The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Development of an in Vitro Digestion Method To Assess Carotenoid Bioavailability from Meals
Abstract
The objective of this study was to develop a model for assessing the bioavailability of carotenoids from meals using an in vitro digestion procedure. A meal was prepared using baby food carrots, spinach, and a meat, plus tomato paste. The aqueous fraction was isolated from digesta to determine the quantity of carotenoids transferred from the food to micelles. The micellarization of lutein (25-40%) exceeded (p < 0.01) that of alpha- and beta-carotene (12-18%) and lycopene (<0.5%). Micellarization of carotenoids was not affected by elimination of the gastric phase of the digestive process. The absence of bile extract prevented the transfer of carotenoids from foods to micelles, whereas omission of pancreatin only reduced the micellarization of the carotenes. Differentiated cultures of Caco-2 human intestinal cells accumulated 28-46% of micellarized carotenoids from the medium after 6 h. These results support the usefulness of the in vitro digestion process as a rapid and cost-effective model for screening the bioavailability of carotenoids from meals.
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Charman, W. N., Porter, C. J. H., Mithani, S., & Dressman, J. B. (1997) · Journal of Pharmaceutical Sciences · doi:10.1021/js960085v · Cited by 617
Cited by
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Etcheverry, P., Grusak, M. A., & Fleige, L. E. (2012) · Frontiers in Physiology · doi:10.3389/fphys.2012.00317 · Cited by 391
Methods for determining bioavailability and bioaccessibility of bioactive compounds and nutrients
Santos, D. I., Saraiva, J. M. A., Vicente, A. A., & Moldão-Martins, M. (2019) · Innovative Thermal and Non-Thermal Processing, Bioaccessibility and Bioavailability of Nutrients and Bioactive Compounds · doi:10.1016/b978-0-12-814174-8.00002-0 · Cited by 153
Are lutein, lycopene, and β-carotene lost through the digestive process?
Kopec, R. E., Gleize, B., Borel, P., Desmarchelier, C., & Caris-Veyrat, C. (2017) · Food & Function · doi:10.1039/c7fo00021a · Cited by 72
Metadata
- Authors
- Garrett, D. A., Failla, M. L., & Sarama, R. J.
- Venue
- Journal of Agricultural and Food Chemistry
- Publisher
- American Chemical Society (ACS)
- Published
- 1999-09-16
- Volume
- 47
- Issue
- 10
- Pages
- 4301-4309
- ISSN
- 0021-8561 (ISSN-L)
- 1520-5118
- OpenAlex
- W2013476687
- Cited by
- 486
- References
- 1
- FWCI
- 2.14
- Type
- journal article
- Language
- en
- Open access
- closed
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Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
