290 · Cited by 463 · see citing works
Lacasa, D., Taleb, S., Keophiphath, M., Miranville, A., & Clement, K. (2007) · Endocrinology · doi:10.1210/en.2006-0687 · Cited by 334 · see citing works
Self-citationKabir, M., Skurnik, G., Naour, N., Pechtner, V., Meugnier, E., Rome, S., Quignard-Boulangé, A., Vidal, H., Slama, G., Clément, K., et al. (2007) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/86.5.1670 · Cited by 316 · see citing works
The role of adipokines in inflammatory mechanisms of obesity
Kirichenko, T. V., Markina, Y. V., Bogatyreva, A. I., Tolstik, T. V., Varaeva, Y. R., & Starodubova, A. V. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232314982 · Cited by 289 · see citing works
The infrapatellar fat pad of patients with osteoarthritis has an inflammatory phenotype
Klein-Wieringa, I. R., Kloppenburg, M., Bastiaansen-Jenniskens, Y. M., Yusuf, E., Kwekkeboom, J. C., El-Bannoudi, H., Nelissen, R. G. H. H., Zuurmond, A., Stojanovic-Susulic, V, Van Osch, G. J. V. M., et al. (2011) · Annals of the Rheumatic Diseases · doi:10.1136/ard.2010.140046 · Cited by 289 · see citing works
Associations of Adiponectin, Resistin, and Tumor Necrosis Factor-α with Insulin Resistance
Hivert, M.-F., Sullivan, L. M., Fox, C. S., Nathan, D. M., D’Agostino, R. B., Wilson, P. W. F., & Meigs, J. B. (2008) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2008-0425 · Cited by 262 · see citing works
Plasminogen activator inhibitor-1, adipose tissue and insulin resistance
Alessi, M.-C., Poggi, M., & Juhan-Vague, I. (2007) · Current Opinion in Lipidology · doi:10.1097/mol.0b013e32814e6d29 · Cited by 212 · see citing works
Obesity and weight gain in persons with HIV
Bailin, S. S., Gabriel, C. L., Wanjalla, C. N., & Koethe, J. R. (2020) · Current HIV/AIDS Reports · doi:10.1007/s11904-020-00483-5 · Cited by 213 · see citing works
Contribution of adipose tissue to development of cancer
Cozzo, A. J., Fuller, A. M., & Makowski, L. (2017) · Comprehensive Physiology · doi:10.1002/cphy.c170008 · Cited by 188 · see citing works
Characterization of Distinct Subpopulations of Hepatic Macrophages in HFD/Obese Mice
Morinaga, H., Mayoral, R., Heinrichsdorff, J., Osborn, O., Franck, N., Hah, N., Walenta, E., Bandyopadhyay, G., Pessentheiner, A. R., Chi, T. J., et al. (2015) · Diabetes · doi:10.2337/db14-1238 · Cited by 175 · see citing works
Impact of visceral adipose tissue on liver metabolism
Lafontan, M., & Girard, J. (2008) · Diabetes & Metabolism · doi:10.1016/j.diabet.2008.04.001 · Cited by 143 · see citing works
From PDE3B to the regulation of energy homeostasis
Degerman, E., Ahmad, F., Chung, Y. W., Guirguis, E., Omar, B., Stenson, L., & Manganiello, V. (2011) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2011.09.015 · Cited by 130 · see citing works
O’Hara, A., Lim, F.-L., Mazzatti, D. J., & Trayhurn, P. (2009) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-009-0693-8 · Cited by 108 · see citing works
Regulation of inflammation-related genes in human adipose tissue
Clement, K., & Langin, D. (2007) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.2007.01851.x · Cited by 98 · see citing works
The pathophysiology of abdominal adipose tissue depots in health and disease
Walker, G. E., Marzullo, P., Ricotti, R., Bona, G., & Prodam, F. (2014) · Hormone Molecular Biology and Clinical Investigation · doi:10.1515/hmbci-2014-0023 · Cited by 90 · see citing works
Exercise Interventions and Peripheral Arterial Function: Implications for Cardio-Metabolic Disease
Phillips, S. A., Mahmoud, A. M., Brown, M. D., & Haus, J. M. (2015) · Progress in Cardiovascular Diseases · doi:10.1016/j.pcad.2014.12.005 · Cited by 78 · see citing works
Obesity associated disease risk: the role of inherent differences and location of adipose depots
Hill, J. H., Solt, C., & Foster, M. T. (2018) · Hormone Molecular Biology and Clinical Investigation · doi:10.1515/hmbci-2018-0012 · Cited by 79 · see citing works
Martos-Moreno, G. Á., Kratzsch, J., Körner, A., Barrios, V, Hawkins, F., Kiess, W., & Argente, J. (2011) · International Journal of Obesity · doi:10.1038/ijo.2010.280 · Cited by 58 · see citing works
Yang, Z.-H., Miyahara, H., Mori, T., Doisaki, N., & Hatanaka, A. (2011) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf201496h · Cited by 49 · see citing works
Ghaffari, M. A., Mousavinejad, E., Riahi, F., Mousavinejad, M., & Afsharmanesh, M. R. (2016) · Neurology Research International · doi:10.1155/2016/9060751 · Cited by 49 · see citing works
Adipocytokines: a bridge connecting obesity and insulin resistance
Zhuang, X.-F., Zhao, M.-M., Weng, C.-L., & Sun, N.-L. (2009) · Medical Hypotheses · doi:10.1016/j.mehy.2009.05.036 · Cited by 41 · see citing works
- Authors
- Curat, C. A., Wegner, V., Sengenès, C., Miranville, A., Tonus, C., Busse, R., & Bouloumié, A.
- Affiliations
- Goethe University Frankfurt (DE)
- Sana Klinikum Offenbach (DE)
- Corresponding author
- Bouloumié, A.
- Venue
- Diabetologia
- Published
- 2006-02-23
- Volume
- 49
- Issue
- 4
- Pages
- 744-747
- ISSN
- 0012-186X (ISSN-L)
- 1432-0428
- OpenAlex
- W2077745556
- Cited by
- 693
- References
- 13
- Citations by year
- 2026: 5 · 2025: 13 · 2024: 17 · 2023: 19 · 2022: 31 · 2021: 24 · 2020: 28 · 2019: 27 · 2018: 37 · 2017: 39 · 2016: 35 · 2015: 32 · 2014: 39 · 2013: 43 · 2012: 35
- FWCI
- 41.00
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Diabetologia (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Alexander von Humboldt-Stiftung
- Bundesministerium für Bildung und Forschung
- Topics
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
- Keywords
- macrophages, visceral adipose tissue, obesity, resistin, visfatin, adipokines, chemokines, MCP-1, macrophage inflammatory protein-1alpha, interleukin-8, adipocytes, Akt, hepatocytes, inflammation, diabetes risk
- MeSH terms
- Adult, Aged, Aged, 80 and over, Cell Movement, Female, Humans, Macrophages, Male, Middle Aged, Obesity, Cytokines, Lipopolysaccharide Receptors, Hepatocytes, Abdominal Fat, Resistin, Nicotinamide Phosphoribosyltransferase
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
