The DOI matches its Crossref record; 42 of the 42 references it cites were found in a registry or an index.
Salen−Manganese Complexes as Catalytic Scavengers of Hydrogen Peroxide and Cytoprotective Agents: Structure−Activity Relationship Studies
Abstract
Synthetic catalytic scavengers of reactive oxygen species (ROS) may have broad clinical applicability. In previous papers, two salen-manganese complexes, EUK-8 and EUK-134, had superoxide dismutase (SOD) and catalase activities and prevented ROS-associated tissue injury. This study describes two series of salen-manganese complexes, comparing catalytic ROS scavenging properties and cytoprotective activities. The compounds vary widely in ability to scavenge hydrogen peroxide, with this activity most influenced by salen ring alkoxy substitution and aromatic bridge modifications. In contrast, all compounds show comparable SOD activities. The most active alkoxy-substituted catalase mimetics protected cultured cells from hydrogen peroxide, and a subset of these were also neuroprotective in a rodent stroke model. Thus, structural modification of the prototype EUK-8 yields compounds with enhanced catalase activity and, in turn, biological effectiveness. This supports the concept that salen-manganese complexes represent a class of SOD and, in particular, catalase mimetics potentially useful against ROS-associated diseases.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Free radicals in biology and medicine
(1991) · General Pharmacology: The Vascular System · doi:10.1016/0306-3623(91)90478-o · Cited by 17,178
Hydroperoxide metabolism in mammalian organs.
Chance, B., Sies, H., & Boveris, A. (1979) · Physiological Reviews · doi:10.1152/physrev.1979.59.3.527 · Cited by 5,827
Biochemistry of Oxidative Stress
Sies, H. (1986) · Angewandte Chemie International Edition in English · doi:10.1002/anie.198610581 · Cited by 1,306
Extension of Life-Span with Superoxide Dismutase/Catalase Mimetics
Melov, S., Ravenscroft, J., Malik, S., Gill, M. S., Walker, D. W., Clayton, P. E., Wallace, D. C., Malfroy, B., Doctrow, S. R., & Lithgow, G. J. (2000) · Science · doi:10.1126/science.289.5484.1567 · Cited by 912
Self-citationChilds, R. E., & Bardsley, W. G. (1975) · Biochemical Journal · doi:10.1042/bj1450093 · Cited by 893
Carboxyfullerenes as neuroprotective agents
Dugan, L. L., Turetsky, D. M., Du, C., Lobner, D., Wheeler, M., Almli, C. R., Shen, C. K.-F., Luh, T.-Y., Choi, D. W., & Lin, T.-S. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.17.9434 · Cited by 748
Oxidases and Related Redox Systems
Milazzo, G. (1975) · Bioelectrochemistry and Bioenergetics · doi:10.1016/0302-4598(75)80018-3 · Cited by 673
Biomimetic Oxidations Catalyzed by Transition Metal Complexes
Meunier, B. (2000) · IMPERIAL COLLEGE PRESS eBooks · doi:10.1142/p084 · Cited by 642
Superoxide and superoxide dismutases
Fridovich, I. (1993) · Free Radical Biology and Medicine · doi:10.1016/0891-5849(93)90188-z · Cited by 526
A novel neurological phenotype in mice lacking mitochondrial manganese superoxide dismutase
Melov, S., Schneider, J. A., Day, B. J., Hinerfeld, D., Coskun, P., Mirra, S. S., Crapo, J. D., & Wallace, D. C. (1998) · Nature Genetics · doi:10.1038/ng0298-159 · Cited by 489
Cited by
Crans, D. C., Smee, J. J., Gaidamauskas, E., & Yang, L. (2004) · Chemical Reviews · doi:10.1021/cr020607t · Cited by 1,364
Superoxide Dismutase Mimics: Chemistry, Pharmacology, and Therapeutic Potential
Batinić-Haberle, I., Rebouças, J. S., & Spasojević, I. (2010) · Antioxidants & Redox Signaling · doi:10.1089/ars.2009.2876 · Cited by 531
Redox-Directed Cancer Therapeutics: Molecular Mechanisms and Opportunities
Wondrak, G. T. (2009) · Antioxidants & Redox Signaling · doi:10.1089/ars.2009.2541 · Cited by 462
Catechol oxidase and phenoxazinone synthase: Biomimetic functional models and mechanistic studies
Dey, S. K., & Mukherjee, A. (2016) · Coordination Chemistry Reviews · doi:10.1016/j.ccr.2015.11.002 · Cited by 286
Cancer chemoprevention by the antioxidant tempol in Atm-deficient mice
Schubert, R. (2004) · Human Molecular Genetics · doi:10.1093/hmg/ddh189 · Cited by 139
Metadata
- Authors
- Doctrow, S. R., Huffman, K., Marcus, C. B., Tocco, G., Malfroy, E., Adinolfi, C. A., Kruk, H., Baker, K., Lazarowych, N., Mascarenhas, J., & Malfroy, B.
- Venue
- Journal of Medicinal Chemistry
- Publisher
- American Chemical Society (ACS)
- Published
- 2002-08-28
- Volume
- 45
- Issue
- 20
- Pages
- 4549-4558
- ISSN
- 0022-2623 (ISSN-L)
- 1520-4804
- OpenAlex
- W2048246398
- Cited by
- 274
- References
- 42
- FWCI
- 5.93
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Salen−Manganese Complexes as Catalytic Scavengers of Hydrogen Peroxide and Cytoprotective Agents: Structure−Activity Relationship Studies. https://app.cochat.ai/papers/10.1021/jm020207y
- The paper
- Doctrow, S. R., Huffman, K., Marcus, C. B., Tocco, G., Malfroy, E., Adinolfi, C. A., Kruk, H., Baker, K., Lazarowych, N., Mascarenhas, J., & Malfroy, B. (2002). Salen−Manganese Complexes as Catalytic Scavengers of Hydrogen Peroxide and Cytoprotective Agents: Structure−Activity Relationship Studies. Journal of Medicinal Chemistry. https://doi.org/10.1021/jm020207y
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
