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Cited by 531

The DOI matches its Crossref record; 313 of the 313 references it cites were found in a registry or an index.

Superoxide Dismutase Mimics: Chemistry, Pharmacology, and Therapeutic Potential

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Batinić-Haberle, Ines, Rebouças, Júlio S., Spasojević, Ivan·2010·Antioxidants & Redox Signaling
DOI 10.1089/ars.2009.2876
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Abstract

Oxidative stress has become widely viewed as an underlying condition in a number of diseases, such as ischemia–reperfusion disorders, central nervous system disorders, cardiovascular conditions, cancer, and diabetes. Thus, natural and synthetic antioxidants have been actively sought. Superoxide dismutase is a first line of defense against oxidative stress under physiological and pathological conditions. Therefore, the development of therapeutics aimed at mimicking superoxide dismutase was a natural maneuver. Metalloporphyrins, as well as Mn cyclic polyamines, Mn salen derivatives and nitroxides were all originally developed as SOD mimics. The same thermodynamic and electrostatic properties that make them potent SOD mimics may allow them to reduce other reactive species such as peroxynitrite, peroxynitrite-derived CO 3 ·− , peroxyl radical, and less efficiently H 2 O 2 . By doing so SOD mimics can decrease both primary and secondary oxidative events, the latter arising from the inhibition of cellular transcriptional activity. To better judge the therapeutic potential and the advantage of one over the other type of compound, comparative studies of different classes of drugs in the same cellular and/or animal models are needed. We here provide a comprehensive overview of the chemical properties and some in vivo effects observed with various classes of compounds with a special emphasis on porphyrin-based compounds. Antioxid. Redox Signal. 13, 877–918.

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Metadata

Authors
Batinić-Haberle, I., Rebouças, J. S., & Spasojević, I.
Venue
Antioxidants & Redox Signaling
Publisher
SAGE Publications
Published
2010-09
Volume
13
Issue
6
Pages
877-918
ISSN
  • 1523-0864 (ISSN-L)
  • 1557-7716
DOI
10.1089/ars.2009.2876
OpenAlex
W1987096917
Cited by
531
References
313
FWCI
27.37
Type
journal article
Language
en
Open access
green
Licence
journals.sagepub.com/page/policies/text-and-data-mining-license (tdm)

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CoChat. (2026). Citation check: Superoxide Dismutase Mimics: Chemistry, Pharmacology, and Therapeutic Potential. https://app.cochat.ai/papers/10.1089/ars.2009.2876
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Batinić-Haberle, I., Rebouças, J. S., & Spasojević, I. (2010). Superoxide Dismutase Mimics: Chemistry, Pharmacology, and Therapeutic Potential. Antioxidants & Redox Signaling. https://doi.org/10.1089/ars.2009.2876

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