The DOI matches its Crossref record; 37 of the 37 references it cites were found in a registry or an index.
Relationship between the Antioxidant Capacity and Effect of Rosemary (Rosmarinus officinalis L.) Polyphenols on Membrane Phospholipid Order
Abstract
The antioxidant activity of rosemary (Rosmarinus officinalis L.) extracts is mainly due to phenolic abietane diterpenes and phenolic acids such as rosmarinic acid. In this study a comprehensive characterization of non-water-soluble and water-soluble extracts from rosemary was achieved by liquid chromatography coupled to electrospray and mass spectrometry. The antioxidant activity of these extracts and their respective major compounds (carnosic acid, carnosol, rosmadial, genkwanin, and rosmarinic acid) was analyzed and compared by using different in vitro systems. Whereas rosmarinic acid, carnosic acid, and carnosol exhibited similar antioxidant activity in a phospholipid membrane-free assay, carnosol behaved as an extremely potent antioxidant in a membrane-based assay (4-6 times stronger than the rest of the compounds). This differential antioxidant behavior suggests that factors other than the radical scavenging capability may be involved. All of the diterpenes induced severe effects on lipid order and packing of phospholipid model membranes. Rosmadial and carnosol decreased the number and/or mobility of water molecules located at the polar head group region of the membrane phospholipids as seen by Laurdan fluorescence spectroscopy. Carnosol also strongly enhanced lipid order at the hydrophobic core of the membrane. These effects throughout the bilayer correlated to the stronger antioxidant capacity of carnosol to inhibit lipid peroxidation. On the contrary, carnosic acid decreased membrane fluidity at deeper regions of the bilayer as measured by bilayer-to-micelle transition assay and self-quenching measurements by using octadecylrhodamine B. These effects may contribute to membrane stabilization and hindrance of radical propagation, which may cooperate with the electron donor ability of rosemary diterpenes in protecting the membranes against oxidative damage.
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Cites
Antioxidant activity applying an improved ABTS radical cation decolorization assay
Re, R., Pellegrini, N., Proteggente, A., Pannala, A., Yang, M., & Rice-Evans, C. (1999) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(98)00315-3 · Cited by 26,165
Prior, R. L., Wu, X., & Schaich, K. (2005) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf0502698 · Cited by 5,650
Principles of Fluorescence Spectroscopy
Lakowicz, J. R. (1983) · Springer eBooks · doi:10.1007/978-1-4615-7658-7 · Cited by 5,014
Antioxidant Activity and Phenolic Compounds in Selected Herbs
Zheng, W., & Wang, S. Y. (2001) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf010697n · Cited by 2,883
The Pecking Order of Free Radicals and Antioxidants: Lipid Peroxidation, α-Tocopherol, and Ascorbate
Buettner, G. R. (1993) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.1993.1074 · Cited by 2,417
Effects of antioxidant enzymes in the molecular control of reactive oxygen species toxicology
Matés, >. M. (2000) · Toxicology · doi:10.1016/s0300-483x(00)00306-1 · Cited by 1,518
Techniques of flavonoid identification:
Wollenweber, E. (1983) · Phytochemistry · doi:10.1016/0031-9422(83)80259-3 · Cited by 1,172
Parasassi, T., De Stasio, G., Ravagnan, G., Rusch, R. M., & Gratton, E. (1991) · Biophysical Journal · doi:10.1016/s0006-3495(91)82041-0 · Cited by 902
Carotenoids as membrane stabilizers in chloroplasts
Havaux, M. (1998) · Trends in Plant Science · doi:10.1016/s1360-1385(98)01200-x · Cited by 683
Modulation of Liposomal Membrane Fluidity by Flavonoids and Isoflavonoids
Arora, A., Byrem, T. M., Nair, M. G., & Strasburg, G. M. (2000) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.1999.1525 · Cited by 594
Cited by
Diniz do Nascimento, L., Moraes, A. A. B. D., Costa, K. S. D., Pereira Galúcio, J. M., Taube, P. S., Costa, C. M. L., Neves Cruz, J., de Aguiar Andrade, E. H., & Faria, L. J. G. D. (2020) · Biomolecules · doi:10.3390/biom10070988 · Cited by 470
Medicinal Plants of the Family Lamiaceae in Pain Therapy: A Review
Uritu, C. M., Mihai, C. T., Stanciu, G.-D., Dodi, G., Alexa-Stratulat, T., Luca, A., Leon-Constantin, M.-M., Stefanescu, R., Bild, V., Melnic, S., et al. (2018) · Pain Research and Management · doi:10.1155/2018/7801543 · Cited by 367
Rosmarinus officinalis L. (rosemary) as therapeutic and prophylactic agent
de Oliveira, J. R., Camargo, S. E. A., & de Oliveira, L. D. (2019) · Journal of Biomedical Science · doi:10.1186/s12929-019-0499-8 · Cited by 367
Rosmarinus officinalis L.: an update review of its phytochemistry and biological activity
Andrade, J. M., Faustino, C., Garcia, C., Ladeiras, D., Reis, C. P., & Rijo, P. (2018) · Future Science OA · doi:10.4155/fsoa-2017-0124 · Cited by 357
Mena, P., Cirlini, M., Tassotti, M., Herrlinger, K., Dall’Asta, C., & Del Rio, D. (2016) · Molecules · doi:10.3390/molecules21111576 · Cited by 288
Carnosic Acid and Carnosol, Two Major Antioxidants of Rosemary, Act through Different Mechanisms
Loussouarn, M., Krieger-Liszkay, A., Svilar, L., Bily, A., Birtić, S., & Havaux, M. (2017) · PLANT PHYSIOLOGY · doi:10.1104/pp.17.01183 · Cited by 234
Jardak, M., Elloumi-Mseddi, J., Aifa, S., & Mnif, S. (2017) · Lipids in Health and Disease · doi:10.1186/s12944-017-0580-9 · Cited by 119
Nobile, V., Michelotti, A., Cestone, E., Caturla, N., Castillo, J., Benavente-García, O., Pérez-Sánchez, A., & Micol, V. (2016) · Food & Nutrition Research · doi:10.3402/fnr.v60.31871 · Cited by 56
Self-citationde Oliveira Bispo, M., Morocho-Jácome, A. L., Escudeiro, C. C., Martinez, R. M., de Oliveira Pinto, C. A. S., Rosado, C., Velasco, M. V. R., & Baby, A. R. (2023) · Cosmetics · doi:10.3390/cosmetics10010011 · Cited by 13
Metadata
- Authors
- Pérez-Fons, L., GarzÓn, M. T., & Micol, V.
- Venue
- Journal of Agricultural and Food Chemistry
- Publisher
- American Chemical Society (ACS)
- Published
- 2009-11-19
- Volume
- 58
- Issue
- 1
- Pages
- 161-171
- ISSN
- 0021-8561 (ISSN-L)
- 1520-5118
- OpenAlex
- W1987370786
- Cited by
- 273
- References
- 37
- FWCI
- 6.17
- Type
- journal article
- Language
- en
- Open access
- closed
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