Cited by 66Skin Protection and AgingProtein Hydrolysis and Bioactive PeptidesCollagen: Extraction and Characterization

The effect of collagen hydrolysates from silver carp (Hypophthalmichthys molitrix) skin on UV-induced photoaging in mice: Molecular weight affects skin repair

Song, Hongdong, Meng, Mengfei, Cheng, Xiaofeng, Li, Bo, Wang, Chengtao·2017·Food & Function

Abstract

The use of collagen hydrolysates (CHs) as a nutraceutical agent in skin aging has gained increasing attention. Here, the effects of various doses and molecular weights of CH from silver carp skin on photoaging in mice were investigated. The ingestion of CH at 50, 100 and 200 mg per kg body weight led to a dose-dependent increase in the hydroxyproline, hyaluronic acid and moisture contents of the skin, but it had no significant effect on the mice body weight, or on the spleen or thymus index. Furthermore, ingesting CH with lower (LMCH, 200-1000 Da, 65%) and higher molecular weight (HMCH, >1000 Da, 72%) significantly increased the skin components and improved the antioxidative enzyme activities in both serum and skin (p < 0.05); LMCH performed better than HMCH. By contrast, gelatin (>120 kDa) ingestion did not bring a significant change compared to model mice. These results indicated that LMCH exerted a stronger beneficial effect on the skin than did either HMCH and gelatin, which supported the feasibility of using LMCH as a dietary supplement from silver carp skin to combat photoaging.

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Crossref · 10.1039/c6fo01397j

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48 of 48 references verified0 citation errors · 0 not checkable

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  • Mounting evidence from animal models and clinical trials suggests that various food-derived components attenuate the development and symptoms of skin photoaging.

    “mounting evidence from animal models and clinical trials suggests that various food-derived components attenuate the development and symptoms of skin photoaging”
  • There is increasing animal and clinical evidence that dietary supplementation of functional components can protect skin from photoaging damage.

    “There is increasing animal and clinical evidence that dietary supplementation of functional components can protect skin from photoaging damage.”
  • Phytochemicals, functional proteins and peptides, functional sugars, functional oils, probiotics, vitamins, and minerals improve photoaging-associated morphological abnormalities and functional decline.

    “Phytochemicals [8], functional proteins [9] and peptides [10], functional sugars [11,12], functional oils [13], probiotics [14,15], vitamins [16,17], and minerals [18,19] are well-known to improve the photoaging-associated morphological abnormalities and functional decline.”
  • Oral administration of collagen hydrolysate from silver carp skin ameliorated skin photoaging in mice.

    “Oral administration of collagen hydrolysate from silver carp (Hypophthalmichthys molitrix) skin ameliorated skin photoaging in mice.”
  • Ingesting collagen hydrolysate with lower (200-1000 Da, 65%) and higher molecular weight (>1000 Da, 72%) markedly improved antioxidative enzyme activities in both serum and skin of Kunming mice.

    “Moreover, ingesting collagen hydrolysate with lower (200–1000 Da, 65%) and higher molecular weight (>1000 Da, 72%) markedly improved the antioxidative enzyme activities in both serum and skin of Kunming mice [10].”

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Authors
Song, H., Meng, M., Cheng, X., Li, B., & Wang, C.
Affiliations
  • China Agricultural University (CN)
  • College of Food Science and Nutritional Engineering
  • Beijing Technology and Business University (CN)
Corresponding author
Wang, Chengtao
Venue
Food & Function
Published
2017
Volume
8
Issue
4
Pages
1538-1546
ISSN
  • 2042-6496 (ISSN-L)
  • 2042-650X
OpenAlex
W2587262511
Cited by
66
References
48
Citations by year
2026: 6 · 2025: 9 · 2024: 4 · 2023: 5 · 2022: 8 · 2021: 9 · 2020: 6 · 2019: 10 · 2018: 7 · 2017: 2
FWCI
7.77
Type
journal article
Language
en
Open access
closed
Locations
  • Food & Function (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Dermatology › Skin Protection and Aging
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Hydrolysis and Bioactive Peptides
  • Physical Sciences › Materials Science › Biomaterials › Collagen: Extraction and Characterization
Keywords
collagen peptides, silver carp, photoaging, UV-induced skin damage, molecular weight, skin repair, nutraceuticals, dietary supplementation, antioxidant enzymes, hyaluronic acid, hydroxyproline, skin hydration, gelatin
MeSH terms
Animals, Carps, Collagen, Female, Humans, Molecular Weight, Skin, Ultraviolet Rays, Skin Aging, Fish Proteins, Mice

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