The DOI matches its Crossref record; 12 of the 12 references it cites were found in a registry or an index.
Antiviral Activity of Glycyrrhizic Acid Derivatives against SARS−Coronavirus
Abstract
Glycyrrhizin (GL) was shown to inhibit SARS-coronavirus (SARS-CoV) replication in vitro. Here the anti-SARS-CoV activity of 15 GL derivatives was tested. The introduction of 2-acetamido-beta-d-glucopyranosylamine into the glycoside chain of GL resulted in 10-fold increased anti-SARS-CoV activity compared to GL. Amides of GL and conjugates of GL with two amino acid residues and a free 30-COOH function presented up to 70-fold increased activity against SARS-CoV but also increased cytotoxicity resulting in decreased selectivity index.
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Cites
Identification of a novel coronavirus in patients with severe acute respiratory syndrome
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Self-citationGlycyrrhizin, an active component of liquorice roots, and replication of SARS-associated coronavirus
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Small molecules targeting severe acute respiratory syndrome human coronavirus
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Chemical Modification of Glycyrrhizic Acid As A Route to New Bioactive Compounds for Medicine
Baltina, L. (2003) · Current Medicinal Chemistry · doi:10.2174/0929867033368538 · Cited by 244
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Identification of Glycyrrhizin as a Thrombin Inhibitor
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Cited by
Coronavirus disease 2019 (COVID-19): current status and future perspectives
Li, H., Liu, S.-M., Yu, X.-H., Tang, S.-L., & Tang, C.-K. (2020) · International Journal of Antimicrobial Agents · doi:10.1016/j.ijantimicag.2020.105951 · Cited by 1,156
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Antiviral effects of Glycyrrhiza species
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Drug Development and Medicinal Chemistry Efforts toward SARS‐Coronavirus and Covid‐19 Therapeutics
Ghosh, A. K., Brindisi, M., Shahabi, D., Chapman, M. E., & Mesecar, A. D. (2020) · ChemMedChem · doi:10.1002/cmdc.202000223 · Cited by 306
Metadata
- Authors
- Hoever, G., Baltina, L., Michaelis, M., Kondratenko, R., Baltina, L., Tolstikov, G. A., Doerr, H. W., & Cinatl, J.
- Venue
- Journal of Medicinal Chemistry
- Publisher
- American Chemical Society (ACS)
- Published
- 2005-01-19
- Volume
- 48
- Issue
- 4
- Pages
- 1256-1259
- ISSN
- 0022-2623 (ISSN-L)
- 1520-4804
- OpenAlex
- W2006718722
- Cited by
- 416
- References
- 12
- FWCI
- 4.86
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
