The DOI matches its Crossref record; 37 of the 37 references it cites were found in a registry or an index.
Relationship between the Antioxidant Capacity and Effect of Rosemary (Rosmarinus officinalis L.) Polyphenols on Membrane Phospholipid Order
Abstract
The antioxidant activity of rosemary (Rosmarinus officinalis L.) extracts is mainly due to phenolic abietane diterpenes and phenolic acids such as rosmarinic acid. In this study a comprehensive characterization of non-water-soluble and water-soluble extracts from rosemary was achieved by liquid chromatography coupled to electrospray and mass spectrometry. The antioxidant activity of these extracts and their respective major compounds (carnosic acid, carnosol, rosmadial, genkwanin, and rosmarinic acid) was analyzed and compared by using different in vitro systems. Whereas rosmarinic acid, carnosic acid, and carnosol exhibited similar antioxidant activity in a phospholipid membrane-free assay, carnosol behaved as an extremely potent antioxidant in a membrane-based assay (4-6 times stronger than the rest of the compounds). This differential antioxidant behavior suggests that factors other than the radical scavenging capability may be involved. All of the diterpenes induced severe effects on lipid order and packing of phospholipid model membranes. Rosmadial and carnosol decreased the number and/or mobility of water molecules located at the polar head group region of the membrane phospholipids as seen by Laurdan fluorescence spectroscopy. Carnosol also strongly enhanced lipid order at the hydrophobic core of the membrane. These effects throughout the bilayer correlated to the stronger antioxidant capacity of carnosol to inhibit lipid peroxidation. On the contrary, carnosic acid decreased membrane fluidity at deeper regions of the bilayer as measured by bilayer-to-micelle transition assay and self-quenching measurements by using octadecylrhodamine B. These effects may contribute to membrane stabilization and hindrance of radical propagation, which may cooperate with the electron donor ability of rosemary diterpenes in protecting the membranes against oxidative damage.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Antioxidant activity applying an improved ABTS radical cation decolorization assay
Re, R., Pellegrini, N., Proteggente, A., Pannala, A., Yang, M., & Rice-Evans, C. (1999) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(98)00315-3 · Cited by 26,165
Prior, R. L., Wu, X., & Schaich, K. (2005) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf0502698 · Cited by 5,650
Principles of Fluorescence Spectroscopy
Lakowicz, J. R. (1983) · Springer eBooks · doi:10.1007/978-1-4615-7658-7 · Cited by 5,014
Antioxidant Activity and Phenolic Compounds in Selected Herbs
Zheng, W., & Wang, S. Y. (2001) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf010697n · Cited by 2,883
The Pecking Order of Free Radicals and Antioxidants: Lipid Peroxidation, α-Tocopherol, and Ascorbate
Buettner, G. R. (1993) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.1993.1074 · Cited by 2,417
Effects of antioxidant enzymes in the molecular control of reactive oxygen species toxicology
Matés, >. M. (2000) · Toxicology · doi:10.1016/s0300-483x(00)00306-1 · Cited by 1,518
Techniques of flavonoid identification:
Wollenweber, E. (1983) · Phytochemistry · doi:10.1016/0031-9422(83)80259-3 · Cited by 1,172
Parasassi, T., De Stasio, G., Ravagnan, G., Rusch, R. M., & Gratton, E. (1991) · Biophysical Journal · doi:10.1016/s0006-3495(91)82041-0 · Cited by 902
Carotenoids as membrane stabilizers in chloroplasts
Havaux, M. (1998) · Trends in Plant Science · doi:10.1016/s1360-1385(98)01200-x · Cited by 683
Modulation of Liposomal Membrane Fluidity by Flavonoids and Isoflavonoids
Arora, A., Byrem, T. M., Nair, M. G., & Strasburg, G. M. (2000) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.1999.1525 · Cited by 594
Cuvelier, M., Richard, H., & Berset, C. (1996) · Journal of the American Oil Chemists' Society · doi:10.1007/bf02518121 · Cited by 588
Oxidative stress induced in pathologies: The role of antioxidants
Gaté, L., Paul, J., Ba, G. N., Tew, K. D., & Tapiero, H. (1999) · Biomedicine & Pharmacotherapy · doi:10.1016/s0753-3322(99)80086-9 · Cited by 387
Kaiser, R. D., & London, E. (1998) · Biochemistry · doi:10.1021/bi980064a · Cited by 375
del Baño, M. J., Lorente, J., Castillo, J., Benavente-García, O., del Río, J. A., Ortuño, A., Quirin, K.-W., & Gerard, D. (2003) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf0300745 · Cited by 368
LC/MS/MS Characterization of Phenolic Constituents in Dried Plums
Fang, N., Yu, S., & Prior, R. L. (2002) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf0201327 · Cited by 351
Almela, L., Sánchez-Muñoz, B., Fernández-López, J. A., Roca, M. J., & Rabe, V. (2006) · Journal of Chromatography A · doi:10.1016/j.chroma.2006.02.056 · Cited by 271
Caturla, N. (2003) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(02)01366-7 · Cited by 268
Antioxidant activity of lipid‐soluble phenolic diterpenes from rosemary
Richheimer, S. L., Bernart, M. W., King, G. A., Kent, M. C., & Beiley, D. T. (1996) · Journal of the American Oil Chemists' Society · doi:10.1007/bf02523927 · Cited by 261
Alves, D. S., Pérez-Fons, L., Estepa, A., & Micol, V. (2004) · Biochemical Pharmacology · doi:10.1016/j.bcp.2004.04.012 · Cited by 239
Self-citationThe Interaction of Flavonoids with Membranes: Potential Determinant of Flavonoid Antioxidant Effects
Erlejman, A. G., Verstraeten, S. V., Fraga, C. G., & Oteiza, P. I. (2004) · Free Radical Research · doi:10.1080/10715760400016105 · Cited by 236
Davenport, L., Dale, R. E., Bisby, R. H., & Cundall, R. B. (1985) · Biochemistry · doi:10.1021/bi00336a044 · Cited by 182
Señoráns, F. J., Ibáñez, E., Cavero, S., Tabera, J., & Reglero, G. (2000) · Journal of Chromatography A · doi:10.1016/s0021-9673(99)00941-3 · Cited by 157
Characteristics of self-quenching of the fluorescence of lipid-conjugated rhodamine in membranes.
