Cited by 24Proteoglycans and glycosaminoglycans researchSeaweed-derived Bioactive CompoundsInflammatory mediators and NSAID effects

Chondroitin sulfate extracted from ascidian tunic inhibits phorbol ester-induced expression of inflammatory factors VCAM-1 and COX-2 by blocking NF-κB activation in mouse skin

Xu, Cheng-Xiong, Jin, Hua, Chung, Youn-Sun, Shin, Ji-Young, Lee, Kee-Ho, Beck, George R., Palmos, Grace N., Choi, Byeong-Dae +1 more·2008·Journal of Agricultural and Food Chemistry

Abstract

Inflammatory factors are known to play a key role in promoting tumorigenesis; therefore, it is a promising strategy to inhibit the inflammation for cancer prevention. The current study was performed to investigate the potential effects of chondroitin sulfate (CS) extracted from ascidian tunic on the expression of inflammatory factors induced by treatment with 12- O-tetradecanoylphorbol-13-acetate (TPA) and to elucidate the underlying molecular mechanism of CS action in mouse skin inflammation. TPA was topically applied to the shaven backs of ICR mice with or without CS (1 or 2 mg) for 4 h. The results demonstrated that CS suppressed TPA-induced edema and reduced the expression of cyclooxygenase-2, vascular cell adhesion molecule-1, and Akt signaling in mouse skin. These studies suggest that CS from ascidian tunic may be developed as an effective natural anti-inflammatory agent.

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Crossref · 10.1021/jf801578x

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  • Chondroitin sulfate isolated from ascidian Styela clava inhibited phorbol ester- and TNF-α-induced expression of inflammatory factors VCAM-1, COX-2 and iNOS by blocking Akt/NF-κB activation in mouse skin.

    “Chondroitin sulfate isolated from ascidian Styela clava inhibited phorbol ester- and TNF-α-induced expression of inflammatory factors VCAM-1, COX-2 and iNOS by blocking Akt/NF-κB activation in mouse skin [154,155].”

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Authors
Xu, C.-X., Jin, H., Chung, Y.-S., Shin, J.-Y., Lee, K.-H., Beck, G. R., Palmos, G. N., Choi, B.-D., & Cho, M.-H.
Affiliations
  • Seoul National University (KR)
  • Laboratory of Toxicology, College of Veterinary Medicine, and Nano Systems Institute, National Core Research Center, Seoul National University, Seoul 151-742, Korea; Laboratory of Molecular Oncology, Korea Institute of Radiological and Medical Sciences, Seoul 139-240, Korea; Division of Endocrinology, Metabolism and Lipids, Emory University School of Medicine, Atlanta, Georgia 30322; Division of Marine Life Science/Institute of Marine Industry, Gyeongsang National University, Tongyoung 650-160, Korea;...
Corresponding author
  • Choi, Byeong-Dae
  • Cho, Myung-Haing
Venue
Journal of Agricultural and Food Chemistry
Published
2008-09-19
Volume
56
Issue
20
Pages
9667-9675
ISSN
  • 0021-8561 (ISSN-L)
  • 1520-5118
OpenAlex
W2041356412
Cited by
24
References
30
Citations by year
2026: 1 · 2022: 2 · 2021: 2 · 2018: 1 · 2016: 1 · 2014: 5 · 2013: 4 · 2012: 4
FWCI
0.58
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of Agricultural and Food Chemistry (publishedVersion)
  • PubMed (publishedVersion)
  • Seoul National University Open Repository (Seoul National University) (submittedVersion)
Funders
National Cancer Institute (CA 84573, K22CA084573)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Proteoglycans and glycosaminoglycans research
  • Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Seaweed-derived Bioactive Compounds
  • Health Sciences › Medicine › Pharmacology › Inflammatory mediators and NSAID effects
Keywords
chondroitin sulfate, anti-inflammatory activity, NF-κB activation, VCAM-1, cyclooxygenase-2, phorbol myristate acetate, skin inflammation, edema, Akt signaling, cancer prevention
MeSH terms
Animals, Carcinogens, Cell Extracts, Chondroitin Sulfates, Female, Humans, Inflammation, Mice, Inbred ICR, Phorbol Esters, Phosphorylation, Random Allocation, Skin, Urochordata, Signal Transduction, Down-Regulation, Gene Expression, NF-kappa B, Vascular Cell Adhesion Molecule-1, Mice, Cyclooxygenase 2

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