MacDonald, R. I. (1990) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)77380-8 · Cited by 148
Flavonoids in Rosmarinus officinalis leaves
Okamura, N., Haraguchi, H., Hashimoto, K., & Yagi, A. (1994) · Phytochemistry · doi:10.1016/s0031-9422(00)90434-5 · Cited by 124
Effects of Green Tea Catechins on Membrane Fluidity
Tsuchiya, H. (1999) · Pharmacology · doi:10.1159/000028303 · Cited by 109
Urano, S., Yano, K., & Matsuo, M. (1988) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(88)90544-x · Cited by 106
Laporta, O., Pérez-Fons, L., Mallavia, R. M., Caturla, N., & Micol, V. (2006) · Food Chemistry · doi:10.1016/j.foodchem.2006.03.051 · Cited by 105
Self-citationdel Baño, M. J., Lorente, J., Castillo, J., et al. (2004) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf040078p · Cited by 102
del Baño, M. J., Castillo, J., Benavente-García, O., Lorente, J., Martín-Gil, R., Acevedo, C., & Alcaraz, M. (2006) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf0581574 · Cited by 85
Pérez-Fons, L., Aranda, F. J., Guillén, J., Villalaı́n, J., & Micol, V. (2006) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2006.07.004 · Cited by 76
Self-citationGarcía-García, J., Micol, V., de Godos, A. M., & Gómez-Fernández, J. C. (1999) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.1999.1507 · Cited by 75
Self-citationParasassi, T., Giusti, A. M., Gratton, E., Monaco, E., Raimondi, M., Ravagnan, G., & Sapora, O. (1994) · International Journal of Radiation Biology · doi:10.1080/09553009414550391 · Cited by 65
Caturla, N., Pérez-Fons, L., Estepa, A., et al. (2005) · Chemistry and Physics of Lipids · doi:10.1016/j.chemphyslip.2005.04.003 · Cited by 58
Self-citationThe formation of phenolic diterpenes in Rosmarinus officinalis L. under Mediterranean climate
Munné‐Bosch, S., Alegre, L., & Schwarz, K. (2000) · European Food Research and Technology · doi:10.1007/s002179900108 · Cited by 53
β-Carotene: interactions with α-tocopherol and ascorbic acid in microsomal lipid peroxidation
Zhang, P., & Omaye, S. T. (2001) · The Journal of Nutritional Biochemistry · doi:10.1016/s0955-2863(00)00143-1 · Cited by 51
Effects of (+)-totarol, a diterpenoid antibacterial agent, on phospholipid model membranes
Micol, V., Mateo, C. R., Shapiro, S., Aranda, F. J., & Villalaín, J. (2001) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/s0005-2736(01)00284-x · Cited by 46
Self-citationLiposoluble antioxidants provide an effective radioprotective barrier
Alcaraz, M., ACEVEDO, C., Castillo, J., Benavente-García, O., Armero, D., Vicente, V., & Canteras, M. (2009) · British Journal of Radiology · doi:10.1259/bjr/30930369 · Cited by 40
Cited by
Diniz do Nascimento, L., Moraes, A. A. B. D., Costa, K. S. D., Pereira Galúcio, J. M., Taube, P. S., Costa, C. M. L., Neves Cruz, J., de Aguiar Andrade, E. H., & Faria, L. J. G. D. (2020) · Biomolecules · doi:10.3390/biom10070988 · Cited by 470
Medicinal Plants of the Family Lamiaceae in Pain Therapy: A Review
Uritu, C. M., Mihai, C. T., Stanciu, G.-D., Dodi, G., Alexa-Stratulat, T., Luca, A., Leon-Constantin, M.-M., Stefanescu, R., Bild, V., Melnic, S., et al. (2018) · Pain Research and Management · doi:10.1155/2018/7801543 · Cited by 367
Rosmarinus officinalis L. (rosemary) as therapeutic and prophylactic agent
de Oliveira, J. R., Camargo, S. E. A., & de Oliveira, L. D. (2019) · Journal of Biomedical Science · doi:10.1186/s12929-019-0499-8 · Cited by 367
Rosmarinus officinalis L.: an update review of its phytochemistry and biological activity
Andrade, J. M., Faustino, C., Garcia, C., Ladeiras, D., Reis, C. P., & Rijo, P. (2018) · Future Science OA · doi:10.4155/fsoa-2017-0124 · Cited by 357
Mena, P., Cirlini, M., Tassotti, M., Herrlinger, K., Dall’Asta, C., & Del Rio, D. (2016) · Molecules · doi:10.3390/molecules21111576 · Cited by 288
Metadata
- Authors
- Pérez-Fons, L., GarzÓn, M. T., & Micol, V.
- Venue
- Journal of Agricultural and Food Chemistry
- Publisher
- American Chemical Society (ACS)
- Published
- 2009-11-19
- Volume
- 58
- Issue
- 1
- Pages
- 161-171
- ISSN
- 0021-8561 (ISSN-L)
- 1520-5118
- OpenAlex
- W1987370786
- Cited by
- 273
- References
- 37
- FWCI
- 6.17
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
